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Title Understanding the process of aging : the roles of mitochondria, free radicals, and antioxidants / edited by Enrique Cadenas, Lester Packer.
Imprint New York : Marcel Dekker, 1999.

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Series Oxidative stress and disease ; 2
Oxidative stress and disease ; 2.
Subject Mitochondrial pathology.
Mitochondrial DNA.
Aging -- Physiological aspects.
Free radicals (Chemistry) -- Pathophysiology.
Active oxygen in the body.
Antioxidants -- Physiological effect.
Aging -- physiology.
DNA, Mitochondrial -- physiology.
Free Radicals.
Mitochondria -- metabolism.
Reactive Oxygen Species.
Alt Name Cadenas, Enrique.
Packer, Lester.
Description 1 online resource (xv, 366 pages) : illustrations.
Bibliography Note Includes bibliographical references and index.
Contents The mitochondrial production of oxygen radicals and cellular aging / Alberto Boveris -- Walking a tightrope: the balance between mitochondrial generation and scavenging of superoxide anion / David M. Guidot -- The biochemistry of nitric oxide and peroxynitrite: implications for mitochondrial function / Rakesh P. Patel -- Oxygen-dependent regulation of biological functions by nitric oxide / Kozo Utsumi -- Production of reactive oxygen species in mitochondria and age-assoiciated pathophysiology: a reality check / Henry Jay Forman -- Functional roles of ubiquinone / Jeffery R. Schultz -- Mitochondrial generation of reactive oxygen species and oxidative damage during aging: roles of coenzyme Q and tocopherol / Rajindar S. Sohal -- Mitochondria and aging: the mouse's tale / Steve Esworthy -- Mitochondria and apoptosis / Bernard M. Babior -- Role of mitochondria in oxidative stress associated with aging and apoptosis: studies in intact cells / Juan Sastre -- The role of iron and mitochondria in aging / Patrick B. Walter -- The mitochondrial-lysosomal axis theory of cellular aging / Ulf T. Brunk -- Quantitative analysis of mutations of mitochondrial DNA during human aging / Jorg Napiwotzki -- Oxidative damage and fragility of mitochondrial DNA / Takayuki Ozawa -- Mitochondria in cellular aging and degeneration / Gino A. Cortopassi -- Mitochondrial alteration in aging and inflammation: a possible site of action of nitrone-based free radical traps / Kenneth Hensley -- Muscle mitochondrial transmembrane processes in mitochondriocytopathies / Marjan Huizing.
Note Print version record.
ISBN 0585134103 (electronic bk.)
9780585134109 (electronic bk.)
0824717236 (alk. paper)
OCLC # 44953709
Additional Format Print version: Understanding the process of aging. New York : Marcel Dekker, 1999 0824717236 (DLC) 98055663 (OCoLC)40555875
Table of Contents
 Series Introduction / Lester Packer, Enrique Cadenas 
1The Mitochondrial Production of Oxygen Radicals and Cellular Aging / Alberto Boveris, Lidia E. Costa, Enrique Cadenas1
2Walking a Tightrope: The Balance Between Mitochondrial Generation and Scavenging of Superoxide Anion / David M. Guidot, Joe M. McCord17
3The Biochemistry of Nitric Oxide and Peroxynitrite: Implications for Mitochondrial Function / Rakesh P. Patel, Trudy Cornwell, Victor M. Darley-Usmar39
4Oxygen-Dependent Regulation of Biological Functions by Nitric Oxide / Kozo Utsumi, Yoshiki Takehara, Yoko Inai [et al.]57
5Production of Reactive Oxygen Species in Mitochondria and Age-Associated Pathophysiology: A Reality Check / Henry Jay Forman, Angelo Azzi73
6Functional Roles of Ubiquinone / Jeffery R. Schultz, Catherine Freitag Clarke95
7Mitochondrial Generation of Reactive Oxygen Species and Oxidative Damage During Aging: Roles of Coenzyme Q and Tocopherol / Rajindar S. Sohal, Achim Lass, Liang-Jun Yan [et al.]119
8Mitochondria and Aging: The Mouse's Tale / Steve Esworthy143
9Mitochondria and Apoptosis / Bernard M. Babior, Roberta A. Gottlieb, Christoph Richter167
10Role of Mitochondria in Oxidative Stress Associated with Aging and Apoptosis: Studies in Intact Cells / Juan Sastre, Federico V. Pallardo, Jose Garcia de la Asuncion [et al.]181
11The Role of Iron and Mitochondria in Aging / Patrick B. Walter, Kenneth B. Beckman, Bruce N. Ames203
12The Mitochondrial-Lysosomal Axis Theory of Cellular Aging / Ulf T. Brunk, Alexei Terman229
13Quantitative Analysis of Mutations of Mitochondrial DNA During Human Aging / Jorg Napiwotzki, Annette Reith, Andreas Becker [et al.]251
14Oxidative Damage and Fragility of Mitochondrial DNA / Takayuki Ozawa265
15Mitochondria in Cellular Aging and Degeneration / Gino A. Cortopassi, Alice Wong293
16Mitochondrial Alteration in Aging and Inflammation: A Possible Site of Action of Nitrone-Based Free Radical Traps / Kenneth Hensley, Lindsay Maidt, C. A. Stewart [et al.]311
17Muscle Mitochondrial Transmembrane Processes in Mitochondriocytopathies / Marjan Huizing, J. M. F. Trijbels, J. A. M. Smeitink [et al.]327

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