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Title Haploidentical transplantation : concepts & clinical application / Stefan O. Ciurea, Rupert Handgretinger, editors.
Imprint Cham, Switzerland : Springer, 2018.

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Series Advances and controversies in hematopoietic transplantation and cell therapy
Advances and controversies in hematopoietic transplantation and cell therapy.
Subject Hematopoietic stem cells -- Transplantation.
Alt Name Ciurea, Stefan O.,
Handgretinger, Rupert,
Description 1 online resource (xi, 337 pages) : illustrations (some color).
polychrome rdacc
Summary In this book, world-renowned experts in the field express well-reasoned opinions on a range of issues and controversies relating to haploidentical transplantation with the aim of providing practicing hematologists with clinically relevant and readily applicable information. Among the areas covered are graft manipulation and methods to control T-cell alloreactivity, the nature of the ideal graft and donor, haploidentical transplantation in pediatric and adult patients with malignant and nonmalignant diseases, immunologic reconstitution following transplantation, complications, and the prevention and treatment of relapse post transplantation. Attention is drawn to the implications of high-impact clinical trials whenever such trials are available. The readily intelligible text is complemented by numerous helpful tables, algorithms, and figures. The book will provide practical support for hematologists and transplant physicians as they attempt to provide optimal care in this exciting but increasingly complex medical specialty.
Contents Intro; Preface; Contents; 1: Historical Perspective and Current Trends in Haploidentical Transplantation; 1.1 Introduction; 1.2 T-Cell-Depleted HLA-Haploidentical Transplants: Biologic and Clinical Studies; 1.2.1 Strengths; 1.2.2 Drawbacks; 1.3 Today's World: State of the Art in T-Cell-Depleted HLA-Haploidentical Transplants; 1.4 T-Cell-Replete HLA-Haploidentical Transplants; 1.5 Expert Point of View; 1.5.1 The Way Forward for HLA-Haploidentical Transplant: T-Cell-Depleted or T-Cell-Replete?; References; Part I: Graft Manipulation and Methods to Control T-cell Alloreactivity.
Historical perspective and current trends in haploidentical transplantion -- Part 1: Graft manipulation and methods to control T-cell alloreactivity.-Positive CD34+ cell selection -- Selective allo-depletion: αβ and CD19+ cell T cell depletion -- T cell addback in T- cell depleted haploidentical transplant -- Hematopoietic myeloid growth factor primed bone marrow and peripheral blood hematopoietic progenitor cells -- Photodepletion of allo-reactive T cells -- Post-transplant cyclophosphamide in haploidentical transplant -- Part 2: Ideal graft & donor -- Graft source: Marrow versus peripheral blood with PTCy- Does it matter-- Anti-HLA antibodies: Assessment and mitigating strategies -- Selection of haploidentical donors: What is the art-- Myeloablative versus non-myeloablative conditioning regimen- Does it matter and how best to select-- Part 3: Disease-specific pediatric population -- Nonmalignant diseases in children.- en.-="" part="" 4:="" disease-specific="" adult="" population.-="" non-malignant="" adults.-="" acute="" myelogenous="" leukemia="" lymphomas-="" parameswaran="" hari.-="" chronic="" leukemias="" and="" myeloproliferative="" neoplasms.-="" immunologic="" reconstitution="" after="" haploidentical="" transplantation.-="" prevention="" treatment="" of="" relapse="" transplant.-="" unique="" complications="" limitations="" future="" prospects="" transplantation.
2: Toward Safer CD34+ Megadose T-Cell-Depleted Transplants Following Reduced Intensity and Nonmyeloablative Conditioning Regimens2.1 Introduction; 2.2 Overcoming HLA Barriers with T-Cell-Depleted Transplantation; 2.3 Megadose of CD34+ Cells: Regulatory Activity and Overcoming the HLA Barrier; 2.4 Megadose CD34+ Cells Coupled with TCD and Reduced Intensity Conditioning (RIC); 2.5 Combining HLA-Mismatched TCD Megadose BM with Adoptive Transfer of Veto Cells Under RIC; 2.6 Expert Point of View; 2.7 Future Directions.
4.3 Overcoming Leukemia Relapse with Next-Generation Immunotherapy4.3.1 Learning from Animal Models; 4.4 Adoptive Immunotherapy: Translating Lessons to the Clinical Setting in Haploidentical Transplants; 4.5 Expert Point of View; 4.6 Future Directions; References; 5: Haploidentical Transplantation Using Unmanipulated G-CSF-Primed Blood and Marrow as Allografts: Clinical Data and Challenges; 5.1 Introduction; 5.2 Effects of G-CSF on Hematopoietic Graft; 5.3 Establishment of the Beijing Protocol for Haploidentical Transplants.
Note Online resource; title from PDF title page (SpringerLink, viewed May 8, 2018).
ISBN 9783319543109 (electronic bk.)
3319543105 (electronic bk.)
9783319543093 (print)
ISBN/ISSN 10.1007/978-3-319-54310-9
OCLC # 1034985553
Additional Format Print version: Haploidentical transplantation. Cham, Switzerland : Springer, 2018 9783319543093 3319543091 (OCoLC)970684149

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