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LEADER 00000cam  2200553Mi 4500 
001    957655439 
003    OCoLC 
005    20181101045441.8 
006    m     o  d         
007    cr ||||||||||| 
008    160831s2016    sz      o     000 0 eng d 
019    957557883|a957617120|a957737565|a960448590|a962127263
020    9783319338897|q(electronic bk.) 
020    3319338897|q(electronic bk.) 
020    |z9783319338873 
020    |z3319338870 
035    (OCoLC)957655439|z(OCoLC)957557883|z(OCoLC)957617120
037    950840|bMIL 
040    IDEBK|beng|erda|epn|cIDEBK|dN$T|dYDX|dEBLCP|dN$T|dGW5XE
049    MAIN 
050  4 RM405.5 
060  4 QV 95 
072  7 MED|x071000|2bisacsh 
082 04 615.7/94 
245 00 NSAIDs and aspirin :|brecent advances and implications for
       clinical management /|cAngel Lanas, editor. 
264  1 [Switzerland] :|bSpringer,|c2016. 
300    1 online resource 
336    text|btxt|2rdacontent 
337    computer|bc|2rdamedia 
338    online resource|bcr|2rdacarrier 
347    text file|2rdaft|0
504    Includes bibliographical references and index. 
505 0  Preface; Acknowledgments; Contents; Contributors; 
       Abbreviations; Part I: Pharmacology and Mechanisms; 1: 
       Chemistry, Pharmacodynamics, and Pharmacokinetics of 
       NSAIDs; Introduction; Chemistry; Pharmacodynamics; 
       Nonselective vs. Isoform-Specific COX Inhibitors; 
       Structural Factors; Kinetic Factors; Allosteric Factors; 
       COX-Independent Actions; Pharmacokinetics; Absorption; 
       Distribution; Elimination; References; 2: Principles, 
       Mechanisms of Action, and Future Prospects of Anti-
       inflammatory Drugs; Introduction; Eicosanoids; COX 
       Pathway; COX-2; COX Inhibitors; Selective COX-2 Inhibitors
505 8  MPGES-1 InhibitorsAgonists and Antagonists of Prostanoid 
       Receptors; Cyclopentenone PGs; Other Approaches; Drugs 
       Acting on the 5-LOX Pathway; Dual COX-2/5-LO Inhibitors; 
       NSAIDs Releasing Nitric Oxide (NO) or Hydrogen Sulfide 
       (H2S); Aspirin-Triggered 15-Epi-lipoxins; Conclusions; 
       References; Part II: Clinical Effects and Drug Safety; 3: 
       Efficacy of NSAIDs in the Treatment of Rheumatic Diseases;
       Introduction; Osteoarthritis; Rheumatoid Arthritis; 
       Ankylosing Spondylitis; Acute Gout; Conclusion; 
505 8  4: Adverse Effects of NSAIDs in the Gastrointestinal Tract
       : Risk Factors of Gastrointestinal Toxicity with 
       NSAIDsIntroduction; Epidemiology; Pathogenesis; 
       Gastrointestinal Toxicity of NSAIDS; Upper 
       Gastrointestinal Tract; Lower Gastrointestinal Tract; 
       Other Gastrointestinal Symptoms; Risk Factors for 
       Gastrointestinal Toxicity; Concomitant Use of Aspirin and 
       Another NSAID; Concomitant Use with Anticoagulants; 
       Concomitant Use with Corticosteroids; Helicobacter pylori 
       Infection; Past History of Complicated Ulcers; 
       Stratification by Gastrointestinal Risks. 
505 8  Strategies to Reduce NSAID-Associated UlcersHistamine-2 
       Receptor Antagonist; Misoprostol; Proton-Pump Inhibitors; 
       COX-2 Inhibitors; Cardiovascular Risks of NSAIDS; 
       Balancing Cardiovascular and Gastrointestinal Risks; 
       Conclusions; References; 5: Adverse Effects of 
       Nonsteroidal Anti-inflammatory Drugs on the Cardiovascular
       System; The Need for NSAID Therapy in Patients with 
       Cardiovascular Disease; Cardiovascular Adverse Effects of 
       NSAIDs; Myocardial Infarction; Randomized Trials and Meta-
       analyses Focused on Cardiovascular Events; Meta-analyses; 
       Time Dependence of NSAID-Associated CV Risk. 
505 8  CV Risk of NSAID Use After First-Time Myocardial 
       InfarctionCV Risk of NSAIDs in Special Patient 
       Populations; Inflammatory Arthritides; Osteoarthritis; 
       Diabetes Mellitus; CV Adverse Effects of NSAIDs: Is There 
       a Genetic Predisposition?; CV Adverse Effects of NSAIDs: 
       Is COX-2-Mediated Immunomodulation Responsible?; Stroke; 
       Non-ischemic CV Adverse Effects of NSAIDs; Congestive 
       Heart Failure; Atrial Fibrillation; Effects on Renal 
       Function and Blood Pressure; NSAID-Induced Fluid and 
       Electrolyte Disturbances; Peripheral Edema. 
520    This volume is a state-of-the art resource on the recent 
       advances and clinical management of NSAIDs and aspirin. 
       The text provides a thorough overview of NSAIDS and 
       aspirin, reviewing such topics as pharmacology and 
       mechanisms, clinical effects, and the safety and efficacy 
       of these drugs. It also focuses on the effect of the drugs
       on the cardiovascular system and in the prevention of GI 
       cancer. Practical recommendations for a safe prescription 
       of NSAIDs are also included. Written by experts in the 
       field, NSAIDs and Aspirin: Recent Advances and 
       Implications for Clinical Management is a comprehensive 
       text of great value to gastroenterologists, 
       rheumatologists, cardiologists, oncologists, orthopedists,
       trauma and internal medicine specialists. 
650  0 Nonsteroidal anti-inflammatory agents.|0
650  0 Aspirin.|0
650  2 Anti-Inflammatory Agents, Non-Steroidal.|0https:// 
655  4 Electronic books. 
700 1  Lanas, A.|q(Ángel)|0
776 08 |iPrint version:|tNSAIDs and aspirin.|z9783319338873
990    SpringerLink|bSpringer English/International eBooks 2016 -
       Full Set|c2018-10-31|yNew collection 
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