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Author Ribatti, Domenico, 1956-
Title Judah Folkman : a biography / Domenico Ribatti.
Imprint Cham, Switzerland : Springer, 2018.

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Author Ribatti, Domenico, 1956-
Subject Folkman, M. Judah.
Medical scientists -- United States -- Biography.
Cancer -- Research.
Neovascularization -- Research.
Description 1 online resource
polychrome rdacc
Bibliography Note Includes bibliographical references.
Summary The aim if this book is to analyze the scientific biography of Judah Folkman, one of the most important scientist of the last century. More 50 years ago, Folkman found a revolutionary new way to think about cancer. Blood supply, Folkman hypothesized, was the key to tumor growth. Without new blood vessels, tumors simply did not thrive. In 1971, Folkman published his theory of angiogenesis in the "New England Journal of Medicine". Angiogenesis, the formation and recruitment of new blood vessels, is necessary for tumor growth. Critics of the theory were silenced over time as Folkman and his colleagues reported the first purified angiogenic molecule, the first angiogenesis inhibitor and proposed the concept of angiogenic disease. The mechanism of angiogenesis is now a worldwide field of investigation. Over the years, Folkman and a growing team of researchers have isolated the proteins and unraveled the processes that regulate angiogenesis. Meanwhile, a new generation of angiogenesis research has emerged as well, widening the field into new areas of human disease and deepening it to examine the underlying biological processes responsible for those diseases.
Contents Intro; Abstract; Contents; Chapter 1: Biographic Profile; 1.1 Awards; References; Chapter 2: Development ofAssays toStudy Angiogenesis; 2.1 The Rabbit Cornea; 2.2 The Chorioallantoic Membrane; 2.3 Culture ofEndothelial Cells; References; Chapter 3: Tumor Angiogenesis; 3.1 Early Evidence That Tumor Cells Release Specific Growth Factors forEndothelial Cells; 3.2 Absence ofAngiogenesis inTumors inIsolated Perfused Organs; 3.3 Tumor Growth Is Angiogenesis Dependent; 3.4 The Concept ofAngiogenic Switch; 3.5 The Avascular andVascular Phases ofSolid Tumor Growth.
3.6 Angiogenesis andMetastasis3.7 Prognostic Significance ofTumor Vascularity; References; Chapter 4: The Discovery ofAngiogenesis Factors; 4.1 Isolation oftheFirst Tumor Angiogenic Tumor; 4.2 The Discovery ofFGF; 4.3 The Discovery ofVPF/VEGF; References; Chapter 5: Anti-angiogenesis; 5.1 Inhibition ofAngiogenesis bya Diffusibile Factor fromCartilage; 5.2 Endogenous, Direct andIndirect Inhibitors; 5.3 Interferon Alpha; 5.4 Platelet Factor 4/Protamine; 5.5 Angiostatic Steroids; 5.6 Fumagillin; 5.7 Angiostatin andEndostatin; 5.8 Thalidomide.
5.9 2-Methoxyestradiol andCleaved Antithrombin III5.10 Anti-angiogenic Chemotherapy; References; Chapter 6: Concluding Remarks; References; Chapter 7: Publications ofJudah Folkman (2014-1956).
Note Online resource; title from PDF title page (EBSCO, viewed June 27, 2018).
ISBN 9783319926339 (electronic bk.)
3319926330 (electronic bk.)
ISBN/ISSN 10.1007/978-3-319-92633-9
OCLC # 1041937715
Additional Format Print version: Ribatti, Domenico, 1956- Judah Folkman. Cham, Switzerland : Springer, 2018 3319926322 9783319926322 (OCoLC)1033477470

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