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Title Prospects for chemoprevention of colorectal neoplasia : emerging role of anti-inflammatory drugs / Andrew T. Chan, Elmar Detering, editors.
Imprint Berlin ; New York : Springer, 2013.

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Series Recent results in cancer research, 0080-0015 ; v. 191
Recent results in cancer research ; v. 191.
Subject Colon (Anatomy) -- Cancer -- Chemoprevention.
Rectum -- Cancer -- Chemoprevention.
Anti-inflammatory agents.
Colonic Neoplasms.
Rectal Neoplasms.
Anti-Inflammatory Agents.
Alt Name Chan, Andrew T.
Detering, Elmar.
Description 1 online resource.
polychrome rdacc
Contents An Emerging Role for Anti-inflammatory Agents for Chemoprevention / Andrew T. Chan and Elmar Detering -- Mechanistic Aspects of COX-2 Expression in Colorectal Neoplasia / Dan A. Dixon, Fernando F. Blanco, Annalisa Bruno and Paola Patrignani -- Mode of Action of Aspirin as a Chemopreventive Agent / Melania Dovizio, Annalisa Bruno, Stefania Tacconelli and Paola Patrignani -- Coxibs: Pharmacology, Toxicity and Efficacy in Cancer Clinical Trials / Luis A. Garcia Rodriguez, Lucia Cea-Soriano, Stefania Tacconelli and Paola Patrignani -- COX-2 Active Agents in the Chemoprevention of Colorectal Cancer / Sarah Kraus, Inna Naumov and Nadir Arber -- New NSAID Targets and Derivatives for Colorectal Cancer Chemoprevention / Heather N. Tinsley, William E. Grizzle, Ashraf Abadi, Adam Keeton and Bing Zhu, et al. -- Aspirin in Prevention of Sporadic Colorectal Cancer: Current Clinical Evidence and Overall Balance of Risks and Benefits / Peter M. Rothwell -- Nutritional Agents with Anti-lnflammatory Properties in Chemoprevention of Colorectal Neoplasia / Mark A. Hull -- Genetics, Inheritance and Strategies for Prevention in Populations at High Risk of Colorectal Cancer (CRC) / John Burn, John Mathers and D. Tim Bishop.
Bibliography Note Includes bibliographical references.
Summary The prevention of colorectal cancer is a subject of increasing medical importance, and there have been a number of promising recent developments. This book examines in detail important aspects of the current status and future prospects for chemoprevention of colorectal tumors. Research into the mechanisms that lead from early colorectal adenoma to colorectal cancer is discussed. The role and modes of action of available drugs such as celecoxib and sulindac are described, and recent data from aspirin trials are analyzed. In addition, the possible impact of nutritional agents with anti-inflammat.
ISBN 9783642303319 (electronic bk.)
3642303315 (electronic bk.)
OCLC # 808484299

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