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Title New therapeutic agents in thrombosis and thrombolysis / edited by Arthur A. Sasahara, Joseph Loscalzo.
Imprint New York : M. Dekker, [1997]
©1997

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Subject Thrombolytic therapy.
Fibrinolytic agents.
Thrombosis.
Thrombolytic Therapy.
Thrombosis -- drug therapy.
Fibrinolytic Agents.
Hemostasis -- drug effects.
Alt Name Sasahara, Arthur A. (Arthur Asao), 1927-
Loscalzo, Joseph.
NetLibrary, Inc.
Description xiv, 681 pages : illustrations ; 26 cm
Bibliography Note Includes bibliographical references and index.
Reproduction Electronic reproduction. Boulder, Colo. : NetLibrary, 2001. Available via World Wide Web. Access may be limited to NetLibrary affiliated libraries.
ISBN 0585347735 (electronic bk.) : $195.00
082479866X (hardcover : alk. paper)
OCLC # 47011204
Additional Format Original (DLC) 97012542 (OCoLC)36682384.
Table of Contents
 Preface 
 Contributors 
1Overview of Hemostasis and Fibrinolysis / Joseph Loscalzo, Andrew I. Schafer1
2A Survey of Animal Modes to Develop New and Novel Antithrombotic Agents / Walter Jeske, Demetra D. Callas, Brigitte Kaiser [et al.]9
3Experimental Strategies for Assessing Antithrombotic Benefits and Hemorrhagic Risks of Novel Antithrombotic Agents / Laurence A. Harker, Stephen R. Hanson29
4Design Issues in Clinical Trials of Thrombolytic and Antithrombotic Agents / Dina S. Stolman, Jay P. Siegel, Marc K. Walton [et al.]49
5Overview of New Developments in Heparins, Thrombin Inhibitors, and Other New and Novel Agents / Jeffrey I. Weitz, Jack Hirsh77
6Low-Molecular-Weight Heparins: Biochemistry and Pharmacology / Meyer Michel Samama, Pierre Claude Desnoyers87
7Low-Molecular-Weight Heparins: Prophylaxis of Venous Thrombosis / Vijay Vir Kakkar103
8Low-Molecular-Weight Heparins: Treatment of Venous Thromboembolism / Philomeen M. M. Kuijer, Martin H. Prins, Harry Roger Buller129
9Direct Thrombin Inhibitors: Active-Site Inhibitors of Thrombin / Jules A. Shafer143
10Direct Thrombin Inhibitors in Venous Thromboembolism / Mark A. Crowther, Jeffrey S. Ginsberg159
11Direct Thrombin Inhibitors in Arterial Thrombosis / Bernard Rudolph Erickson, Eric Jeffrey Topol169
12Direct Thrombin Inhibitors: Hirulog / John M. Maraganore191
13Modulation of the Protein C Pathway as a Therapy for Thrombosis / Charles T. Esmon209
14Tissue Factor Pathway Inhibitor / Thomas J. Girard225
15Direct Factor Xa Inhibitors / George P. Vlasuk261
16Overview of Inhibition of Platelet Functions / James T. Willerson, Claude R. Benedict285
17Pharmacology and Clinical Development of Abciximab (c7E3 Fab, ReoPro): A Monoclonal Antibody Inhibitor of GPIIb/IIIa and [actual symbol not reproducible] / Robert E. Jordan, Mary Ann Mascelli, Marian T. Nakada [et al.]291
18Clinical Use of a Monoclonal Antibody to the Platelet Glycoprotein IIb/IIIa Receptor / James J. Ferguson, James T. Willerson315
19Integrilin: Synthetic Peptides Against the Platelet Glycoprotein IIb/IIIa Receptor / Barbara E. Tardiff, Julie M. Miller, Robert A. Harrington [et al.]333
20Tirofiban, a Nonpeptide Inhibitor of the Platelet Glycoprotein IIb/IIIA Receptor / Lawrence I. Deckelbaum, Frederic L. Sax, William Grossman355
21Aurin Tricarboxylic Acid: Inhibitor of von Willebrand Factor Attachment to Platelet GPIb / Martin D. Phillips, Joel L. Moake367
22Antagonism of Platelet Glycoprotein Ib Receptors: Protective Effects in Injured Coronary Arteries / James T. Willerson385
23Oxygen-Derived Free Radicals and Arterial Thrombosis / Paolo Golino407
24Platelet Procoagulant Activity / Permual Thiagarajan, Claude R. Benedict419
25Development of Unstable Angina and Myocardial Infarction: Importance of Platelets, Platelet- and Endothelium-Derived Mediators, and Monocytes/Macrophages in Thrombosis, Vasoconstriction, and Neointimal Proliferation / James T. Willerson435
26Introduction to the Section on New Thrombolytic Agents / Marc Verstraete449
27Animal Models to Assess the Safety and Efficacy of Thrombolytic Agents / Jean Marie Stassen451
28Biochemistry, Pharmacology, and Initial Clinical Experience with TNK-tPa / E. R. McCluskey, Bruce A. Keyt, Canio J. Refino [et al.]475
29Clinical and Preclinical Profile of the Novel Recombinant Plasminogen Activator Reteplase / Ulrich Martin495
30Recombinant Urokinase (r-UK): Biochemistry, Pharmacology, and Clinical Experience / R. Bruce Credo, Sandra E. Burke, Walter M. Barker [et al.]513
31Pro-urokinase: History, Mechanisms of Action, and Clinical Development / Victor Gurewich539
32Recombinant Glycosylated Pro-urkinase: Biochemistry, Pharmacology, and Early Clinical Experience / R. Bruce Credo, Sandra E. Burke, Walter M. Barker [et al.]561
33Recombinant Staphylokinase for Thrombolytic Therapy / Steven Vanderschueren, Frans Van de Werf, Desire Collen591
34Desmodus rotundus (Vampire Bat) Plasminogen Activator [actual symbol not reproducible]: A Superior Thrombolytic Created by Evolution / Wolf-Dieter Schleuning, Akhileshwar Bhargava, Peter Donner603
35Antibody Targeting: A Strategy for Improving Thrombolytic Therapy / Edgar Haber625
36Thrombolytic Agents in Development / Marc Verstraete, Fedor Bachmann639
 Index649