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Title Checkpoint responses in cancer therapy / edited by Wei Dai.
Imprint Totowa, NJ : Humana Press, 2008.

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Series Cancer drug discovery and development
Cancer drug discovery and development.
Subject Antineoplastic agents.
Cell cycle -- Regulation.
Oncogenes -- genetics.
Cell Transformation, Neoplastic -- drug effects.
Cell Proliferation -- drug effects.
Gene Expression Regulation, Neoplastic.
Antineoplastic Agents -- pharmacology.
Neoplasms -- drug therapy.
Alt Name Dai, Wei, Ph. D.
Description 1 online resource (xiii, 314 pages) : illustrations.
polychrome rdacc
Bibliography Note Includes bibliographical references and index.
Contents RB-Pathway -- Targeting the p53/MDM2 Pathway for Cancer Therapy -- DNA Topoisomerases as Targets for the Chemotherapeutic Treatment of Cancer -- Targeting ATM/ATR in the DNA Damage Checkpoint -- Compounds that Abrogate the G2 Checkpoint -- CDK Inhibitors as Anticancer Agents -- CHFR as a Potential Anticancer Target -- Antimicrotubule Agents -- Kinesin Motor Inhibitors as Effective Anticancer Drugs -- Targeting the Spindle Checkpoint in Cancer Chemotherapy -- Antiproliferation Inhibitors Targeting Aurora Kinases -- Plks as Novel Targets for Cancer Drug Design -- Do Histone Deacetylase Inhibitors Target Cell Cycle Checkpoints that Monitor Heterochromatin Structure?
Summary Extensive research has uncovered a set of molecular surveillance mechanisms - commonly called "checkpoints"--Which tightly monitor cell-cycle processes. Today's anticancer drug development has identified many of these cell-cycle checkpoint molecules as effective targets. Research now promises to uncover a new generation of anticancer drugs with improved therapeutic indices based on their ability to target emerging checkpoint components. Checkpoint Responses in Cancer Therapy summarizes the advances made over the past 20 years, identifying components of cell-cycle checkpoints and their molecular regulation during checkpoint activation and validating the use of checkpoint proteins as targets for the development of anticancer drugs. This book's distinguished panel of authors takes a close look at topics ranging from the major molecular players affecting DNA synthesis and the response to DNA damage to advances made in the identification of chemical compounds capable of inhibiting individual mitotic kinases. Illuminating and authoritative, Checkpoint Responses in Cancer Therapy offers a critical summary of findings for researchers in the pharmaceutical and biotechnology industries and a valuable resource for academic scientists in cancer research and the study of cell-cycle regulation, signal transduction and apoptosis.
Note Print version record.
ISBN 9781597452748
9781588299307 (hbk.)
1588299309 (hbk.)
OCLC # 272309273
Additional Format Print version: Checkpoint responses in cancer therapy. Totowa, NJ : Humana Press, 2008 9781588299307 1588299309 (DLC) 2007940763 (OCoLC)244659248

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