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Title Turning up the heat on pain : TRPV1 receptors in pain and inflammation / Annika B. Malmberg, Keith R. Bley, editors.
Imprint Basel ; Boston : Birkhauser Verlag, 2005.

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Series Progress in inflammation research
PIR (Series)
Subject Nociceptors.
Inflammation -- Mediators.
Receptors, Drug -- antagonists & inhibitors.
Receptors, Drug -- physiology.
Capsaicin -- analogs & derivatives.
Capsaicin -- pharmacology.
Inflammation -- drug therapy.
Pain -- drug therapy.
Alt Name Malmberg, Annika B., 1966-
Bley, Keith R.
Description 1 online resource (xii, 249 pages) : illustrations.
Bibliography Note Includes bibliographical references and index.
Contents Part I: Historical perspective on capsaicin and its receptor. Hot peppers, pain and analgesics / Janos Szolcsanyi -- Part II: Molecular and cellular properties of vanilloid receptors. Structural determinants of TRPV1 functionality / Makoto Tominaga ; TRPV1 distribution and regulation / Janet Winter -- Part III: Pharmacology and physiology of vanilloid receptors. Insights into TRPV1 pharmacology provided by non-capsaicin ligands / Peter M. Blumberg, Derek C. Braun, Noemi Kedei, Jozsef Lazar, Vladimir Pavlyukovets and Larry V. Pearce ; Endocannabinoids and vanilloid TRPV1 receptors / Ruth A. Ross ; Vanilloid receptor-mediated hyperalgesia and desensitization / Zoltan Sandor and Arpad Szallasi ; Capsaicin in human experimental pain models of skin, muscle and visceral sensitization / Lars Arendt-Nielsen and Ole K. Andersen -- Part IV: Vanilloid receptor involvement in disease states. TRPV1 in gut function, abdominal pain and functional bowel disorders / Peter Holzer ; TRPV1 in the airways / Maria G. Belvisi and Peter J. Barnes -- Part V: Therapeutic potential of vanilloid agonists and antagonists. TRPV1 agonist-based therapies: mechanism of action and clinical prospects / Keith R. Bley and Annika B. Malmberg ; TRPV1 agonist therapies in bladder diseases / Francisco Cruz, Carlos Silva and Paulo Dinis ; TRPV1 antagonists and chronic pain / Kenneth J. Valenzano, James D. Pomonis and Katharine Walker.
Summary Vanilloids mediate their effects by selective agonism of an ion channel, the vanilloid receptor 1 (TRPV1). TRPV1 is a ligand-gated, non-selective, cation channel preferentially expressed in small-diameter, primary afferent neurons, including nociceptive sensory nerves. In addition to be activated by capsaicin and related vanilloids, TRPV1 responds to heat and extracellular acidification, and will integrate simultaneous exposures to these stimuli. The aim of this book is to summarize recent insights in the role of TRPV1 in pain and inflammation, and to discuss how modulation of this receptor ma.
ISBN 3764370807 (alk. paper)
3764373792 (electronic bk.)
9783764373795 (electronic bk.)
6610413460 (electronic bk.)
9786610413461 (electronic bk.)
OCLC # 67615216
Link Springer e-books
Additional Format Print version: Turning up the heat on pain. Basel ; Boston : Birkhauser Verlag, 2005 3764370807 (DLC) 2005048122 (OCoLC)60651130

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