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Title Translational research methods for diabetes, obesity, and nonalcoholic fatty liver disease : a focus on early phase clinical drug development / editors, Andrew J. Krentz, Christian Weyer and Marcus Hompes.
Imprint Cham, Switzerland : Springer, 2019.
Edition Second edition.

View online
View online
Subject Drug development -- Research -- Methodology.
Diabetes -- Research -- Methodology.
Obesity -- Research -- Methodology.
Fatty liver -- Research -- Methodology.
Diabetes Mellitus -- drug therapy.
Obesity -- drug therapy.
Clinical Trials, Phase I as Topic -- methods.
Clinical Trials, Phase II as Topic -- methods.
Translational Medical Research.
Alt Name Krentz, Andrew J.,
Weyer, Christian,
Hompesch, Marcus,
Description 1 online resource
Edition Second edition.
Note Includes index.
Online resource; title from PDF title page (EBSCO, viewed April 3, 2019).
Summary This book reviews techniques for assessing insulin action, insulin secretion and body composition, with reference to new drugs, in phase 1 & 2 studies. Adds to understanding of drug effects and non-drug treatment strategies in obesity and type 2 diabetes.
Contents Part 1: Review of Clinical Investigative Methods Chapter 1: Quantifying Insulin Action in Humans Chapter 2: Assessment of Islet Alpha- and Beta-Cell Function Chapter 3: Pharmacokinetic and Pharmacodynamic Assessment of Novel and Biosimilar Insulins Chapter 4: Measurement of Energy Expenditure Chapter 5: QUANTIFYING APPETITE AND SATIETY Chapter 6: Non-invasive quantitative magnetic resonance imaging and spectroscopic biomarkers in nonalcoholic fatty liver disease and other cardiometabolic diseases associated with ectopic fat deposition Chapter 7: Structural and Functional Imaging of Muscle, Heart, Endocrine Pancreas and Kidneys in Cardiometabolic Drug Development Chapter 8: Positron emission tomography and computed tomography measurement of brown fat thermal activation: key tool for developing novel pharmacotherapeutics for obesity and diabetes Chapter 9: Isotopic Tracers for the Measurement of Metabolic Flux Rates Chapter 10: Role of Tissue Biopsy in Drug Development for NonAlcoholic Fatty Liver Disease and Other Metabolic Disorders Chapter 11: Utility of Invasive and Non-invasive Cardiovascular Research Methodologies in Drug Development for Diabetes, Obesity and NAFLD/NASH Chapter 12: Omics: Potential role in early phase drug development Part 2: Preclinical Drug Development and Transitioning to Clinical Studies Chapter 13: Peptide Drug Design for Diabetes & Related Metabolic Diseases Chapter 14: ANIMAL MODELS OF TYPE 2 DIABETES, OBESITY AND NONALCOHOLIC STEATOHEPATITIS -- CLINICAL TRANSLATABILITY AND APPLICABILITY IN PRECLINICAL DRUG DEVELOPMENT Chapter 15: Drug Development for Diabetes Mellitus: Beyond Hemoglobin A1c Chapter 16: Emerging Circulating Biomarkers For The Diagnosis And Assessment Of Treatment Responses In Patients With Hepatic Fat Accumulation, Nash And Liver Fibrosis Chapter 17: Quantitative Approaches in Translational Cardiometabolic Research: An Overview Chapter 18: Transitioning from Preclinical to Clinical Drug Development Chapter 19: Regulatory Considerations for Early Study and Clinical Development of Drugs for Diabetes, Obesity, NonAlcoholic Steatohepatitis (NASH) and other Cardiometabolic Disorders Chapter 20: Early Phase Metabolic Research with Reference to Special Populations.
ISBN 9783030117481 (electronic bk.)
3030117480 (electronic bk.)
OCLC # 1091190297

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