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Title Freeze-drying/lyophilization of pharmaceutical and biological products / edited by Louis Rey, Joan C. May.
Imprint New York : Marcel Dekker, [1999]

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Series Drugs and the pharmaceutical sciences ; 96.
Drugs and the pharmaceutical sciences ; v. 96.
Subject Freeze-drying.
Drugs -- Drying.
Biological products -- Drying.
Freeze Drying -- methods.
Biological Factors.
Pharmaceutical Preparations.
Alt Name Rey, Louis.
May, Joan C. (Joan Christine)
NetLibrary, Inc.
Description ix, 477 pages : illustrations ; 24 cm.
Bibliography Note Includes bibliographical references and index.
Reproduction Electronic reproduction. Boulder, Colo. : NetLibrary, 2000. Available via World Wide Web. Access may be limited to NetLibrary affiliated libraries.
ISBN 0585133387 (electronic bk.) : $195.00
0824719832 (acid-free paper)
OCLC # 45729293
Additional Format Original (DLC) 99026168 (OCoLC)41096228.
Table of Contents
1Glimpses into the Realm of Freeze-Drying: Classical Issues and New Ventures / Louis Rey1
2Potential Energy Surfaces, Computer Simulations, and the Structure of Water / Robert O. Watts31
3Structural and Dynamic Properties of Bulk and Confined Water / Marie-Claire Bellissent-Funel, Jose Teixeira53
4Experimental Freeze-Drying: Procedures and Equipment / Hanna Willemer79
5Freezing- and Drying-Induced Perturbations of Protein Structure and Mechanisms of Protein Protection by Stabilizing Additives / John F. Carpenter, Ken-ichi Izutsu, Theodore W. Randolph123
6Mechanisms of Protein Stabilization During Freeze-Drying and Storage: The Relative Importance of Thermodynamic Stabilization and Glassy State Relaxation Dynamics / Michael J. Pikal161
7Regulatory Control of Freeze-Dried Products: Importance and Evaluation of Residual Moisture / Joan C. May199
8Basic Aspects and Industrial Strategies for the Preservation of Microorganisms by Freezing and Drying / Hiroshi Souzu231
9Industrial Freeze-Drying for Pharmaceutical Applications / Georg-Wilhelm Oetjen267
10Industrial Freeze-Drying of Vaccines Destined for Veterinary Purposes: An Overview [et al.] / Pierre Precausta, Noel Genin, Gerard Benet337
11Manufacturing Principles of Freeze-Dried Collagen Sponges: Characteristics and Applications / Petra Tewes-Schwarzer359
12Lyophilization Process Validation / Christian Bindschaedler373
13Critical Steps in the Preparation of Elastomeric Closures for Biopharmaceutical Freeze-Dried Products / Maninder S. Hora, Sidney N. Wolfe409
14Technical Procedures for Operation of Cleaning-in-Place and Sterilization-in-Place Process for Production Freeze-Drying Equipment / Gilles A. Beurel423
15Studies on Development of Manufacturing Processes for Pharmaceutical Freeze-Dried Products / Yusuke Suzuki, Yutaka Sumi, Taiichi Mizuta433
16Potential Prospects in Freeze-Drying / Louis Rey465