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Title Molecular microbiology of heavy metals / volume editors, Dietrich H. Nies, Simon Silver.
Imprint Berlin ; New York : Springer, 2007.

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Series Microbiology monographs, 1862-5576 ; 6
Microbiology monographs ; 6. 1862-5576
Subject Metal ions -- Metabolism.
Heavy metals -- Metabolism.
Metal ions -- Metabolic detoxification.
Molecular genetics.
Inactivation, Metabolic.
Bacteria -- metabolism.
Bacterial Proteins -- metabolism.
Cation Transport Proteins -- metabolism.
Metals, Heavy -- metabolism.
Alt Name Nies, Dietrich H.
Silver, S. (Simon)
Description 1 online resource (viii, 460 pages) : illustrations (some color).
polychrome rdacc
Bibliography Note Includes bibliographical references and index.
Summary All forms of life depend on a variety of heavy metal ions. Nearly one-third of all gene products require a metal ion for proper folding or function. However, even metals generally regarded as non-poisonous are toxic at higher concentrations, including the essential ones. Thus, sensitive regulation of metal uptake, storage, allocation and detoxification is needed to maintain cellular homeostasis of heavy metal ions. Molecular Microbiology of Heavy Metals includes chapters on allocation of metals in cells, metal transporter, storage and metalloregulatory proteins, cellular responses to metal ion stress, transcription of genes involved in metal ion homeostasis, uptake of essential metals, metal efflux and other detoxification mechanisms. Also discussed are metal bioreporters for the nanomolar range of concentration and tools to address the metallome. Chapters in the second part cover specific metals such as Fe, Mn, Cu, Ni, Co, Zn and Mo as key nutrient elements and Ag, As, Cd, Hg and Cr as toxic elements.
Contents Molecular Physiology of Metal-Microbe Interactions According to Mechanisms -- Understanding How Cells Allocate Metals -- Metalloregulators: Arbiters of Metal Sufficiency -- Transcriptomic Responses of Bacterial Cells to Sublethal Metal Ion Stress -- Bacterial Transition Metal Homeostasis -- Biosensing of Heavy Metals -- AGlossary of Microanalytical Tools to Assess the Metallome -- Molecular Physiology of Metal-Microbe Interactions According to Groups -- Acquisition of Iron by Bacteria -- New Transport Deals for Old Iron -- Manganese: Uptake, Biological Function, and Role in Virulence -- How Bacteria Handle Copper -- Microbial Physiology of Nickel and Cobalt -- Zinc, Cadmium, and Lead Resistance and Homeostasis -- Microbiology of the Toxic Noble Metal Silver -- Mercury Microbiology: Resistance Systems, Environmental Aspects, Methylation, and Human Health -- Arsenic Metabolism in Prokaryotic and Eukaryotic Microbes -- Reduction and Efflux of Chromate by Bacteria -- Molybdate and Tungstate: Uptake, Homeostasis, Cofactors, and Enzymes.
Note Print version record.
ISBN 9783540697718
3540697705 (Cloth)
9783540697701 (Cloth)
ISBN/ISSN 10.1007/978-3-540-69771-8
OCLC # 185027042
Link Springer e-books
Additional Format Print version: Molecular microbiology of heavy metals. Berlin ; New York : Springer, 2007 9783540697701 3540697705 (DLC) 2006940357 (OCoLC)85830246

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