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LEADER 00000cam 2200613Ii 4500
001 1089253669
003 OCoLC
005 20190808063646.7
006 m o d
007 cr cnu|||unuuu
008 190306s2019 sz a o 001 0 eng d
015 GBB948731|2bnb
019 1089777119
020 9783030052225|q(electronic bk.)
020 3030052222|q(electronic bk.)
020 |z9783030052218|q(print)
020 |z3030052214
024 7 10.1007/978-3-030-05222-5|2doi
035 (OCoLC)1089253669|z(OCoLC)1089777119
037 com.springer.onix.9783030052225|bSpringer Nature
040 GW5XE|beng|erda|epn|cGW5XE|dEBLCP|dYDX|dUKMGB|dCOO|dOCLCQ
049 MAIN
050 4 RE661.D3
082 04 617.7/35|223
245 00 Cell-based therapy for degenerative retinal disease /
|cMarco A. Zarbin, Mandeep S. Singh, Ricardo P. Casaroli-
Marano, editors.
264 1 Cham, Switzerland :|bHumana Press,|c2019.
300 1 online resource (xi, 280 pages) :|billustrations (some
color).
336 text|btxt|2rdacontent
337 computer|bc|2rdamedia
338 online resource|bcr|2rdacarrier
340 |gpolychrome|2rdacc|0http://rdaregistry.info/termList/
RDAColourContent/1003
347 text file|2rdaft|0http://rdaregistry.info/termList/
fileType/1002
490 1 Stem cell biology and regenerative medicine,|x2196-8985.
500 Includes index.
505 0 Intro; Preface; Contents; Contributors; Chapter 1:
Advantages of the Eye as a Target Organ for Cell-Based
Therapy in the Central Nervous System; Introduction;
Advantages of the Eye as a Target Organ; Anatomy and
Physiology; Surgical Access; Immune Privilege; Antigen
Load; High-Resolution Noninvasive Imaging Technology;
Functional Assessment of the Transplant; Conclusions;
References; Chapter 2: Proof of Principle: Preclinical
Data on Retinal Cell Transplantation; Introduction;
Photoreceptor Rescue Therapy; RPE Transplantation; Neural
and Retinal Progenitor Cell Transplantation
505 8 Bone Marrow Cell TransplantationUmbilical Tissue-Derived
Cell Transplantation; Photoreceptor Replacement Therapy;
Neuroretinal Sheet Transplantation; Photoreceptor Cell
Transplantation; Retinal Cellular Materials Transfer;
Conclusion; References; Chapter 3: Clinical and
Pathological Features of Selected Human Retinal
Degenerative Diseases; Introduction; Generalized Retinal
Degenerations; Retinitis Pigmentosa; Clinical
Characteristics; Genetic Associations and Pathophysiology;
Ophthalmoscopic Features; Imaging and Other Useful Tests;
Perimetry and Electrophysiological Testing
505 8 Fundus AutofluorescenceFluorescein Angiography; Optical
Coherence Tomography (OCT); Differential Diagnosis; Leber
Congenital Amaurosis; Clinical Characteristics; Genetic
Association and Pathophysiology; Ophthalmoscopic Features;
Imaging and Other Useful Tests; Fundus Autofluorescence,
Fluorescein Angiography, and OCT; Psychophysical and
Electrophysiological Testing; Differential Diagnosis;
Choroideremia; Clinical Characteristics; Genetic
Association and Pathophysiology; Ophthalmoscopic Features;
Imaging and Other Useful Tests; Differential Diagnosis;
Central Degenerations
505 8 Age-Related Macular DegenerationClinical Characteristics;
Genetic Association and Pathophysiology; Ophthalmoscopic
Features; Imaging and Other Useful Tests; Fluorescein
Angiography; Optical Coherence Tomography; Fundus
Autofluorescence; Electrophysiological Testing;
Differential Diagnosis; ABCA4 (Stargardt) Dystrophy;
Clinical Characteristics; Genetic Association and
Pathophysiology; Ophthalmoscopic Features; Imaging and
Other Useful Tests; Fundus Autofluorescence; Fluorescein
Angiography; Optical Coherence Tomography;
Electrophysiological Testing; Differential Diagnosis; Best
Disease
505 8 Clinical CharacteristicsGenetic Association and
Pathophysiology; Ophthalmoscopic Features; Imaging and
Other Useful Tests; Optical Coherence Tomography; Fundus
autofluorescence; Fluorescein Angiography;
Electrophysiological Testing; Differential Diagnosis;
Conclusion; References; Chapter 4: Degenerative Retinal
Diseases: Cell Sources for Cell-Based Therapy; Retinal
Degenerative Diseases; Sources of Stem Cells; Embryonic
Stem Cells (ESCs); Fetal Stem Cells; Adult Stem Cells;
Neuronal Origin; RPE Stem Cells; Ciliary Epithelium-
Derived Progenitor Cells; Muller Progenitor Cells (MCs)
520 This book discusses why specific diseases are being
targeted for cell-based retinal therapy, what evidence
exists that justifies optimism for this approach, and what
challenges must be managed in order to bring this
technology from the laboratory into routine clinical
practice. There are a number of unanswered questions (e.g.,
surgical approach to cell delivery, management of immune
response, optimum cell type to transplant) that very
likely are not going to be answered until human trials are
undertaken, but there is a certain amount of "de-risking"
that can be done with preclinical experimentation. This
book is essential reading for scientists, clinicians, and
advanced students in stem cell research, cell biology, and
ophthalmology.
588 0 Online resource; title from PDF title page (SpringerLink,
viewed March 6, 2019).
650 0 Retinal degeneration|0http://id.loc.gov/authorities/
subjects/sh85113332|xTreatment.|0http://id.loc.gov/
authorities/subjects/sh99005040
650 0 Stem cells|0http://id.loc.gov/authorities/subjects/
sh85127923|xTherapeutic use.|0http://id.loc.gov/
authorities/subjects/sh2001008985
655 4 Electronic books.
700 1 Zarbin, Marco A.,|0http://id.loc.gov/authorities/names/
n86857334|eeditor.
700 1 Singh, Mandeep,|cMD,|0http://id.loc.gov/authorities/names/
nb2007019979|eeditor.
700 1 Casaroli-Marano, Ricardo Pedro,|0http://id.loc.gov/
authorities/names/no2009186614|eeditor.
776 08 |iPrint version:|tCell-based therapy for degenerative
retinal disease.|dCham, Switzerland : Humana Press, 2019
|z3030052214|z9783030052218|w(OCoLC)1061049011.
830 0 Stem cell biology and regenerative medicine.|0http://
id.loc.gov/authorities/names/no2009070650|x2196-8985.
990 SpringerLink|bSpringer English/International eBooks 2019 -
Full Set|c2019-08-07|yNew collection
springerlink.ebooks2019|5OH1
| ||||||||||||
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