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Title Clinical trials of genetic therapy with antisense DNA and DNA vectors / edited by Eric Wickstrom.
Imprint New York, N.Y. : M. Dekker, [1998]
©1998

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LOCATION CALL # STATUS MESSAGE
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Subject Gene therapy -- Testing.
Antisense DNA -- Therapeutic use -- Testing.
Genetic vectors -- Therapeutic use -- Testing.
Clinical trials.
Genetic Therapy.
DNA, Antisense.
Genetic Vectors.
Clinical Trials as Topic.
Alt Name Wickstrom, Eric.
NetLibrary, Inc.
Description xvii, 427 pages : illustrations ; 24 cm
polychrome rdacc
Bibliography Note Includes bibliographical references and index.
Reproduction Electronic reproduction. Boulder, Colo. : NetLibrary, 2001. Available via World Wide Web. Access may be limited to NetLibrary affiliated libraries.
ISBN 0585344469 (electronic bk.) : $185.00
0824700856 (acid-free paper)
OCLC # 47011686
Additional Format Original (DLC) 98013317 (OCoLC)38439246.
Table of Contents
 Foreword: Genetic Therapy in the 21st Century / O. Michael Colvin 
 Preface: From Theory to Practice in Thirty Years / Eric Wickstrom 
 Contributors 
1A Brief History of Genetic Therapy: Gene Therapy, Antisense Technology, and Genomics / James W. Hawkins1
2Preclinical Development of Antisense Oligonucleotide Therapeutics for Cancer: Regulatory Aspects / Chang-Ho Ahn, Joseph J. DeGeorge39
3Commercial Scale Manufacturing of Oligonucleotides Under Good Manufacturing Practices / Jose E. Gonzalez, Richard G. Einig, Patricia Puma [et al.]53
4The Regulatory Process and Gene Therapy / Suzanne L. Epstein89
5Production of Clinical Lots of Gene Therapy Vectors Using Good Manufacturing Practice: Experience in a University Setting / Alan R. Davis, Colleen Baker101
6Gene Therapy Clinical Trials for Adenosine Deaminase Deficiency/Severe Combined Immunodeficiency / Erlinda M. Gordon, W. French Anderson111
7Development of an Oligodeoxynucleotide Pharmaceutical for the Treatment of Human Leukemia / Alan M. Gewirtz, Deborah Lee Sokol133
8Clinical Trials with Anti-p53 DNA, OL(1)p53, in Patients with Acute Myelogenous Leukemia and Myelodysplastic Syndrome / Patrick L. Iversen155
9Human Bcl-2 Antisense Therapy for Lymphomas / Finbarr E. Cotter, Andrew Webb, Paul Clarke [et al.]169
10Retroviral Gene Transfer in Autologous Bone Marrow and Stem Cell Transplantation / Rafat Abonour, Kenneth Cornetta191
11Adenoviral Gene Transfer of the Herpes Virus Thymidine Kinase Gene for Treating Gliomas / Jane B. Alavi, Jason G. Smith, Stephen L. Eck219
12Distribution and Toxicity of Retroviral Vectors After Intracavitary Delivery in Mouse and Man / Patrice S. Obermiller, Anne M. Pilaro, Carlos L. Arteaga [et al.]239
13Clinical and Immunologic Responses to Gene Transfer of an Allogeneic Major Histocompatibility Complex Antigen / Alison T. Stopeck, Evan M. Hersh257
14Defective Tumor Suppressor Gene Replacement and Oncogene Inactivation for the Treatment of Cancer / Jack Roth279
15The Molecular Basis of Bladder Cancer and Prospects for Gene Therapy Using Hammerhead Ribozymes / Eric J. Small, Mohammed Kashani-Sabet, David Y. Bouffard [et al.]295
16In Situ Gene Insertion for Immunotherapy Using Vaccinia Virus Vectors / Edmund C. Lattime, Laurence C. Eisenlohr, Michael J. Mastrangelo311
17Antisense Oligonucleotide-Based Therapy for HIV-1 Infection from Laboratory to Clinical Trials / Sudhir Agrawal331
18Treatment of Retinitis Induced by Cytomegalovirus Using Intravitreal Fomivirsen (Isis 2922) / Stanley T. Crooke353
19Synthetic DNA-Based Compounds for the Prevention of Coronary Restenosis: Current Status and Future Challenges / Andrew Zalewski, Yi Shi, John D. Mannion [et al.]363
20Prevention of Restenosis by Gene Targeting / Michael J. Mann, Heiko E. Von der Leyen, Victor J. Dzau395
 Index413


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