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LEADER 00000cam  2200613Ii 4500 
001    1089253669 
003    OCoLC 
005    20190808063646.7 
006    m     o  d         
007    cr cnu|||unuuu 
008    190306s2019    sz a    o     001 0 eng d 
015    GBB948731|2bnb 
019    1089777119 
020    9783030052225|q(electronic bk.) 
020    3030052222|q(electronic bk.) 
020    |z9783030052218|q(print) 
020    |z3030052214 
024 7  10.1007/978-3-030-05222-5|2doi 
035    (OCoLC)1089253669|z(OCoLC)1089777119 
037    com.springer.onix.9783030052225|bSpringer Nature 
040    GW5XE|beng|erda|epn|cGW5XE|dEBLCP|dYDX|dUKMGB|dCOO|dOCLCQ 
049    MAIN 
050  4 RE661.D3 
082 04 617.7/35|223 
245 00 Cell-based therapy for degenerative retinal disease /
       |cMarco A. Zarbin, Mandeep S. Singh, Ricardo P. Casaroli-
       Marano, editors. 
264  1 Cham, Switzerland :|bHumana Press,|c2019. 
300    1 online resource (xi, 280 pages) :|billustrations (some 
       color). 
336    text|btxt|2rdacontent 
337    computer|bc|2rdamedia 
338    online resource|bcr|2rdacarrier 
340    |gpolychrome|2rdacc|0http://rdaregistry.info/termList/
       RDAColourContent/1003 
347    text file|2rdaft|0http://rdaregistry.info/termList/
       fileType/1002 
490 1  Stem cell biology and regenerative medicine,|x2196-8985. 
500    Includes index. 
505 0  Intro; Preface; Contents; Contributors; Chapter 1: 
       Advantages of the Eye as a Target Organ for Cell-Based 
       Therapy in the Central Nervous System; Introduction; 
       Advantages of the Eye as a Target Organ; Anatomy and 
       Physiology; Surgical Access; Immune Privilege; Antigen 
       Load; High-Resolution Noninvasive Imaging Technology; 
       Functional Assessment of the Transplant; Conclusions; 
       References; Chapter 2: Proof of Principle: Preclinical 
       Data on Retinal Cell Transplantation; Introduction; 
       Photoreceptor Rescue Therapy; RPE Transplantation; Neural 
       and Retinal Progenitor Cell Transplantation 
505 8  Bone Marrow Cell TransplantationUmbilical Tissue-Derived 
       Cell Transplantation; Photoreceptor Replacement Therapy; 
       Neuroretinal Sheet Transplantation; Photoreceptor Cell 
       Transplantation; Retinal Cellular Materials Transfer; 
       Conclusion; References; Chapter 3: Clinical and 
       Pathological Features of Selected Human Retinal 
       Degenerative Diseases; Introduction; Generalized Retinal 
       Degenerations; Retinitis Pigmentosa; Clinical 
       Characteristics; Genetic Associations and Pathophysiology;
       Ophthalmoscopic Features; Imaging and Other Useful Tests; 
       Perimetry and Electrophysiological Testing 
505 8  Fundus AutofluorescenceFluorescein Angiography; Optical 
       Coherence Tomography (OCT); Differential Diagnosis; Leber 
       Congenital Amaurosis; Clinical Characteristics; Genetic 
       Association and Pathophysiology; Ophthalmoscopic Features;
       Imaging and Other Useful Tests; Fundus Autofluorescence, 
       Fluorescein Angiography, and OCT; Psychophysical and 
       Electrophysiological Testing; Differential Diagnosis; 
       Choroideremia; Clinical Characteristics; Genetic 
       Association and Pathophysiology; Ophthalmoscopic Features;
       Imaging and Other Useful Tests; Differential Diagnosis; 
       Central Degenerations 
505 8  Age-Related Macular DegenerationClinical Characteristics; 
       Genetic Association and Pathophysiology; Ophthalmoscopic 
       Features; Imaging and Other Useful Tests; Fluorescein 
       Angiography; Optical Coherence Tomography; Fundus 
       Autofluorescence; Electrophysiological Testing; 
       Differential Diagnosis; ABCA4 (Stargardt) Dystrophy; 
       Clinical Characteristics; Genetic Association and 
       Pathophysiology; Ophthalmoscopic Features; Imaging and 
       Other Useful Tests; Fundus Autofluorescence; Fluorescein 
       Angiography; Optical Coherence Tomography; 
       Electrophysiological Testing; Differential Diagnosis; Best
       Disease 
505 8  Clinical CharacteristicsGenetic Association and 
       Pathophysiology; Ophthalmoscopic Features; Imaging and 
       Other Useful Tests; Optical Coherence Tomography; Fundus 
       autofluorescence; Fluorescein Angiography; 
       Electrophysiological Testing; Differential Diagnosis; 
       Conclusion; References; Chapter 4: Degenerative Retinal 
       Diseases: Cell Sources for Cell-Based Therapy; Retinal 
       Degenerative Diseases; Sources of Stem Cells; Embryonic 
       Stem Cells (ESCs); Fetal Stem Cells; Adult Stem Cells; 
       Neuronal Origin; RPE Stem Cells; Ciliary Epithelium-
       Derived Progenitor Cells; Muller Progenitor Cells (MCs) 
520    This book discusses why specific diseases are being 
       targeted for cell-based retinal therapy, what evidence 
       exists that justifies optimism for this approach, and what
       challenges must be managed in order to bring this 
       technology from the laboratory into routine clinical 
       practice. There are a number of unanswered questions (e.g.,
       surgical approach to cell delivery, management of immune 
       response, optimum cell type to transplant) that very 
       likely are not going to be answered until human trials are
       undertaken, but there is a certain amount of "de-risking" 
       that can be done with preclinical experimentation. This 
       book is essential reading for scientists, clinicians, and 
       advanced students in stem cell research, cell biology, and
       ophthalmology. 
588 0  Online resource; title from PDF title page (SpringerLink, 
       viewed March 6, 2019). 
650  0 Retinal degeneration|0http://id.loc.gov/authorities/
       subjects/sh85113332|xTreatment.|0http://id.loc.gov/
       authorities/subjects/sh99005040 
650  0 Stem cells|0http://id.loc.gov/authorities/subjects/
       sh85127923|xTherapeutic use.|0http://id.loc.gov/
       authorities/subjects/sh2001008985 
655  4 Electronic books. 
700 1  Zarbin, Marco A.,|0http://id.loc.gov/authorities/names/
       n86857334|eeditor. 
700 1  Singh, Mandeep,|cMD,|0http://id.loc.gov/authorities/names/
       nb2007019979|eeditor. 
700 1  Casaroli-Marano, Ricardo Pedro,|0http://id.loc.gov/
       authorities/names/no2009186614|eeditor. 
776 08 |iPrint version:|tCell-based therapy for degenerative 
       retinal disease.|dCham, Switzerland : Humana Press, 2019
       |z3030052214|z9783030052218|w(OCoLC)1061049011. 
830  0 Stem cell biology and regenerative medicine.|0http://
       id.loc.gov/authorities/names/no2009070650|x2196-8985. 
990    SpringerLink|bSpringer English/International eBooks 2019 -
       Full Set|c2019-08-07|yNew collection 
       springerlink.ebooks2019|5OH1 
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