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Title Current topics in innate immunity II / John D. Lambris, George Hajishengallis, editors.
Imprint New York, NY : Springer, [2012]

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LOCATION CALL # STATUS MESSAGE
 OHIOLINK SPRINGER EBOOKS    ONLINE  
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Series Advances in experimental medicine and biology, 0065-2598 ; 946
Advances in experimental medicine and biology ; v. 946.
Subject Natural immunity.
Biological Phenomena.
Receptors, Immunologic.
Lymphocytes.
Microbiological Phenomena.
Immunity.
Leukocytes, Mononuclear.
Receptors, Cell Surface.
Immune System Phenomena.
Membrane Proteins.
Phenomena and Processes.
Leukocytes.
Proteins.
Immune System.
Blood Cells.
Amino Acids, Peptides, and Proteins.
Blood.
Hemic and Immune Systems.
Cells.
Anatomy.
Chemicals and Drugs.
Killer Cells, Natural.
Adaptive Immunity.
Receptors, Pattern Recognition.
Immunity, Innate.
Host-Pathogen Interactions.
Medicine
Immunology
Toxicology
Medical virology
Microbiology
Biomedicine
Infectious Diseases
Pharmacology/Toxicology
Alt Name Lambris, J. D. (John D.)
Hajishengallis, George.
Description 1 online resource (1 volume) : illustrations.
Bibliography Note Includes bibliographical references.
Summary Annotation Mounting evidence in the past decade indicates that innate immunity mediates functions above and beyond first-line defense against infection. It is now appreciated that innate immune mechanisms are critically involved in the development of adaptive immunity and, moreover, the regulation of diverse physiological and homeostatic processes. The latter explains why deregulation of innate immunity may lead to pathological disorders that are not necessarily or directly related to host defense. This Volume compiles the latest advances in this rapidly evolving field as presented by eminent scientists at the 7th International Aegean Conference on Innate Immunity in Rhodes, Greece. It includes topics related to the biology and function of Toll-like and other pattern-recognition receptors, complement and its crosstalk with other physiological systems, inflammatory mechanisms and diseases, natural killer cells, and the cooperative interplay between innate and adaptive immune cells. This book is an excellent source of information for researchers and clinicians with interests in immunology, host-microbe interactions, and infectious and inflammatory diseases.
Contents Pentraxins in humoral innate immunity -- galectins as pattern recognition receptors: structure, function, and evolution -- the role of innate immunity in trafficking of hematopoietic stem cells -- an emerging link between activation of complement cascade and chemotactic gradients of bioactive sphingolipids -- interaction of the microbiome with the innate immune response in chronic wounds -- keystone species and community service through manipulation of innate immunity -- a conserved host and pathogen site on immunoglobulins: structural and functional aspects -- advances in understanding the structure, function, and mechanism of the scin and efb families of staphylococcal immune evasion proteins -- granzyme b: a new crossroad of complement and apoptosis -- role of c3, c5 and anaphylatoxin receptors in acute lung injury and in sepsis -- complement mediated ocular angiogenesis -- platelets, complement, and contact activation: partners in inflammation and thrombosis -- nuclear factor-[kappa]b in immunity and inflammation: the treg and th17 connection -- function of act1 in il-17 family signaling and autoimmunity -- differential effect of inhibiting md-2 and cd14 on lps- versus whole e. coli bacteria-induced cytokine responses in human blood -- zebrafish: model for the study of inflammation and the innate immune response to infectious diseases -- monocyte-derived inflammatory dendritic cells in the granuloma during mycobacterial infection -- nk/dc crosstalk in anti-viral response -- innate-adaptive crosstalk: how dendritic cells shape immune responses in the cns -- nutritional immunity: homology modeling of nramp metal import.
Preface; Contents; List of Contributors; Pentraxins in Humoral Innate Immunity; 1 Introduction; 2 The Pentraxin Superfamily; 3 The Short Pentraxins in Innate Immunity; 4 The Long Pentraxin PTX3; 4.1 Gene Organization and Expression; 4.2 Protein Structure; 4.3 Interaction with Complement and Fcγ Receptors; 4.4 PTX3 in Pathogen Recognition and Inflammation; 4.5 Self versus Modified Self-Discrimination; 4.6 PTX3 Role in Tissue Remodelling; 4.7 Diagnostic and Prognostic Potential of PTX3 in Infectious Disorders; 5 Concluding Remarks; References.
Note English.
ISBN 9781461401063 (electronic bk.)
1461401062 (electronic bk.)
1461401054 (Trade Cloth)
1283351838
9781283351836
9781461401056 (Trade Cloth)
9781461401056
ISBN/ISSN 10.1007/978-1-4614-0106-3
OCLC # 757824509
Additional Format Print version: Current topics in innate immunity II. New York : Springer, 2012 (DLC) 2007926254