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Title Fundamentals of chromatin / Jerry L. Workman, Susan M. Abmayr, editors.
Imprint New York : Springer Science+Business Media, [2014]

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Subject Chromatin.
Chromatin -- physiology.
Alt Name Workman, Jerry L.
Abmayr, Susan M.
Description 1 online resource (594 pages) : illustrations
Bibliography Note Includes bibliographical references and index.
Contents Preface; Contents; Contributors; Chapter 1: Histone, Nucleosome, and Chromatin Structure; 1.1 Introduction to Chromatin Structure; 1.2 A History of Chromatin Structure; 1.3 The Nucleosome Core Particle Structure; 1.3.1 Overview of the High-Resolution Nucleosome Core Particle Structure; 1.3.2 Primary Structure of Histones; 1.3.3 Secondary Structure of Core Histones and the Architecture of the Histone Octamer; 1.3.4 Core Histone Tails and Extensions; 1.3.5 The DNA Superhelix and Core Histone-DNA Interactions; 1.3.6 The Nucleosome Core Particle Surface and Interactions.
1.3.7 Nucleosome Core Dynamics: PTMs, Variants, DNA Breathing, and Suboctameric Particles1.4 Linker Histone and the Chromatosome; 1.5 Higher-Order Chromatin Structure; 1.5.1 Secondary Structure of Chromatin; 1.6 Perspective; References; Chapter 2: Histone Chaperones in the Assembly and Disassembly of Chromatin; 2.1 Introduction; 2.1.1 A Working Model for Stepwise Nucleosome Assembly/Disassembly; 2.1.2 Overview of Histone Chaperones; 2.2 Histone Transport from the Cytoplasm to the Nucleus; 2.3 Replication-Dependent Chromatin Assembly; 2.3.1 Histone Eviction in Front of the Replication Fork.
2.3.2 Histone Deposition Behind the Replication Fork2.3.2.1 H3-H4 Deposition onto Newly Replicated DNA; H2A-H2B and H1 Deposition onto Newly Replicated DNA; Reassembly of Heterochromatin; 2.4 Reassembly of Centromeric Chromatin; 2.4.1 CenH3 Chaperones and Their Function; 2.5 Histone Chaperones in Replication-Independent Chromatin Disassembly and Assembly; 2.5.1 (H3-H4) 2 Tetramer Splitting; 2.5.2 Exchange of H2A.Z; 2.5.3 Exchange of H3.3; 2.5.4 Transcription-Dependent Chromatin Disassembly and Reassembly; Asf1; FACT; Spt6.
2.6 Histone Chaperones in Chromatin Assembly and Disassembly During DNA Repair2.7 Concluding Remarks; References; Chapter 3: Chromatin Remodeling Complexes; 3.1 Introduction; 3.1.1 Composition and Biophysical Properties of Nucleosomes; 3.1.2 Concepts of Nucleosome Phasing and Spacing; 3.2 Classification of Remodelers; 3.2.1 Chromatin Processes and Remodeler Functions; Chromatin Deposition and Assembly; Chromatin Editing; Chromatin Access; 3.2.2 Compositional Attributes Shared by Remodelers; 3.2.3 Remodeler Families and Compositional Specialization; ISWI Family. CHD Family3.2.3.3 INO80 Family; SWI/SNF Family; "Orphan" Remodelers; 3.2.4 PTM-Interacting Motifs and Combinatorial Regulation; Bromodomain; BAH Domain; CHD Domain; PHD Domain; 3.2.5 Remodeler Motif Utilization; 3.3 Remodeler Mechanisms and Regulation; 3.3.1 DNA Translocation Underlies Remodeler Mechanisms and Outcomes; 3.3.2 Mechanisms and Regulation of Chromatin Access; 3.3.3 Mechanisms and Regulation of Chromatin Assembly; 3.3.4 Mechanisms and Regulation of Chromatin Editing Involving H2A Variants.
Summary While there has been an increasing number of books on various aspects of epigenetics, there has been a gap over the years in books that provide a comprehensive understanding of the fundamentals of chromatin.?Chromatin is the combination of DNA and proteins that make up the genetic material of chromosomes. Its primary function is to package DNA to fit into the cell, to strengthen the DNA to prevent damage, to allow mitosis and meiosis, and to control the expression of genes and DNA replication. The audience for this book is mainly newly established scientists?and graduate studen.
Note Online resource; title from PDF (ebrary, viewed January 6, 2014).
ISBN 9781461486244 (electronic bk.)
1461486246 (electronic bk.)
ISBN/ISSN 10.1007/978-1-4614-8624-4
OCLC # 868922748
Additional Format Print version: Workman, Jerry L. Fundamentals of Chromatin. Dordrecht : Springer, 2013 9781461486237

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