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Title Recent advances in retinoblastoma treatment / Jasmine H. Francis, David H. Abramson, editors.
Imprint Cham : Springer, 2015.

View online
View online
Series Essentials in ophthalmology, 2196-890X.
Essentials in ophthalmology.
Subject Retinoblastoma -- Treatment.
Retinoblastoma -- therapy.
Alt Name Francis, Jasmine H.,
Abramson, David H.,
Description 1 online resource : illustrations (some color).
polychrome rdacc
Note Online resource; title from PDF title page (Ebsco, viewed July 28, 2015).
"The chapters in this book represent most of the lectures that were delivered at the elebration honoring 100 years of retinoblastoma in New York (1914-2014)"--Preface.
Bibliography Note Includes bibliographical references and index.
Summary This comprehensive resource on the current understanding of retinoblastoma addresses all of the essential aspects of retinoblastoma and its management, including: its molecular biology and genetics, management by intraarterial and intravitreal chemotherapy, electroretinogram monitoring of treatment, pharmacokinetic studies, high-risk features, treatment of metastatic disease, and long-term follow-up. The book represents a collaborative project involving ophthalmic oncologists, geneticists, pediatric oncologists, interventional neuroradiologists, electrophysiologists, and basic scientists who are at the forefront of their field. It is written in an accessible manner, and a wealth of tables, figures, and exemplary images are included to enhance the understanding of concepts.
Contents 1.4.1 Modulation of Rb Phosphorylation State1.4.2 Viral Oncoproteins; 1.4.3 Epigenetics and Imprinting; 1.5 Clinical Importance of Retinoblastoma Molecular Genetics; 1.5.1 Heritability; 1.5.2 Second Primary Tumors; 1.5.3 Age of Onset; 1.5.4 Retinocytoma and Low Penetrance Retinoblastoma; 1.5.5 Vitreous Seeding; 1.5.6 Future Treatments; 1.6 Conclusion; References; 2: Challenges of Genetic Susceptibility Testing for Retinoblastoma; 2.1 Introduction; 2.2 Definition of Genetic Counseling; 2.3 Referrals for Genetic Counseling in Retinoblastoma Clinics.
Preface; Contents; Contributors; 1: Molecular Biology of Retinoblastoma; 1.1 The First Tumor Suppressor; 1.2 Structural Biology of the Rb Pathway; 1.2.1 The RB1 Gene; 1.2.2 The Rb Phosphorotein; 1.3 Functions of the Rb Pathway; 1.3.1 Regulation of E2F-Responsive Gene Transcription; 1.3.2 Epigenetic Effects, Including Active Repression of Other Genes Through Chromatin Remodeling; 1.3.3 Cell Cycle Inhibition; 1.3.4 Maintenance of Cellular Differentiation; 1.3.5 Anti-apoptotic Function; 1.3.6 Maintenance of Chromosomal Stability; 1.4 Disruption of the Rb Pathway.
2.4 Elements of Genetic Counseling2.5 Components of Pre-test Genetic Counseling; 2.6 Genetic Testing and Types of RB1 Results; 2.7 Potential Risks of RB1 Testing; 2.8 Explanation of the Potential Benefits and Uses of RB1 Genetic Testing; 2.9 Referral to Prenatal Genetic Counselor and Options for Prenatal Testing; 2.10 Explanation of the Limitations of RB1 Genetic Testing; 2.11 Case Scenarios; 2.12 Other Considerations of RB1 Testing; 2.13 Components of Post-test Genetic Counseling; 2.14 Conclusion; References; 3: Technique of Ophthalmic Artery Chemosurgery for Retinoblastoma.
3.1 Introduction3.2 Material and Methods; 3.2.1 Patient Population; 3.2.2 Protocol; 3.2.3 Intra-arterial Chemotherapy Procedure; 3.3 Results; 3.4 Conclusion; References; 4: Vitreous Disease and the Technique, Safety and Toxicity of Intravitreal Chemotherapy for Retinoblastoma; 4.1 Vitreous Disease; 4.1.1 Dust; 4.1.2 Spheres; 4.1.3 Clouds; 4.2 Technique; 4.2.1 History; 4.2.2 Safety Enhancement; 4.2.3 Decreasing Needle Size and Volume of Drug; 4.2.4 Lowering Intraocular Pressure; 4.2.5 Injection Site Precautions; 4.2.6 Exclusion Criteria; 4.2.7 Irrigation/Water Submersion.
4.2.8 Ocular and Needle Washings4.2.9 Tethered Seeds; 4.3 Ocular Toxicity; 4.3.1 Electroretinogram: Clinical; 4.3.2 Electroretinogram: Preclinical; 4.3.3 Clinical Signs of Toxicity; 4.4 Systemic Toxicity; 4.5 Conclusion; References; 5: Electroretinogram Monitoring of Retinoblastoma Treatment; 5.1 Introduction; 5.2 Ophthalmic Artery Chemotherapy Infusion; 5.3 ERG Protocol; 5.4 ERG Testing Schedule; 5.5 ERG Recording During Examination Under Anesthesia: Technical Considerations; 5.5.1 Baseline Noise; 5.5.2 Effect of Ocular Manipulation on the ERG.
ISBN 9783319194677 (electronic bk.)
3319194674 (electronic bk.)
3319194666 (print)
9783319194660 (print)
ISBN/ISSN 10.1007/978-3-319-19467-7
OCLC # 914472219
Additional Format Printed edition: 9783319194660.

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