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Title Complement activation in malaria immunity and pathogenesis / Jose A. Stoute, editor.
Imprint Cham, Switzerland : Springer, [2018]

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Subject Complement activation.
Malaria -- Pathogenesis.
Malaria -- Immunological aspects.
Alt Name Stoute, José A.,
Description 1 online resource : color illustrations
polychrome rdacc
Bibliography Note Includes bibliographical references and index.
Contents Intro; Dedication; Preface; Contents; Contributors; The Complement System; Introduction; Classical Pathway; Lectin Pathway; Alternative Pathway; Terminal Complement Activation; Extrinsic Complement Activation Pathways; Anaphylatoxins; Complement Regulators; Soluble Complement Regulators; Surface-Bound Complement Regulators; Complement Receptors; References; Mechanisms of Complement Activation in Malaria; Introduction; Malaria Biology; Measures of Complement Activation; Immune Complexes Activate the CP of Complement.
IC-mediated Complement Activation, Complement Control Proteins, and Fcγ ReceptorsComplement Is Activated by Infected E and by E Breakdown Products; Activation of the AP of Complement Can Opsonize Uninfected E with C3b: Potential Consequences; Paroxysmal Nocturnal Hemoglobinuria (PNH) as a Model for Extravascular Clearance of C3d-Opsonized E; Additional Evidence for Activation of the Alternative Pathway; Acidemia: Another Possible Activator of Complement; Complement Activation by the MBL Pathway; Changes in the Spleen Possibly Mediated by Complement During Malarial Infections: Speculations.
Complement and Malaria/Cerebral MalariaComplement in Murine Models of Cerebral Malaria; Complement Gene-Targeted and Transgenic Mice in ECM; Classical Pathway; Lectin Pathway; Alternative Pathway; Anaphylatoxin Receptors and Anaphylatoxins; C3 and C5; Terminal Pathway; Complement Phagocytic Receptors and Regulatory Proteins; Integrating the Role of Complement in ECM; Complement-Mediated Therapeutic Approaches to Cerebral Malaria; References; Complement and Malaria in Pregnancy; Global Burden of Malaria Infection During Pregnancy; Pathophysiology of Malaria in Pregnancy.
The Role of Complement Activation in Pregnancy ComplicationsComplement Activation in Pregnancy; Complement in Non-malarial Pregnancy Pathologies; The Role of Complement Activation in Malaria in Pregnancy; Emerging Evidence of Complement Activation in MiP and Fetal Neurodevelopment; Therapeutic Potential of Targeting Complement Activation in MiP; Conclusions; References; Complement Evasion Mechanisms of the Human Pathogen Plasmodium falciparum; Merozoite Invasion into Red Blood Cells; Merozoite Surface Proteins; 6-Cysteine Family of Merozoite Surface Proteins.
Summary References; Role of Complement in Severe Malarial Anemia; The Problem of Severe Malarial Anemia; Evidence of Complement Activation During Malaria; Evidence of Opsonoization and Changes in the Expression of Complement Regulatory Proteins on Uninfected Erythrocytes of Patients with Malaria; Genetic Association Studies; Directions for Future Research; References; Role of Complement in Cerebral Malaria; The Impact of Malaria/Cerebral Malaria; Clinical Features of Cerebral Malaria; Molecular Features of CM; Complement Synthesis in the Periphery and Central Nervous System.
Note Online resource; title from PDF title page (EBSCO, viewed July 13, 2018).
ISBN 9783319772585 (electronic bk.)
3319772589 (electronic bk.)
ISBN/ISSN 10.1007/978-3-319-77258-5
OCLC # 1043830975
Additional Format Print version: Complement activation in malaria immunity and pathogenesis. Cham, Switzerland : Springer, [2018] 3319772570 9783319772578 (OCoLC)1022789499.

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