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LEADER 00000cam  2200601Ii 4500 
001    1036732041 
003    OCoLC 
005    20181130032000.8 
006    m     o  d         
007    cr |n||||||||| 
008    180520s2018    sz a    ob    001 0 eng d 
019    1037005970|a1040615303|a1042885234|a1047664134|a1048270466
020    9783319732695|q(electronic bk.) 
020    3319732692|q(electronic bk.) 
020    |z3319732684 
020    |z9783319732688 
024 7  10.1007/978-3-319-73269-5|2doi 
035    (OCoLC)1036732041|z(OCoLC)1037005970|z(OCoLC)1040615303
040    YDX|beng|epn|erda|cYDX|dN$T|dGW5XE|dEBLCP|dAZU|dUAB|dOCLCF
049    MAIN 
050  4 RC600 
072  7 MED|x044000|2bisacsh 
072  7 MJF|2bicssc 
072  7 HEA|x039000|2bisacsh 
072  7 MED|x038000|2bisacsh 
082 04 616.978|223 
245 00 Immune hematology :|bdiagnosis and management of 
       autoimmune cytopenias /|cJenny M. Despotovic, editor. 
264  1 Cham, Switzerland :|bSpringer,|c2018. 
300    1 online resource :|billustrations 
336    text|btxt|2rdacontent 
337    computer|bc|2rdamedia 
338    online resource|bcr|2rdacarrier 
347    text file|2rdaft|0
504    Includes bibliographical references and index. 
505 0  Intro; Preface; Contents; Contributors; Part I: Immune 
       Thrombocytopenia (ITP); Chapter 1: Background of Immune 
       Thrombocytopenia; Introduction; Historical Perspective; 
       Terminology; Presentation; Primary ITP and Secondary ITP; 
       Differential Diagnosis; Conclusion; References; Chapter 2:
       Pathophysiology of Immune Thrombocytopenia; Platelet 
       Autoantibodies; Balance of Platelet Destruction and 
       Production; Abnormal Megakaryocyte Morphology; Antibody 
       Destruction of Megakaryocytes; Inadequate Thrombopoietin 
       Levels; T Cell-Mediated ITP; T Cell-Propagated 
       Autoantibody Production; Helper T Cell Responses. 
505 8  Role of Th17 CellsRegulatory T cells; B Cell-Mediated ITP;
       B-Regulatory Cells; Myeloid-Derived Suppressor Cells; 
       Genetic Studies; Secondary ITP; Helicobacter pylori-
       Related ITP; CMV-Related ITP; Varicella Zoster-Related 
       ITP; Hepatitis C-Related ITP; HIV-Related ITP; Malignancy-
       Related ITP; Other Autoimmune Disorders; Evans Syndrome; 
       Autoimmune Lymphoproliferative Syndrome (ALPS); 
       References; Chapter 3: Presentation and Evaluation of 
       Immune Thrombocytopenia; Introduction; Clinical 
       Presentation; History; Physical Examination; Bleeding 
       Assessment; Initial Diagnostic Investigations. 
505 8  Diagnostic ApproachAdditional Testing for Suspected ITP; 
       The Role of Bone Marrow Testing; Platelet Antibody 
       Testing; Screening Tests for Associated Conditions; 
       Infectious Triggers for ITP: Hepatitis C, HIV, and H. 
       pylori; Autoimmune Conditions; Immunodeficiencies; 
       Summary; References; Chapter 4: The Treatment of Immune 
       Thrombocytopenia; Introduction; General Treatment 
       Considerations; Who Should Be Treated?; First-Line 
       Management; Corticosteroids; Mechanism of Action; Steroid 
       Treatment Recommendations; Intravenous Immunoglobulin; 
       Mechanism of Action; IVIG Treatment Recommendations. 
505 8  Anti-D ImmunoglobulinMechanism of Action; Anti-D Treatment
       Recommendations; Second-Line Therapy; Splenectomy; 
       Mechanism of Action; Splenectomy Treatment 
       Recommendations; Rituximab; Mechanism of Action; Rituximab
       Treatment Recommendations; Thrombopoietin Receptor 
       Agonists (TPO-RAs); Mechanism of Action; TPO-RA Adverse 
       Effects; Treatment Recommendations; Use of TPO-RAs in 
       Pediatric ITP; Use of TPO-RAs in Newly Diagnosed ITP; 
       Management of Life-Threatening Bleeding; Other Agents; 
       Antimetabolites; Novel Therapies; References; Part II: 
       Autoimmune Hemolytic Anemia (AIHA). 
505 8  Chapter 5: Background, Presentation and Pathophysiology of
       Autoimmune Hemolytic AnemiaHistory of Immune Hemolysis; 
       Definitions and Classification; Warm AIHA; 
       Pathophysiology; Clinical Features; Cold AIHA (Cold 
       Agglutinin Disease); Pathophysiology; Clinical Features; 
       Paroxysmal Cold Hemoglobinuria; Pathophysiology; Clinical 
       Features; Mixed AIHA; References; Chapter 6: Treatment of 
       Autoimmune Hemolytic Anemia; Introduction; Diagnosis and 
       Classification; Etiology; Frontline Treatment; Blood 
       Transfusions; Corticosteroids; Second-Line Treatments; 
       Rituximab; Splenectomy; Immunosuppressive Therapies. 
520    This text provides a concise yet comprehensive overview of
       the most common autoimmune cytopenias affecting adults and
       children. The book is divided into four sections, each of 
       which focuses on a major autoimmune cytopenia. The first 
       section features background, pathophysiology, presentation,
       evaluation, and treatment strategies for immune 
       thrombocytopenia (ITP), the most common cause of antibody-
       mediated platelet destruction. The second section reviews 
       common forms and treatment strategies for autoimmune 
       hemolytic anemia (AIHA), including a chapter dedicated 
       specifically to Evans Syndrome. The third section 
       comprehensively reviews the pathophysiology, diagnosis and
       current management approaches to thrombotic 
       thrombocytopenic purpura (TTP), a potentially life-
       threatening autoimmune syndrome. The book concludes with a
       final section on autoimmune neutropenia. Each section 
       includes a review of common underlying systemic autoimmune
       conditions and immune deficiency syndromes that can 
       accompany or cause autoimmune cytopenias. Written by 
       experts in each content area, Immune Hematology: Diagnosis
       and Management of Autoimmune Cytopenias is a valuable 
       resource for clinicians and professionals who treat 
       patients afflicted with autoimmune cytopenias, including 
       primary care providers, hematologist/oncologists, 
       immunologists, among others. 
588 0  Print version record. 
650  0 Autoimmune diseases|0
650  0 Immunology.|0
650  0 Hematology.|0
655  4 Electronic books. 
700 1  Despotovic, Jenny M.|0
776 08 |iPrint version:|z3319732684|z9783319732688
990    SpringerLink|bSpringer English/International eBooks 2018 -
       Full Set|c2018-10-31|yNew collection 
990    SpringerLink|bSpringer English/International eBooks 2018 -
       Full Set|c2018-11-30|yMaster record variable field(s) 
       change: 245, 505, 650|5OH1 
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