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EBOOK
Author Selvarajoo, Kumar,
Title Immuno Systems Biology : a macroscopic approach for immune cell signaling / by Kumar Selvarajoo.
Imprint New York, NY : Springer New York : Imprint : Springer, 2013.

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LOCATION CALL # STATUS MESSAGE
 OHIOLINK SPRINGER EBOOKS    ONLINE  
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Series Systems Biology, 2191-222X ; 3
Systems Biology ; 3. 2191-222X
Subject Medicine.
Immunology.
Bioinformatics.
Biological models.
Cytology.
Immune System.
Immunity, Cellular.
Systems Biology.
Description 1 online resource (IX, 146 pages 69 illustrations, 61 illustrations in color.) : online resource.
Contents Preface -- Systems biology of population cell response -- Perturbation-response approach for biological network analysis -- Basics of the mammalian immune system -- Inferring novel features of the TLR4 pathways -- Signaling Flux Redistribution -- Investigating the TLR3 signaling dynamics -- Understanding TNFR1 signaling dynamics -- TRAIL signaling in cancer -- Stochasticity and variability: insights from single cell dynamics -- Investigating single cell stochasticity in TRAIL signaling -- The distinction between single cell and population dynamics -- Finding chaos in biology -- Concluding remarks -- Index.
Summary Technological advances of modern biology have generated high volumes of 'omics' data. The natural precedence has been to put the complex information together, so that it will lead to spectacular scientific discoveries and medical breakthroughs. In this light, tremendous efforts worldwide are reshaping biological research by integrating with information science. Despite the 'systems biology' efforts, for major illnesses, such as proinflammatory diseases and cancer, there is clear clinical evidence that even the most current therapies, at best, control transient response and subdue to the robust adaptability of the disease state. Hence, there is a need for system-levels understanding of bio-complexity. Kumar Selvarajoo brings attention to fundamental questions governing sophisticated behaviors of the mammalian immune system. To tackle some of the complex issues, the book introduces perturbation-response approach, using the law of physics (mass flow conservation), as a means to interpret the dynamic response of major proinflammatory pathways of the immune and cancer cells. Overall, the book provides an illustrated journey that explains biological cell signaling in simple terms.
Bibliography Note Includes bibliographical references and index.
ISBN 9781461476900
1461476909
1461474590
9781461474593
1306163129
9781306163125
ISBN/ISSN 10.1007/978-1-4614-7690-0
OCLC # 865495083
Additional Format Printed edition: 9781461474593