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Author Green, John William, 1943-
Title Statistical analysis of ecotoxicity studies / by John W. Green, Ph. D., Timothy A. Springer, Ph. D., Henrik Holbech, Ph. D.
Imprint Hoboken, NJ : John Wiley & Sons, 2018.
Edition First edition.

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Author Green, John William, 1943-
Subject Environmental toxicology -- Statistical methods.
Toxicity testing -- Statistical methods.
Alt Name Springer, Timothy A., 1948 March 3-
Holbech, Henrik, 1969-
Description 1 online resource
Edition First edition.
Contents An introduction to toxicity experiments -- Statistical analysis basics -- Analysis of continuous data : NOECs -- Analysis of continuous data : regression -- Analysis of continuous data with additional factors -- Analysis of quantal data : NOECs -- Analysis of quantal data : regression models -- Analysis of count data : NOEC and regression -- Analysis of ordinal data -- Time to event data -- Regulatory issues -- Species sensitivity distributions -- Studies with greater complexity.
Note Print version record and CIP data provided by publisher.
Bibliography Note Includes bibliographical references and index.
Summary A guide to the issues relevant to the design, analysis, and interpretation of toxicity studies that examine chemicals for use in the environment Statistical Analysis of Ecotoxicity Studies offers a guide to the design, analysis, and interpretation of a range of experiments that are used to assess the toxicity of chemicals. While the book highlights ecotoxicity studies, the methods presented are applicable to the broad range of toxicity studies. The text contains myriad datasets (from laboratory and field research) that clearly illustrate the book's topics. The datasets reveal the techniques, pitfalls, and precautions derived from these studies. The text includes information on recently developed methods for the analysis of severity scores and other ordered responses, as well as extensive power studies of competing tests and computer simulation studies of regression models that offer an understanding of the sensitivity (or lack thereof) of various methods and the quality of parameter estimates from regression models. The authors also discuss the regulatory process indicating how test guidelines are developed and review the statistical methodology in current or pending oeCD and USEPA ecotoxicity guidelines. This important guide: -Offers the information needed for the design and analysis to a wide array of ecotoxicity experiments and to the development of international test guidelines used to assess the toxicity of chemicals -Contains a thorough examination of the statistical issues that arise in toxicity studies, especially ecotoxicity -Includes an introduction to toxicity experiments and statistical analysis basics -Includes programs in R and excel -Covers the analysis of continuous and Quantal data, analysis of data as well as Regulatory Issues -Presents additional topics (Mesocosm and Microplate experiments, mixtures of chemicals, benchmark dose models, and limit tests) as well as software Written for directors, scientists, regulators, and technicians, Statistical Analysis of Ecotoxicity Studies provides a sound understanding of the technical and practical issues in designing, analyzing, and interpreting toxicity studies to support or challenge chemicals for use in the environment.
ISBN 9781119488828 (pdf)
9781119488811 (epub)
9781119088349 (cloth)
OCLC # 1029791027
Additional Format Print version: Green, John William, 1943- Statistical analysis of ecotoxicity studies. First edition. Hoboken, NJ : John Wiley & Sons, 2018 9781119088349 (DLC) 2018008775

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