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Title The essential guide to N-of-1 trials in health / Jane Nikles, Geoffrey Mitchell, editors.
Imprint Dordrecht : Springer, [2015]

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Subject Drugs -- Testing.
Crossover trials.
Alt Name Nikles, Jane,
Mitchell, Geoffrey,
Description 1 online resource (xi, 245 pages)
polychrome rdacc
Bibliography Note Includes bibliographical references and index.
Contents Preface -- Introduction -- What are N-of-1 trials?- N-of-1 trials in the behavioural sciences -- N-of-1 trials in medical contexts -- Aggregated N-of-1 trials -- Methodological considerations for N-of-1 trials -- Randomization, allocation concealment and blinding -- Data collection and quality control -- Individual reporting of N-of-1 trials to patients and clinicians -- Assessing and reporting adverse events -- Research ethics and N-of-1 trials -- Statistical analysis of N-of-1 trials -- The economics of N-of-1 trials -- Reporting N-of-1 trials to professional audiences -- Single patient open trials -- Systematic review and meta-analysis using N-of-1 trials -- Where are N-of-1 trials headed?- Index.
Summary N-of-1 trials, a type of individualized randomized controlled trial, are relevant to almost every discipline in medicine and psychology. They can tell the clinician with precision whether a treatment works in that individual, which distinguishes from the information available from most other trial designs. They have the potential to revolutionize the way clinical medicine is practiced. Whether you are a busy clinician, a researcher or a student, this book provides everything you need to know about N-of-1 trials. Written and edited by some of the world's leading experts on N-of-1 trials, the book presents state of the art knowledge about N-of-1 trials, with chapters on ethics, statistics, health economics, design, analysis and reporting, and more. Full of examples and well illustrated, it is a comprehensive compendium of issues surrounding the design, conduct, interpretation and implementation of N-of-1 trials in a health system.
Access License restrictions may limit access.
Note Vendor-supplied metadata.
ISBN 9789401772006 electronic bk.
9401772002 electronic bk.
9401771995 (print)
9789401771993 (print)
ISBN/ISSN 10.1007/978-94-017-7200-6
OCLC # 922965845
Additional Format Printed edition: 9789401771993

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