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Title Aldehyde dehydrogenases : from alcohol metabolism to human health and precision medicine / Jun Ren, Yingmei Zhang, Junbo Ge, editors.
Imprint Singapore : Springer, [2019]

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Series Advances in experimental medicine and biology, 2014-8019 ; volume 1193
Advances in experimental medicine and biology ; v. 1193. 0065-2598
Subject Aldehyde dehydrogenase.
Aldehyde Dehydrogenase -- metabolism.
Aldehyde Dehydrogenase -- therapeutic use.
Cardiovascular Diseases -- therapy.
Alt Name Ren, Jun, Ph. D.,
Zhang, Yingmei,
Ge, Junbo,
Description 1 online resource (xx, 253 pages) : illustrations (some color).
Bibliography Note Includes bibliographical references.
Contents Role of alcohol oxidative metabolism in its cardiovascular and autonomic effects -- Environmental aldehyde sources and the health implications of exposure -- ALDHand cardiovascular disease -- Aldehyde dehydrogenases: From alcohol metabolism to human health and precision medicine -- Aldehyde dehydrogenase and heart Failure -- Mitochondrial aldehyde dehydrogenase in myocardial ischemic and ischemia-reperfusion injury -- East Asian variant aldehyde dehydrogenase genotype (ALDH2*2*) contributes to coronary artery spasm and acute myocardial infarction -- Aldehyde dehydrogenases genetic polymorphism and obesity: from genomics to behavior and health -- Aldehyde dehydrogenase (ALDH) in diabetic heart diseases -- The role of ALDHin sepsis and the to-be-discovered mechanisms -- ALDHand stroke -- ALDHand hypertension -- ALDHand cancer therapy -- ALDHpolymorphism and ethanol consumption: A genetic-environmental interaction in carcinogenesis -- ALDHand aging.
Summary "This volume covers the science of ALDH enzymes in relation to chronic disease processes and the future therapeutic potentials of targeting ALDH in these processes. It thoroughly reviews the roles of ALDH family in alcohol metabolism, as well as recent findings of their emerging roles in a variety of human pathologies such as cardiovascular diseases, diabetes, obesity, stroke, cancer, liver diseases and kidney diseases. Delicate contribution of ALDH enzymes in the therapeutics against chronic diseases is also discussed. It demonstrates the unique value of targeting genetic polymorphism in ALDH enzymes in personalized medicine. The book will appeal to scientists, physicians, graduate and professional students in the fields of ALDH enzymes, alcohol metabolism, cardiometabolic and other chronic diseases. Pharmaceutical and other companies developing new tools for cardiometabolic and chronic diseases treatment will also find this a valuable resource"--Publisher's description.
Note Description based on online resource; title from electronic title page (ProQuest Ebook Central, viewed January 22, 2020).
ISBN 9789811362606 electronic book
9811362602 electronic book
9789811362590 electronic book
9811362599 electronic book
9789811362590 hardcover
9811362629 hardcover
ISBN/ISSN 10.1007/978-981-13-6260-6
OCLC # 1114290668
Additional Format Print version: Aldehyde dehydrogenases. Singapore : Springer, [2019] 9789811362590 (OCoLC)1121097713

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