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LEADER 00000cam  2200901Ia 4500 
001    318545556 
003    OCoLC 
005    20200911141904.4 
006    m     o  d         
007    cr cn||||||||| 
008    090415s2009    it a    ob    001 0 eng d 
010    2008936505 
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024 8  9786612005251 
024 7  10.1007/978-88-470-1095-6|2doi 
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       |z(OCoLC)1162692032 
037    978-88-470-1094-9|bSpringer|nhttp://www.springerlink.com 
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049    MAIN 
050  4 RC262|b.M85 2009 
060  4 2008 M-908 
060  4 QZ 200|bM9615 2009 
072  7 MED|x062000|2bisacsh 
072  7 HEA|x039030|2bisacsh 
072  7 MJCL|2bicssc 
082 04 616.994|222 
245 00 Multiple primary malignancies /|c[edited by] Andrea Renda.
260    Milan ;|aNew York :|bSpringer,|c2009. 
300    1 online resource (xxii, 287 pages) :|billustrations 
336    text|btxt|2rdacontent 
337    computer|bc|2rdamedia 
338    online resource|bcr|2rdacarrier 
347    text file|bPDF|2rda 
490 1  Updates in surgery 
504    Includes bibliographical references and index. 
505 0  Introduction -- Nosography -- Epidemiology -- 
       Carcinogenesis -- Iatrogenic multiple tumours (chemo- and 
       radio-inducted) -- Immunodeficiency and MMT -- MMT and HPV
       infections: Pathology Dept's experience about MMT -- 
       Hereditary codified syndromes -- Multifocal tumours and 
       multiple tumours -- Hereditary and familial ovarian breast
       cancer -- Hereditary syndromes: the experience of the 
       University of Siena -- Sporadic colo-rectal tumours and 
       MMT -- MMT not-codified syndromes -- Laboratory for MMT at
       -risk patients -- Role of advanced endoscopy to identify 
       synchronous and metachronous tumours -- Imaging technique 
       for synchronous tumours -- Hereditary syndromes: DNA-
       guided therapeutic implications -- Role of chemoprevention
       -- Conclusion. 
520    Two to three decades ago, multiple primary malignancies 
       (MPM) were considered to be simply a clinical curiosity, 
       with sporadic reports, mostly single case descriptions, 
       found in the literature. While in the last few years, 
       analyses of larger series have been published, the number 
       of cases has still been relatively small and most of the 
       reports have addressed a single type of primary tumor and 
       its associations. With the improved prognosis and survival
       of cancer patients, MPM is becoming increasingly prevalent
       in this population, necessitating a better understanding 
       of the characteristics and associations of the 
       malignancies involved. Thus, as a prerequisite, a 
       universal definition and an internationally accepted 
       classification system, based on chronological, 
       pathological, clinical, and other parameters, are needed. 
       Moreover, much remains to be learned about the etiology of
       MPM, whether genetic, iatrogenic, or environmental. 
       Several of the hereditary syndromes, such as familial 
       adenomatous polyposis, hereditary non-polyposis colorectal
       cancer, hereditary breast-ovarian cancer, and multiple 
       endocrine neoplasia, are already well-known and their 
       characteristics in relation to MPM must be kept in mind. 
       Nonetheless, along with these syndromes, there are 
       sporadic and apparently casual associations between 
       primary neoplasms that can involve almost any part of the 
       body. This volume points out the clinical aspects of MPM 
       and discusses the diagnostic and therapeutic problems that
       are encountered in treating these patients. "DNA-guided" 
       surgery, currently confined to the treatment of patients 
       with hereditary syndromes, will, along with other novel 
       treatment strategies, no doubt play an increasingly 
       greater role in the therapy of MPM. This work presents 
       state-of-the-art information about MPM that is aimed at a 
       broad range of medical specialists, including surgeons, 
       endoscopists, oncologists, and geneticists, . The goal is 
       to improve our understanding of this group of diseases as 
       well the treatment of these patients. 
546    English. 
588 0  Print version record. 
650  0 Tumors. 
650  0 Cancer. 
650  7 MEDICAL|xOncology.|2bisacsh 
650  7 HEALTH & FITNESS|xDiseases|xCancer.|2bisacsh 
650 07 Cancer.|2cct 
650 07 Neoplasms, Multiple Primary|xetiology.|2cct 
650 07 Neoplasms, Multiple Primary|xdiagnosis.|2cct 
650 07 Neoplasms, Multiple Primary|xtherapy.|2cct 
650 07 Tumors.|2cct 
650  7 Cancer.|2fast|0(OCoLC)fst00845317 
650  7 Tumors.|2fast|0(OCoLC)fst01158759 
650 12 Neoplasms, Multiple Primary|xetiology. 
650 22 Neoplasms, Multiple Primary|xdiagnosis. 
650 22 Neoplasms, Multiple Primary|xtherapy. 
700 1  Renda, Andrea,|cProf. 
776 08 |iPrint version:|tMultiple primary malignancies.|dMilan ; 
       New York : Springer, 2009|z9788847010949|z8847010942
       |w(DLC)  2008936505|w(OCoLC)293334932 
830  0 Updates in surgery. 
990    Rittenhouse Books, Inc.|bRittenhouse R2 Digital Library 
       (Patron Driven Acquisitions)|c2020-09-11|yCustom text 
       change|5MHT 
990    Rittenhouse Books, Inc.|bRittenhouse R2 Digital Library 
       (Patron Driven Acquisitions)|c2020-09-03|yNew collection 
       rittenhouse.ebookspda|5MHT 
990    SpringerLink|bSpringer English/International eBooks 2009 -
       Full Set|c2018-11-23|yMaster record variable field(s) 
       change: 650|5OH1 
990    SpringerLink|bSpringer English/International eBooks 2009 -
       Full Set|c2018-11-16|yMaster record variable field(s) 
       change: 650|5OH1 
990    SpringerLink|bSpringer English/International eBooks 2009 -
       Full Set|c2018-10-31|yNew collection 
       springerlink.ebooks2009|5OH1 
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