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Title Laron syndrome - from man to mouse : lessons from clinical and experimental experience / Zvi Laron, J. Kopchick (editors).
Imprint Berlin ; New York : Springer, 2011.

LOCATION CALL # STATUS MESSAGE
 OHIOLINK SPRINGER EBOOKS    ONLINE  
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LOCATION CALL # STATUS MESSAGE
 OHIOLINK SPRINGER EBOOKS    ONLINE  
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Subject Laron dwarfism.
Laron dwarfism -- Treatment.
Phenotype.
Laron Syndrome.
Laron Syndrome -- therapy.
Laron Syndrome.
Insulin-Like Growth Factor I.
Mice.
Models, Animal.
Alt Name Laron, Zvi.
Kopchick, John J.
Description 1 online resource (xiv, 531 pages) : illustrations (some color)
polychrome rdacc
Bibliography Note Includes bibliographical references and index.
Contents History of the Israeli cohort of Laron syndrome patients (1958-2009) -- Early investigations: characterizations of the circulating growth hormone -- Clinical evidence of growth hormone resistance in patients with Laron syndrome -- Diagnosis of Laron syndrome -- Genetic aspects -- Clinical evaluation -- Perinatal development in Laron syndrome -- Linear grown pattern of untreated Laron syndrome patients -- Head shape, size, and growth of untreated patients with Laron syndrome -- Sexual development in patients with Laron syndrome -- Sex hormone binding proteins and sex hormones in untreated and IGF-I treated patients with Laron syndrome -- The adipose tissue in patients with Laron syndrome -- Investigations to determine the cause of obesity in patients with Laron syndrome -- Nonalcoholic fatty liver disease (Nafld) in patients with Laron syndrome -- Serum lipids in patients with Laron syndrome -- Adiponectin and leptin in Laron syndrome -- Muscle force and endurance in untreated adult and IGF-I treated children with Laron syndrome -- Bone mineral density in untreated and IGF-I or alendronate-treated patients with Laron syndrome -- Muscle-bone relationship in patients with Laron syndrome.
Imaging findings in Laron syndrome -- Ocular findings in Laron syndrome -- Hearing in patients with Laron syndrome -- The teeth in patients with Laron syndrome -- Hair, skin, and nails in patients with Laron syndrome -- Hand, foot, and organ size and growth in untreated and IFG-I treated patients with Laron syndrome -- Lifelong serum growth hormone levels in patients with Laron syndrome -- IGF-I binding proteins in Laron syndrome -- Serum prolactin in untreated and IGF-I treated patients with Laron syndrome -- Thyroid hormones in untreated and IGF-I treated patients with Laron syndrome -- Insulin secretion and carbohydrate metabolism in patients with Laron syndrome: from hypoglycemia to diabetes mellitus -- Liver enzymes in patients with Laron syndrome -- The hematopoietic system in patients with Laron syndrome -- Cardiovascular aspects in Laron syndrome patients -- Kidney functions in untreated and IGF-I treated patients with Laron syndrome -- Sleep and sleep disorders in patients with Laron syndrome -- Neurological aspects in Laron syndrome -- Orthopedic problems in Laron syndrome -- Psychological aspects in patients with Laron syndrome.
Adjustment and rehabilitation problems of children, adolescents, and adults with Laron syndrome -- Laron syndrome patients with congenital IGF-I deficiency seem protected from malignant diseases -- Lifespan and mortality of patients with Laron syndrome -- IGF-I treatment of patients with Laron syndrome -- IGF-I stimulation of head growth in patients with Laron syndrome -- Effects of long-term administration of IGF-I on the adipose tissue and carbohydrate metabolism in children with Laron syndrome -- Comparison of the growth promoting response of IGF-I in children with Laron syndrome with that of hGH in children with isolated GH deficiency -- IGF-I treatment of adult patients with Laron syndrome -- Adverse effects encountered during IGF-I treatment of patients with Laron syndrome -- Summary of the clinical history: the Laron syndrome clock -- The Laron mouse -- Role of GH/IGF-I deficiency in aging -- Body composition, adipose tissue, and energy balance -- Metabolism and metabolic regulation -- Skeletal muscle -- Cardiac function in GHR-/-mice -- Bone -- GHR knockout and the CNS -- Cancer -- Reproduction -- Conclusions and future studies.
Summary Laron syndrome (LS), or primary growth hormone (GH) insensitivity, was first described in 1966. Since then, many patients worldwide have been diagnosed with LS, which involves defects in the GH receptor that cause combined congenital deficiency of GH and IGF-I activities. In this comprehensive book the authors draw upon 50 years of multidisciplinary clinical and investigative follow-up of the large Israeli cohort of LS patients. The genetic basis of the syndrome is fully considered, and all aspects of the pathophysiology of IGF-I deficiency are described. Data derived from the recently generat.
Note Print version record.
ISBN 9783642111839 (electronic bk.)
3642111831 (electronic bk.)
9783642111822
3642111823
ISBN/ISSN 10.1007/978-3-642-11183-9
OCLC # 694574574
Additional Format Print version: Laron syndrome - from man to mouse. Berlin ; New York : Springer, 2011 9783642111822 (OCoLC)645706617



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