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Title Diabetes mellitus : a risk factor for Alzheimer's disease / Yusaku Nakabeppu, Toshiharu Ninomiya, editors.
Imprint Singapore : Springer, [2019]

View online
View online
Series Advances in experimental medicine and biology ; 1128.
Advances in experimental medicine and biology ; v. 1128.
Subject Diabetes.
Alzheimer's disease -- Risk factors.
Diabetes Mellitus.
Alt Name Nakabeppu, Yusaku,
Ninomiya, Toshiharu,
Description 1 online resource.
Bibliography Note Includes bibliographical references.
Contents Intro; Contents; Chapter 1: Origins of Brain Insulin and Its Function; 1.1 Introduction; 1.2 Roles of Insulin in Brain; 1.3 Structure and Expression of the Insulin Genes; 1.4 Origins of Brain Insulin; 1.5 Conclusions; References; Chapter 2: Epidemiological Evidence of the Relationship Between Diabetes and Dementia; 2.1 Introduction; 2.2 Epidemiological Evidence of an Increased Risk of Dementia in Patients with Diabetes Mellitus; 2.3 Morphological Changes of the Brain in Elderly Subjects with Diabetes Mellitus
2.4 Possible Biological Mechanisms Underlying the Association Between Diabetes Mellitus and Dementia2.4.1 Cardiovascular Risk Factors; 2.4.2 Glucose Toxicity and Oxidative Stress; 2.4.3 Hyperinsulinemia; 2.4.4 Inflammation; 2.4.5 Hypoglycemic Episode; 2.5 Conclusions; References; Chapter 3: Molecular Pathophysiology of Insulin Depletion, Mitochondrial Dysfunction, and Oxidative Stress in Alzheimer's Disease Brain; 3.1 Introduction; 3.2 Altered Expression of Diabetes-Related Genesin Alzheimer's Disease Brains
3.3 Insulin Depletion, Impaired Insulin Signaling, and Mitochondrial Dysfunction in AD Brain3.4 Increased Accumulation of Oxidized DNA Lesionsand Altered Defense System in AD Brain; 3.5 8-Oxoguanine Accumulated in DNA May Be Involvedin AD Pathology; 3.6 Conclusions; References; Chapter 4: The Full Spectrum of Alzheimer's Disease Is Rooted in Metabolic Derangements That Drive Type 3 Diabetes; 4.1 Alzheimer's Disease Fundamentals; 4.1.1 Alzheimer's Disease: Definition and Diagnostics Overview; 4.1.2 Aging Versus Alzheimer's Disease; 4.1.3 Characteristic Neuropathology Neuroinflammation4.2.7.6 Role of Ischemic Injury; Oligodendrocyte Dysfunction; Current Limitations in Our Assessments of White Matter Degeneration in AD; 4.2.8 Microvascular Degeneration; Role of Vascular Degeneration in Dementia; Nature of Microvascular Disease in AD; Consequences of Brain Microvascular Disease; 4.2.9 Blood-Brain Barrier Disruption in AD; 4.3 What Comes First?; 4.4 Brain Metabolic Dysfunction in AD; 4.4.1 Impairments in Brain Glucose Utilization; 4.4.2 Insulin and Insulin-Like Growth Factor (IGF) Functions in the Brain
Note 4.4.3 Lessons from Experimental Models of Brain Insulin Deficiency and Resistance
Summary This book describes the precise mechanisms by which insulin resistance and diabetes mellitus (DM) act as risk factors for Alzheimer's disease (AD). It opens by discussing the de novo synthesis of insulin in the brain and its functional significance with regard to glucose metabolism and maintenance of neuronal function in the brain. The epidemiological evidence that DM is a risk factor for the development of dementia, including AD as well as vascular dementia, is then examined. Subsequent chapters explore in depth the mechanisms involved in this relationship, including abnormal protein processing, dysregulated glucose metabolism, impaired insulin signaling, and mitochondrial dysfunction. The molecular interactions between diabetes and AD are fully discussed, highlighting the pathological molecular mechanisms induced by diabetes that promote and accelerate AD pathology. Finally, diagnostic biomarkers and potential therapeutic approaches for AD are considered on the basis of the presented evidence. In providing answers to the critical questions of whether and why DM is a risk factor for AD, this book will hold appeal for a wide interdisciplinary audience.
Note Online resource; title from digital title page (viewed on June 26, 2019).
ISBN 9789811335402 (electronic book)
9811335400 (electronic book)
ISBN/ISSN 10.1007/978-981-13-3540-2
OCLC # 1101031932
Additional Format Print version: Nakabeppu, Yusaku. Diabetes Mellitus : A Risk Factor for Alzheimer's Disease. Singapore : Springer, 2019 9789811335396.

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