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EBOOK
Title Handbook of drug metabolism / edited by Thomas F. Woolf.
Imprint New York : Dekker, 1999.

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Subject Drugs -- Metabolism.
Pharmaceutical Preparations -- metabolism.
Alt Name Woolf, Thomas F., 1955-
Description 1 online resource (xi, 596 pages) : illustrations
Bibliography Note Includes bibliographical references and index.
Contents pt. 1. Fundamental aspects of drug metabolism -- Ch. 1. Pharmacokinetics of drug metabolites -- Ch. 2. Oxidative metabolic bioactivation of xenobiotics -- Ch. 3. Morphofunctional aspects of the hepatic architecture: functional and subcellular correlates -- Ch. 4. The cytochrome P450 oxidative system -- Ch. 5. Transformation enzymes: oxidative; non-P450 -- Ch. 6. Transformation reactions: glucuronidation -- pt. 2. Factors affecting drug metabolism -- Ch. 7. Pharmacogenetics.
Ch. 8. Inhibition of drug metabolizing enzymes: molecular and biochemical aspects -- Ch. 9. Metabolic drug interactions -- Ch. 10. Induction of human drug-metabolizing enzymes: mechanisms and implications -- Ch. 11. Sites of metabolism: lung -- Part 3. Technologies -- Ch. 12. Applications of heterologous expressed and purified human drug-metabolizing enzymes: an industrial perspective -- Ch. 13. In vivo and in vitro recombinant DNA technology as a powerful tool in drug development -- Ch. 14. In vitro metabolism: subcellular fractions.
Ch. 15. In vitro metabolism: hepatocytes -- Ch. 16. The isolated perfused liver as a tool in drug metabolism studies -- Ch. 17. Metabolic models of cytotoxicity -- Ch. 18. In vitro metabolism: FMO and related oxygenations -- Ch. 19. Applications of Caco-2 cells in drug discovery and development -- Ch. 20. The role of nuclear magnetic resonance spectroscopy in drug metabolism -- pt. 4. Metabolism in drug discovery and development -- Ch. 21. Preclinical drug metabolism studies and strategies -- Ch. 22. Clinical drug metabolism studies.
Note Print version record.
ISBN 0585109796 (electronic bk.)
9780585109794 (electronic bk.)
1420000594
9781420000597
9780824702298
9781420000597
0824702298
OCLC # 44958793
Additional Format Print version: Handbook of drug metabolism. New York : Dekker, 1999 0824702298 (DLC) 99017637 (OCoLC)40881480
Table of Contents
 Preface 
 Contributors 
Pt. 1Fundamental Aspects of Drug Metabolism 
 1Pharmacokinetics of Drug Metabolites / Philip C. Smith1
 2Oxidative Metabolic Bioactivation of Xenobiotics / Stephane Mabic, Kay Castagnoli, Neal Castagnoli, Jr.49
 3Morphofunctional Aspects of the Hepatic Architecture: Functional and Subcellular Correlates / Felix A. de la Iglesia, Donald G. Robertson, Jeffrey R. Haskins81
 4The Cytochrome P450 Oxidative System / Paul R. Ortiz de Montellano109
 5Transformation Enzymes: Oxidative; Non-P450 / Allen E. Rettie, Michael B. Fisher131
 6Transformation Reactions: Glucuronidation / Brian Burchell153
Pt. 2Factors Affecting Drug Metabolism 
 7Pharmacogenetics / Ann K. Daly175
 8Inhibition of Drug Metabolizing Enzymes: Molecular and Biochemical Aspects / F. Peter Guengerich203
 9Metabolic Drug Interactions / Wayne D. Hooper229
 10Induction of Human Drug-Metabolizing Enzymes: Mechanisms and Implications / Martin J. J. Ronis, Magnus Ingelman-Sundberg239
 11Sites of Metabolism: Lung / Garold S. Yost263
Pt. 3Technologies 
 12Applications of Heterologous Expressed and Purified Human Drug-Metabolizing Enzymes: An Industrial Perspective / A. David Rodrigues279
 13In Vivo and In Vitro Recombinant DNA Technology as a Powerful Tool in Drug Development / Thomas Friedberg, C. J. Henderson, M. P. Pritchard [et al.]321
 14In Vitro Metabolism: Subcellular Fractions / Sean Ekins, Jukka Maenpaa, Steven A. Wrighton363
 15In Vitro Metabolism: Hepatocytes / Michael W. Sinz401
 16The Isolated Perfused Liver as a Tool in Drug Metabolism Studies / Marian Kukan425
 17Metabolic Models of Cytotoxicity / Munir Pirmohamed, B. Kevin Park443
 18In Vitro Metabolism: FMO and Related Oxygenations / John R. Cashman477
 19Applications of Caco-2 Cells in Drug Discovery and Development / Shiyin Yee, Wesley W. Day507
 20The Role of Nuclear Magnetic Resonance Spectroscopy in Drug Metabolism / I. D. Wilson, J. K. Nicholson, J. C. Lindon523
Pt. 4Metabolism in Drug Discovery and Development 
 21Preclinical Drug Metabolism Studies and Strategies / Philip B. Inskeep, Wesley W. Day551
 22Clinical Drug Metabolism Studies / William F. Pool577
 Index589


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