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LEADER 00000cam  22007094i 4500 
001    67615216 
003    OCoLC 
005    20181101050807.4 
006    m     o  d         
007    cr |n||||||||| 
008    050609s2005    sz a    ob    001 0 eng c 
010    2005048122 
019    133157659|a262681088|a401428245|a402416068|a607525963
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       |a1044602122|a1056329840|a1056344860|a1056371026
       |a1056398145 
020    3764370807|q(alk. paper) 
020    9783764370800 
020    3764373792|q(electronic bk.) 
020    9783764373795|q(electronic bk.) 
020    6610413460|q(electronic bk.) 
020    9786610413461|q(electronic bk.) 
035    (OCoLC)67615216|z(OCoLC)133157659|z(OCoLC)262681088
       |z(OCoLC)401428245|z(OCoLC)402416068|z(OCoLC)607525963
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       |z(OCoLC)1044602122|z(OCoLC)1056329840|z(OCoLC)1056344860
       |z(OCoLC)1056371026|z(OCoLC)1056398145 
037    978-3-7643-7080-0|bSpringer|nhttp://www.springerlink.com 
040    COO|beng|epn|erda|cCOO|dN$T|dYDXCP|dUAB|dOCLCQ|dIDEBK
       |dOCLCQ|dTUU|dOCLCQ|dGW5XE|dIAK|dMHW|dYNG|dEBLCP|dOCLCQ
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042    pcc 
049    MAIN 
050  4 QP451.4|b.T87 2005 
060  4 2005 M-648 
060  4 QV 38|bT955 2005 
072  7 MED|x057000|2bisacsh 
072  7 PSY|x020000|2bisacsh 
082 04 612.8/8|222 
245 00 Turning up the heat on pain :|bTRPV1 receptors in pain and
       inflammation /|cAnnika B. Malmberg, Keith R. Bley, 
       editors. 
264  1 Basel ;|aBoston :|bBirkhauser Verlag,|c2005. 
300    1 online resource (xii, 249 pages) :|billustrations. 
336    text|btxt|2rdacontent 
337    computer|bc|2rdamedia 
338    online resource|bcr|2rdacarrier 
347    text file|2rdaft|0http://rdaregistry.info/termList/
       fileType/1002 
490 1  Progress in inflammation research 
504    Includes bibliographical references and index. 
505 0  Part I: Historical perspective on capsaicin and its 
       receptor. Hot peppers, pain and analgesics / Janos 
       Szolcsanyi -- Part II: Molecular and cellular properties 
       of vanilloid receptors. Structural determinants of TRPV1 
       functionality / Makoto Tominaga ; TRPV1 distribution and 
       regulation / Janet Winter -- Part III: Pharmacology and 
       physiology of vanilloid receptors. Insights into TRPV1 
       pharmacology provided by non-capsaicin ligands / Peter M. 
       Blumberg, Derek C. Braun, Noemi Kedei, Jozsef Lazar, 
       Vladimir Pavlyukovets and Larry V. Pearce ; 
       Endocannabinoids and vanilloid TRPV1 receptors / Ruth A. 
       Ross ; Vanilloid receptor-mediated hyperalgesia and 
       desensitization / Zoltan Sandor and Arpad Szallasi ; 
       Capsaicin in human experimental pain models of skin, 
       muscle and visceral sensitization / Lars Arendt-Nielsen 
       and Ole K. Andersen -- Part IV: Vanilloid receptor 
       involvement in disease states. TRPV1 in gut function, 
       abdominal pain and functional bowel disorders / Peter 
       Holzer ; TRPV1 in the airways / Maria G. Belvisi and Peter
       J. Barnes -- Part V: Therapeutic potential of vanilloid 
       agonists and antagonists. TRPV1 agonist-based therapies: 
       mechanism of action and clinical prospects / Keith R. Bley
       and Annika B. Malmberg ; TRPV1 agonist therapies in 
       bladder diseases / Francisco Cruz, Carlos Silva and Paulo 
       Dinis ; TRPV1 antagonists and chronic pain / Kenneth J. 
       Valenzano, James D. Pomonis and Katharine Walker. 
520    Vanilloids mediate their effects by selective agonism of 
       an ion channel, the vanilloid receptor 1 (TRPV1). TRPV1 is
       a ligand-gated, non-selective, cation channel 
       preferentially expressed in small-diameter, primary 
       afferent neurons, including nociceptive sensory nerves. In
       addition to be activated by capsaicin and related 
       vanilloids, TRPV1 responds to heat and extracellular 
       acidification, and will integrate simultaneous exposures 
       to these stimuli. The aim of this book is to summarize 
       recent insights in the role of TRPV1 in pain and 
       inflammation, and to discuss how modulation of this 
       receptor ma. 
650  0 Nociceptors.|0http://id.loc.gov/authorities/subjects/
       sh85092154 
650  0 Pain.|0http://id.loc.gov/authorities/subjects/sh85096617 
650  0 Inflammation.|0http://id.loc.gov/authorities/subjects/
       sh85066108 
650  0 Inflammation|xMediators.|0http://id.loc.gov/authorities/
       subjects/sh85066109 
650 12 Receptors, Drug|xantagonists & inhibitors.|0https://
       id.nlm.nih.gov/mesh/D011955Q000037 
650 12 Receptors, Drug|xphysiology.|0https://id.nlm.nih.gov/mesh/
       D011955Q000502 
650 22 Capsaicin|xanalogs & derivatives.|0https://id.nlm.nih.gov/
       mesh/D002211Q000031 
650 22 Capsaicin|xpharmacology.|0https://id.nlm.nih.gov/mesh/
       D002211Q000494 
650 22 Inflammation|xdrug therapy.|0https://id.nlm.nih.gov/mesh/
       D007249Q000188 
650 22 Pain|xdrug therapy.|0https://id.nlm.nih.gov/mesh/
       D010146Q000188 
655  4 Electronic books. 
700 1  Malmberg, Annika B.,|d1966-|0http://id.loc.gov/authorities
       /names/n2001130603 
700 1  Bley, Keith R.|0http://id.loc.gov/authorities/names/
       n2005042449 
773 0  |tSpringer e-books 
776 08 |iPrint version:|tTurning up the heat on pain.|dBasel ; 
       Boston : Birkhauser Verlag, 2005|z3764370807|w(DLC)  
       2005048122|w(OCoLC)60651130 
830  0 PIR (Series)|0http://id.loc.gov/authorities/names/
       n98030914 
990    SpringerLink|bSpringer English/International eBooks 2005 -
       Full Set|c2018-10-31|yNew collection 
       springerlink.ebooks2005|5OH1 
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