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Title Congenital heart diseases : the broken heart : clinical features, human genetics and molecular pathways / Silke Rickert-Sperling, Robert G. Kelly, David J. Driscoll, editors.
Imprint Wien : Springer, [2015]

View online
View online
Subject Congenital heart disease.
Heart Defects, Congenital.
Alt Name Rickert-Sperling, Silke,
Kelly, Robert G. (Biologist),
Driscoll, David J.,
Description 1 online resource (xxx, 765 pages) : illustrations (some color)
polychrome rdacc
Note Includes index.
Bibliography Note References6: Epicardium and Coronary Arteries; 6.1 Introduction; 6.2 The Embryonic Epicardium and Forming Coronary Vessels Constitute a Developmental Unit; 6.2.1 Tissue Interaction During Embryonic Development; 6.2.2 Formation of the Epicardial Epithelium from Pro-epicardial Progenitor Cells; 6.2.3 Epicardial EMT; 6.2.4 Epicardium-Myocardium Molecular Crosstalk; 6.3 Diversity of Coronary Cell Lineages; 6.3.1 Developmental Potential of Epicardial Cells; 6.3.2 Hierarchical Differentiation of Coronary Blood Vessel Cell Progenitors; Conclusion; References.
Contents Foreword; Preface; Contents; Contributors; Abbreviations; Part I: Introduction; 1: Cardiac Development and Animal Models of Congenital Heart Defects; 1.1 Introduction; 1.2 From the Cardiac Crescent to the Embryonic Heart Tube; 1.3 Ballooning Morphogenesis and Cardiac Septation; 1.4 Development of the Conduction System and Coronary Circulation; 1.5 Animal Models of Heart Development; References; 2: Normal Cardiac Anatomy and Clinical Evaluation; 2.1 Introduction Normal Heart Anatomy; 2.1.1 Venous Return to the Heart; 2.1.2 Atria; 2.1.3 Atrioventricular Valves; 2.1.4 Ventricles.
2.1.5 Semilunar Valves2.1.6 Great Arteries; 2.1.7 Coronary Arteries; 2.1.8 Electrical System; 2.2 Techniques, History, and Physical Examination; 2.2.1 The History; 2.2.2 Physical Examination; 2.2.3 The Electrocardiogram; 2.2.4 Chest X-Ray; 2.2.5 Echocardiography; 2.2.6 Cardiac Catheterization; Part II: Development of the Heart and Its Vessels; 3: First and Second Heart Field; 3.1 Introduction and Historical Perspective; 3.2 The First Heart Field; 3.3 The Second Heart Field; 3.3.1 Regulation of Proliferation and Differentiation; 3.3.2 Patterning the SHF.
3.4 Non-myocardial Derivatives of the First and Second Lineages3.4.1 Endocardium, Epicardium and Vascular Endothelial and Smooth Muscle Cells; 3.4.2 Skeletal Muscles of the Head and Neck; Conclusion; References; 4: Neural Crest; 4.1 Introduction; 4.2 Overview of CNCC Derivatives; 4.3 Signaling Pathways Regulating Early CNCC Migration; 4.4 CNCCs and Pharyngeal Arch Artery Remodeling; 4.5 CNCCs and Septation of the Cardiac Outflow Tract and Valvulogenesis; 4.6 Role of Interaction of CNCCs and the Secondary Heart Field; 4.7 CNCCs in Cardiac Innervation and Conduction.
4.8 Failure of Outflow Septation: Persistent Truncus Arteriosus4.9 Examples of Human Syndromes with Defective CNCC Development; 4.9.1 22q11.2 Deletion Syndromes; 4.9.2 CHARGE Syndrome; 4.9.3 LEOPARD and Noonan Syndromes; Conclusion; References; 5: Inflow Tract Development; 5.1 Introduction; 5.2 Structures Found at the Venous Pole; 5.3 Development of the Venous Pole; 5.3.1 The Dorsal Mesocardium; 5.3.2 The Atrioventricular Cushions; 5.3.3 The Primitive Pulmonary Vein; 5.3.4 The Sinus Venosus; 5.3.5 The Dorsal Mesenchymal Protrusion; 5.3.6 The Components of the Atrial Septum.
Summary This book provides comprehensive insights into congenital heart disease from embryonic development through to clinical features, including human genetics and our current knowledge of the underlying molecular pathways. It is divided into three parts: an introduction to the development of the heart and its vessels, an overview of the molecular pathways affecting the development of various cardiovascular structures, and a main section focusing on the different types of structural and nonstructural congenital heart diseases, including their clinical features, underlying genetic alterations and related animal models and pathways. Taken together these chapters, which were written by and for clinicians and researchers, provide an integrated and cutting-edge resource for all those who want to learn more about both the clinical aspects and the genetic and molecular basis of congenital heart disease.
Note Online resource; title from PDF title page (SpringerLink, viewed December 28, 2015).
ISBN 9783709118832 (electronic bk.)
3709118832 (electronic bk.)
ISBN/ISSN 10.1007/978-3-7091-1883-2
OCLC # 933509269
Additional Format Print version: Congenital heart diseases. 9783709118825 3709118824 (OCoLC)915491827

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