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Title Perioperative inflammation as triggering oigin of metastasis development / Michael W. Retsky, Romano Demicheli, editors.
Imprint Cham, Switzerland : Springer, [2017]

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Subject Breast -- Cancer.
Breast -- Radiography.
Breast Neoplasms.
Alt Name Retsky, Michael W.,
Demicheli, Romano,
Description 1 online resource
Contents Foreword; Preface; Contents; Contributors; Introduction; Chapter 1: The Natural History of Breast Cancer; 1.1 Introduction; 1.2 The Nature of Models and Models of Nature; 1.2.1 The Natural History of a Rose; 1.2.2 Breast Cancer; 1.2.3 Breast Cancer in the Nineteenth Century and Early Twentieth Century; 1.2.4 The Influence of Surgery on the Natural History of Breast Cancer; 1.2.5 The Biological Revolution of the Late Twentieth Century; 1.2.6 Phenomena that Challenge the Existing Models; Local Treatment; 1.2.7 Adjuvant Systemic Therapy Has Only a Modest Effect on Survival.
2.14 Concerns About Bleeding Complications2.15 Summary; 2.16 Conclusions; References; Chapter 3: Peri-operative Shift in Angiogenesis-Related Factors in Breast Cancer Patients; 3.1 Study Outline; 3.2 Special Considerations Regarding Study Design; 3.2.1 VEGF (Vascular Endothelial Growth Factor); 3.2.2 IL-8 (Ιnterleukin-8); 3.2.3 bFGF (Basic Fibroblast Growth Factor); 3.3 Comparative Analysis of Angiogenesis-Related Genes Between Patients with Breast Cancer and Fibroadenoma Using Quantitative Real Time PCR; 3.3.1 Study Group vs Control Group Before Surgery (PRO).
1.2.8 When Does a Primary Tumour Seed Its Secondaries?1.2.9 A new Model to Explain the Natural History of Breast Cancer; 1.2.10 The Nature of Beauty and the Beauty of Nature; References; Chapter 2: Perioperative Inflammation as Triggering Origin of Metastasis Development; 2.1 Introduction; 2.2 Milan Data Showing Early Bimodal Relapse Pattern That Started This Investigation; 2.3 Multipeak Relapse Data Suggest Continuous Growth Is Not a Correct Description of Spontaneous Cancers; 2.4 Library Research at University of Texas-San Antonio; 2.5 Ingleby and Moore Data.
2.6 It Seems We Have Rediscovered a Problem That Was Known to Surgeons 2000 Years Ago2.7 Clinical Correlations to Suggested Surgery Induced Metastatic Activity; 2.8 Surprising Development from a Belgian Anesthesiology Group; 2.9 Our Attention Is Drawn to Inflammation; 2.10 Possible Mechanisms for a Post-surgical Systemic Inflammatory Reaction to Drive Tumor Growth; 2.11 TNBC and Early Relapses: Possibly an Ideal Group for Testing Perioperative Ketorolac; 2.12 Current Activities; 2.12.1 Focus on India and Nigeria; 2.13 Analysis of Data from Norway on Relapse Hazard After Delayed Reconstruction.
3.4 Comparative Analysis of Angiogenesis-Related Genes in Patients with Breast Cancer (Study Group) Before Surgery (PRO) and on Post-operative Day 3 (D3)3.5 Comparative Analysis of Angiogenesis-Related Genes in Patients with Breast Cancer (Study Group) Between Post-operative Day 3 (D3) and Post-operative Day 7 (D7); 3.6 Conclusions; References; Chapter 4: Perioperative Biologic Perturbation and Cancer Surgery: Targeting the Adrenergic-Inflammatory Response and Microcirculatory Dysregulation; 4.1 Introduction; 4.2 Importance of the Perioperative Period to Cancer Outcomes.
Bibliography Note Includes bibliographical references.
Summary The book will explain previously unconnected clinical data such as why mammography works better for women age 50-59 than it does for women age 40-49, why adjuvant chemotherapy works best for premenopausal patients with positive lymph nodes, and it may also explain the racial disparity in outcome. In particular, it points to the perioperative period when systemic inflammation persists for a week or so. This can lead to a variety of mechanisms whereby single cancer cells (perhaps from the marrow) begin division and angiogenesis of dormant avascular micrometastases occurs leading to early relapses. With chapters presented from distinguished scientists and physicians in a variety of specialties that relate to and border the effects we present, this volume can be used as a reference for practicing physicians and as a jumping-off point for researchers to explore new therapeutic opportunities.
Note Online resource; title from PDF title page (EBSCO, viewed July 11, 2017).
ISBN 9783319579436 (electronic bk.)
3319579436 (electronic bk.)
ISBN/ISSN 10.1007/978-3-319-57943-6
OCLC # 992436790
Additional Format Printed edition: 9783319579429

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