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Author Furberg, Bengt.
Title Evaluating clinical research : all that glitters is not gold / Bengt D. Furberg and Curt D. Furberg.
Imprint New York : Springer Verlag, 2007.
Edition Second edition.

View online
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Author Furberg, Bengt.
Subject Clinical medicine -- Research.
Clinical trials.
Medicine -- Research.
Biomedical Research -- methods.
Clinical Trials as Topic.
Drug Evaluation.
Research Design.
Alt Name Furberg, Curt.
Description 1 online resource (161 pages) : illustrations, portraits
polychrome rdacc
Edition Second edition.
Bibliography Note Includes bibliographical references (pages 149-158) and index.
Contents What is the purpose of this book? -- Why is benefit-to-harm balance essential to treatment decisions? -- What are the strengths of randomized controlled clinical trials? -- What are the weaknesses of randomized controlled clinical trials? -- Do meta-analyses provide the ultimate truth? -- What are the strengths of observational studies? -- What are the weaknesses of observational studies? -- Were the scientific questions stated in advance? -- Were the treatment groups comparable initially? -- Why is blinding/masking so important? -- How is symptomatic improvement measured? -- Is it really possible to assess quality of life? -- What is the value of biologic markers in drug evaluation? -- How are adverse drug reactions measured? -- How representative are study subjects in clinical trials? -- What happened to the study subjects who disappeared from the analysis? -- How reliable are active-control trials? -- How informative are composite outcomes? -- Do changes in biologic markers predict clinical benefit? -- How trustworthy are the authors? -- Does publication in a reputable scientific journal guarantee quality? -- Is it necessary to be a biostatistician to interpret scientific data? -- Are all drugs of a class interchangeable? -- How much confidence can be placed on economic analysis? -- How should I handle the massive flow of information? -- How well is research translated into clinical care?
Summary "The objective of this book is to make its readers better informed and more critical consumers of clinical research by helping them recognize the strengths and the weaknesses of scientific publications. In doing so, the reader will be able to distinguish patient-important and methodologically sound studies from those having limitations in design, conduct and interpretation." "There are no prerequisites for reading this book. The text is basic and has no statistical formulas. Key take-home messages are listed at the end of each chapter. The large number of cartoons has two purposes: First, to make the text easier to read and generate a few laughs and, second, to underscore specific points, sometimes in a provocative way."--Jacket.
Note Print version record.
ISBN 9780387728995
9780387728988 (alk. paper)
0387728988 (alk. paper)
OCLC # 191450392
Additional Format Print version: Furberg, Bengt. Evaluating clinical research. 2nd ed. New York : Springer Verlag, 2007 9780387728988 0387728988 (DLC) 2007930204 (OCoLC)154711997

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