| Table of Contents |
| | Introduction / Claude Lenfant | |
| | Preface | |
| | Contributors | |
| 1 | Mechanism of Action of Antiinflammatory Drugs / John R. Vane, Regina M. Botting | 1 |
| 2 | Pathways of Arachidonate Metabolism / John C. McGiff, Michael Balazy | 25 |
| 3 | Cytochromes P450 and Arachidonic Acid Metabolism / Michael Balazy, John C. McGiff | 45 |
| 4 | Mechanisms of Isoprostane Biosynthesis in Humans / Paola Patrignani, Roberto Padovano, Maria Gina Sciulli [et al.] | 77 |
| 5 | Intracellular Localization of Eicosanoid-Forming Enzymes / Thomas G. Brock, Marc Peters-Golden | 91 |
| 6 | Cyclooxygenase-2 Expression in Airway Cells / Peter J. Barnes, Maria G. Belvisi, Robert Newton [et al.] | 111 |
| 7 | Cyclooxygenase Gene Expression and Regulation / Kenneth Kun-yu Wu | 129 |
| 8 | NSAID-Induced Apoptosis: A New Therapeutic Activity of Competitive Cyclooxygenase Inhibitors? / Daniel L. Simmons | 145 |
| 9 | The Three-Dimensional Structure of Cyclooxygenases / Daniel Picot | 161 |
| 10 | The Role of 5-Lipoxygenase Products in a Mouse Model of Allergic Airway Inflammation Charles G. [et al.] / Colin D. Funk, Xin-Sheng Chen | 187 |
| 11 | Genetic Influences on Asthma / William O. C. M. Cookson | 201 |
| 12 | Intrinsic Asthma / Leonardo M. Fabbri, Gaetano Caramori, Bianca Beghe [et al.] | 215 |
| 13 | Viral Infection and Asthma: The Modulatory Role of Nitric Oxide on Prostaglandin H Synthase / Gert Folkerts, Frans P. Nijkamp | 231 |
| 14 | The Pharmacology of Prostaglandin E[subscript 2]: Actions in Human Diseases Involving the Mast Cell / John A. Oates, John J. Murray, David D. Hagaman [et al.] | 253 |
| 15 | Eicosanoids in the Pathogenesis of Exercise- and Allergen-Induced Asthma / Paul M. O'Byrne | 259 |
| 16 | Endotoxin-Induced Acute Respiratory Distress Syndrome in Nitric Oxide-Deficient Rats / Pawel P. Wolkow, Ewa Janowska, Joanna B. Bartus [et al.] | 273 |
| 17 | Eicosanoid Regulation by Glucocorticoids in Asthma / Ryszard Dworski | 283 |
| 18 | Mechanisms of Aspirin-Induced Asthma / Andrzej Szczeklik | 299 |
| 19 | Leukotrienes in Aspirin-Sensitive Asthma / S. M. Shuaib Nasser, Tak H. Lee | 317 |
| 20 | Mast Cell and Eosinophil Responses After Indomethacin in Asthmatics Tolerant and Intolerant to Aspirin / Esther L. Langmack, Sally E. Wenzel | 337 |
| 21 | Aspects of Mechanisms in Aspirin-Intolerant Asthma / Barbro Dahlen | 351 |
| 22 | Aspirin-Intolerant Asthma: New Insights from Bronchial Mucosal Biopsies / Anthony P. Sampson | 371 |
| 23 | Pharmacological Intervention in Generation of Leukotrienes by Eosinophils / Klaus F. Rabe, Gordon Dent | 391 |
| 24 | Airway Ion Transport Mechanisms and Aspirin in Asthma / Sebastiano Bianco, Maria Robuschi, Andriano Vaghi [et al.] | 419 |
| 25 | Role of Autoantibodies Against Endothelial Cells in Severe Asthma / Philippe Lassalle, Michel Joseph, Andre-Bernard Tonnel | 439 |
| 26 | Clinical Course of Aspirin-Induced Asthma: Results of AIANE / Ewa Nizankowska, Mariusz Duplaga, Grazyna Bochenek [et al.] | 451 |
| 27 | Nasal Polyposis / Niels Mygind, Ronald Dahl, Per L. Larsen [et al.] | 473 |
| 28 | The Nose in Aspirin-Sensitive Asthma / Cesar Picado, Joaquim Mullol | 493 |
| 29 | The Role of Glucocorticoids in the Modulation of Eicosanoid Metabolism in Asthma / Isabelle Vachier, Pascal Chanez, Claude Chavis [et al.] | 507 |
| 30 | Desensitization in Aspirin-Induced Asthma / Donald D. Stevenson | 523 |
| | Author Index | 539 |
| | Subject Index | 597 |
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