| Series |
Oxidative Stress in Applied Basic Research and Clinical Practice, 2197-7224 |
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Oxidative stress in applied basic research and clinical practice.
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| Subject |
Cornea.
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Cornea -- Diseases.
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Crystalline lens.
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Eye -- Diseases.
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| Alt Name |
Babizhayev, Mark A.,
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Li, David Wan-Cheng,
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Kasus-Jacobi, Anne,
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Žorić, Lepša,
|
|
Alió, Jorge L.,
|
| Description |
1 online resource (xvi, 447 pages) : illustrations (some color). |
|
polychrome rdacc |
| Note |
Includes index. |
| Contents |
Contributors; About the Editors; Part I: Basic Science in Cornea; Chapter 1: Oxidative Stress in Cornea; 1.1 Oxidative Stress; 1.2 Oxidative Stress in Cornea; 1.2.1 Antioxidant Defenses of the Tears, Aqueous Humor, and Cornea; 1.2.2 Oxidative Stress as a Toxin; 1.2.2.1 Oxidative Damage; 1.2.2.2 Cell Arrest; 1.2.3 Oxidative Stress as Signal Molecules; 1.2.3.1 Inflammation; 1.2.3.2 Proliferation; 1.2.3.3 Differentiation; 1.2.4 Other Corneal Diseases; References; Chapter 2: Corneal Degenerations; 2.1 Introduction; 2.2 Age-Related Corneal Degenerations; 2.2.1 Arcus Senilis. |
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3.7.3.1 Systemic Factors3.7.3.2 Thyroxine as a Regulatory Factor; 3.7.4 Iron-Mediated Translational Regulation of Ferritin and Ferritoid; 3.7.5 The Ferritin-Ferritoid Interactions Required for Nuclear Transport, Involve the Phosphorylation of Ferritoid; 3.7.6 Does the CE of the Adult Cornea Have Ferritin-Ferritoid Complexes, and Why Are They in the Embryo; References; Chapter 4: Excitatory Amino Acid Transporters, Xc- Antiporter, γ-Glutamyl Transpeptidase, Glutamine Synthetase, and Glutathione in Human Corneal Epithelial Cells; 4.1 Introduction; 4.2 Materials and Methods; 4.3 Results. |
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2.2.2 Vogt Limbal Girdle2.2.3 Crocodile Shagreen; 2.2.4 Peripheral Corneal Guttae; 2.3 Corneal Degenerations with Tissue Thinning; 2.3.1 Terrien's Marginal Degeneration; 2.3.2 Dellen; 2.4 Corneal Degenerations with Material Deposits; 2.4.1 Salzmann's Nodular Degeneration; 2.4.2 Band Keratopathy; 2.4.3 Lipid Keratopathy; 2.4.4 Spheroidal Keratopathy; 2.4.5 Vortex Keratopathy; 2.4.6 Pigment Deposition Keratopathies; 2.4.6.1 Pterygium; 2.4.6.2 Keratoconus; 2.4.6.3 Refractive Surgery; 2.5 Conclusions; References. |
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Chapter 3: Corneal Epithelial Nuclear Ferritin and Its Transporter Ferritoid Afford Unique Protection to DNA from UV Light and Reactive Oxygen Species3.1 Introduction; 3.2 Free Iron and UV-Induced Damage to DNA; 3.3 Cytoplasmic Ferritin; 3.4 The Nuclear Ferritin of Corneal Epithelial Cells; 3.5 The Role of Nuclear Ferritin in Protecting CE Cell DNA from Damage by UV Radiation; 3.5.1 Protection from Damage by Reactive Oxygen Species (ROS); 3.6 Ferritoid: The Nuclear Transporter for CE Cell Ferritin; 3.6.1 Isolation of a cDNA for Ferritoid and its Tissue Specificity. |
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3.6.2 Functional Analysis of the Nuclear Transport of Ferritin by Ferritoid3.6.3 CE Nuclear Ferritin: A Stable Heteropolymeric Ferritin-Ferritoid Complex with Unique Properties; 3.6.4 Size(s) of the Ferritin-Ferritoid Complex(es); 3.6.5 Similarities of the CE Nuclear Ferritin-Ferritoid Complexes to the Bacterial DNA-Binding Proteins of Starvation (Dps); 3.7 Developmental Analyses of Ferritin and Ferritoid; 3.7.1 Ferritin and Ferritoid mRNAs During Development; 3.7.2 Ferritin and Ferritoid Proteins During Development; 3.7.3 Developmental Regulation of Ferritin and Ferritoid. |
| Summary |
This comprehensive volume presents data describing the role of oxidative stress in anterior eye disease. The content is divided into three logical parts: basic science of the cornea, basic science of the lens, and clinical practices. The first two parts include eighteen chapters that discuss topics ranging from oxidative stress and dry eye disease, endogenous protection of corneal cells against oxidative damage, the therapeutic potential of corneal stem cells, etiology of cataracts and preventive measures, corneal degeneration through oxidative stress and cataract formation, and function and. |
| Note |
Online resource; title from PDF title page (SpringerLink, viewed January 5, 2015). |
| ISBN |
9781493919352 (electronic bk.) |
|
1493919350 (electronic bk.) |
|
1493919342 |
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9781493919345 |
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9781493919345 |
| ISBN/ISSN |
10.1007/978-1-4939-1935-2 |
| OCLC # |
898125742 |
| Additional Format |
Print version: Babizhayev, Mark A. Studies on the Cornea and Lens. New York, NY : Springer New York, 2014 9781493919345 |
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