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LEADER 00000cam  2200625Ki 4500 
001    728100132 
003    OCoLC 
005    20181101051935.2 
006    m     o  d         
007    cr cn||||||||| 
008    110602s2011    gw a    o     001 0 eng d 
010    2011925543 
015    GBA937283|2bnb 
019    714645900|a985056111|a1005790407 
020    9783211990797|q(electronic bk.) 
020    3211990798|q(electronic bk.) 
020    |z9783211094273 
020    |z321109427X 
035    (OCoLC)728100132|z(OCoLC)714645900|z(OCoLC)985056111
       |z(OCoLC)1005790407 
037    978-3-211-09427-3|bSpringer|nhttp://www.springerlink.com 
040    GW5XE|beng|epn|erda|cGW5XE|dOCLCQ|dN$T|dOCLCQ|dOCLCF
       |dBEDGE|dCUS|dYDXCP|dW2U|dIDEBK|dOCLCQ|dVT2|dOCLCQ|dESU
       |dIOG|dOCLCA|dCEF|dU3W|dOCLCO|dAU@ 
049    MAIN 
050  4 QP624.74|b.M48 2011 
060 00 2011 G-092 
060 10 QU 131 
072  7 SCI|x029000|2bisacsh 
082 04 572.8645|222 
245 00 Metallointercalators :|bsynthesis and techniques to probe 
       their interactions with biomolecules /|cJanice Aldrich-
       Wright, Editor. 
264  1 Wien ;|aNew York :|bSpringer-Verlag/Wien,|c2011. 
300    1 online resource (xxviii, 427 pages) :|billustrations 
336    text|btxt|2rdacontent 
337    computer|bc|2rdamedia 
338    online resource|bcr|2rdacarrier 
340    |gpolychrome|2rdacc|0http://rdaregistry.info/termList/
       RDAColourContent/1003 
347    text file|2rdaft|0http://rdaregistry.info/termList/
       fileType/1002 
504    Includes bibliographical references and index. 
505 0  Introduction -- Synthesis:Platinum Intercalating 
       Complexes; Binuclear Platinum Complexes;Binuclear 
       Ruthenium and Platinum Intercalating Complexes; Sequence 
       Selective Intercalating Complexes; Targeting and Improving
       Transport, Cucurbit[n]uril, Cylcodextrin and Dendrimers --
       Techniques to Probe Interactions with Biomolecules:
       Introduction to NMR; DNA-NMR; PGSE-NMR; DNA ESI-MS; 
       Investigating Binding Interactions using Linear Dichromism
       and Circular Dichromism; Flourescence Spectroscopy; 
       Confocal Microscopy; Implementation of synchotron X-ray 
       microscopy for investigations of the cellular uptake and 
       cellular metabolism of metallointercalators; Biomolecular 
       Helical Structure; Viscosity, TGA and Dialysis; 
       Microarrays; Cytotoxicity-Cell lines; Antibacterical 
       activity; Animal testing. 
520    A comprehensive treatment of the characterisation 
       techniques used in investigating inorganic and organic 
       molecules that interact with biomolecules is presented to 
       the reader in a clear fashion. The work consists of two 
       parts: (i) synthetic aspects of metallointercalators along
       with targeting and improving transport and (ii) the 
       various techniques that are used for probing their 
       interactions, such as; DNA-NMR, PGSE-NMR, DNA ESI-MS, 
       Linear and Circular Dichroism, Fluorescence Spectroscopy, 
       Confocal Microscopy, Viscosity, TGA and dialysis, 
       Microarrays, biological analysis. Chapters are devoted to 
       the synthesis and the techniques used to study the 
       interactions of inorganic complexes with biomolecules. 
       Considerably detailed examples are used to help illustrate
       the application of these techniques. This book is a useful
       resource for an array of inorganic and organic advanced 
       undergraduate and graduate courses and for researchers in 
       drug discovery. 
588 0  Print version record. 
650  0 DNA-ligand interactions.|0http://id.loc.gov/authorities/
       subjects/sh89006999 
650  0 Clathrate compounds.|0http://id.loc.gov/authorities/
       subjects/sh85026824 
650  0 Transition metal complexes.|0http://id.loc.gov/authorities
       /subjects/sh88005203 
650  0 Genetic regulation.|0http://id.loc.gov/authorities/
       subjects/sh85053870 
650  0 Biomolecules.|0http://id.loc.gov/authorities/subjects/
       sh85014249 
650 12 Intercalating Agents|xchemistry.|0https://id.nlm.nih.gov/
       mesh/D007364Q000737 
650 12 Organometallic Compounds|xchemistry.|0https://
       id.nlm.nih.gov/mesh/D009942Q000737 
650 22 Magnetic Resonance Spectroscopy.|0https://id.nlm.nih.gov/
       mesh/D009682 
655  4 Electronic books. 
700 1  Aldrich-Wright, Janice.|0http://id.loc.gov/authorities/
       names/no2012037065 
776 08 |iPrint version:|tMetallointercalators.|dSpringer Verlag 
       Wien 2009|z9783211094273|w(OCoLC)310401044 
990    SpringerLink|bSpringer English/International eBooks 2011 -
       Full Set|c2018-10-31|yNew collection 
       springerlink.ebooks2011|5OH1 
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