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Title Multiple sclerosis and CNS inflammatory disorders / edited by Lawrence M. Samkoff, Andrew D. Goodman.
Imprint Chichester, West Sussex, UK : John Wiley & Sons Inc., 2014.

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Series Neurology in practice
Neurology in practice.
Subject Multiple sclerosis.
Central nervous system -- Diseases -- Immunological aspects.
Multiple Sclerosis.
Central Nervous System Diseases -- immunology.
Neurogenic Inflammation -- physiopathology.
Alt Name Samkoff, Lawrence M., 1958-
Goodman, Andrew D., 1952-
Description 1 online resource.
Bibliography Note Includes bibliographical references and index.
Summary "Multiple Sclerosis and CNS Inflammatory Disorders is a practical guide to effective care of patients with multiple sclerosis and other neuroimmunologic disorders. It provides the scientific basis of multiple sclerosis, and its etiology, epidemiology and pathogenesis. It covers the diagnostic process, the course of the disease and prognosis, and the use of MRI in diagnosis and disease monitoring. Disease-modifying therapies, relapsing treatment algorithms, breakthrough RRMS, switching therapy, and progressive treatment algorithms are all discussed in detail. It also addresses multiple sclerosis in childhood and pregnancy, and includes assessment of 'alternative therapies'. This new addition to the Neurology in Practice series contains practical guidance and learning features: Algorithms and guidelines, 'Tips and Tricks' boxes on improving outcomes, 'Caution' warning boxes to avoiding problems, 'Science Revisited' - quick reminders of the basic science principles necessary for understanding. Multiple Sclerosis and CNS Neuroimmunologic Disorders is an ideal reference for neurologists in practice and training"--Provided by publisher.
Note Print version record and CIP data provided by publisher.
Contents ""Title page""; ""Copyright page""; ""Contributors""; ""Series Foreword""; ""Preface""; ""1 Etiology""; ""Background""; ""Genes""; ""Gender effects: Genetic or biologic?""; ""The role of the environment""; ""Combining risk factors""; ""Conclusion""; ""Acknowledgment""; ""References""; ""2 Immunopathogenesis of Multiple Sclerosis""; ""What does the neuropathology of MS tell us about its pathogenesis?""; ""Gray matter pathology""; ""Multiple sclerosis as an autoimmune disease""; ""Candidates for the self-antigen inA multiple sclerosis""; ""Antigen spreading""; ""Epitope spreading""
""Outside-in versus inside-out?""""Lymphocyte trafficking into the CNS""; ""Role of T cells in MS""; ""Role of B cells and humoral immunity""; ""Role of microglia and macrophages""; ""Role of other cells: Dendritic cells andA astrocytes""; ""Role of cytokines""; ""What might trigger autoimmunity?""; ""Further Reading""; ""3 Diagnostic Process""; ""Introduction""; ""Clinical features of MS""; ""Diagnostic evaluation of MS""; ""Conclusion""; ""Further Reading""; ""4 MRI in Diagnosis and Disease Monitoring""; ""Introduction""; ""MRI at presentation""; ""MRI diagnostic criteria""
""MRI consensus protocol""""MRI for monitoring disease andA treatment""; ""Limitations""; ""Nonconventional MRI""; ""Conclusions""; ""Acknowledgments""; ""References""; ""5 Relapsing MS: Disease Staging and Therapeutic Algorithms""; ""Introduction""; ""Window""; ""Prognostic factors""; ""Therapy""; ""Initiation""; ""Suboptimal response""; ""Combination therapy""; ""Rescue therapy""; ""Escalation""; ""Rapid advancement""; ""Conclusion""; ""Newer oral agents""; ""Further Reading""; ""6 Progressive MS Treatment Algorithms""; ""Background""; ""Challenges to clinical trials inA progressive MS""
""Clinical trials in progressive MS""""Monitoring progressive MS inA clinicalA practice""; ""Treatment of progressive MS inA clinicalA practice""; ""Stopping disease-modifying therapy""; ""Neuroprotective strategies""; ""Other treatment considerations""; ""Further Reading""; ""7 Sex-Determined Issues in Multiple Sclerosis""; ""Epidemiology of MS and gender""; ""Basic science of sex hormone and chromosome differences seen in MS""; ""Reproductive issues in MS""; ""Pregnancy and the MS patient""; ""Breastfeeding""; ""Female cancers""; ""Male sex hormones and concerns forA the male patient""
""Acknowledgments""""References""; ""8 Pediatric Multiple Sclerosis""; ""Introduction""; ""Definitions""; ""Clinical outcome following a first demyelinating attack""; ""Epidemiology and risk factors""; ""Clinical presentation""; ""Disease course""; ""Diagnostic considerations""; ""Differential diagnosis""; ""Treatment of acute demyelinating attacks""; ""Disease-modifying therapy""; ""Escalation of care for severe MS""; ""Symptomatic therapy""; ""Cognitive dysfunction and quality of life considerations""; ""Conclusions and future directions""; ""Further Reading""
ISBN 9781118298657 (ePub)
1118298659 (ePub)
9781118298664 (Adobe PDF)
1118298667 (Adobe PDF)
9780470673881 (pbk.)
Publisher # EB00587393 Recorded Books
OCLC # 871228581
Additional Format Print version: Multiple sclerosis and CNS inflammatory disorders. Chichester, West Sussex, UK : John Wiley & Sons Inc., 2014 9780470673881 (DLC) 2014007073

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