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Title Advances in biology and therapy of multiple myeloma. Volume 2, Translational and clinical research / edited by Nikhil C. Munshi, Kenneth C. Anderson.
Imprint New York ; London : Springer, 2013.

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Subject Multiple myeloma.
Multiple myeloma -- Treatment.
Multiple Myeloma.
Multiple Myloma -- Treatment.
Alt Name Munshi, Nikhil C.
Anderson, Kenneth C.
Add Title Translational and clinical research
Description 1 online resource
polychrome rdacc
Contents Myeloma Immune and Antibody Targets -- T Cell Responses in Myeloma / Ross Brown, P. Joy Ho, John Gibson, Douglas Joshua -- Novel Antigenic Targets for Immunotherapy in Myeloma / Qing Yi -- Antibody-Based Therapies in Multiple Myeloma / Yu-Tzu Tai -- Defining Multiple Myeloma as a Target for DNA Vaccines / Surinder S. Sahota, Natalia Savelyeva, Debora Joseph-Pietras, Niklas Zojer -- Harnessing Allogeneic Immunity for Anti-myeloma Response / Roberto Bellucci, Edwin P. Alyea -- Dendritic Cells and Peptide-Based Vaccine In Multiple Myeloma / Jooeun Bae, R.H. Prabhala, Nikhil C. Munshi -- New Agents -- Novel Proteasome Inhibitors / Robert Z. Orlowski -- Newer IMiDs / Abhishek Singla, Shaji Kumar. -- Novel Agents in Multiple Myeloma / Anuj Mahindra, Jacob Laubach, Constantine Mitsiades, Paul Richardson -- Early Combination Studies in Multiple Myeloma / Alessandra Larocca, Antonio Palumbo -- The Effect of Novel Anti-myeloma Agents on Bone Metabolism / Evangelos Terpos.
T cell responses in myeloma -- Novel antigenic targets for immunotherapy in myeloma -- Antibody-based therapies in Multiple Myeloma -- Defining multiple myeloma as a target for DNA gene fusion vaccines -- Harnessing allogeneic immunity for anti-myeloma response -- Dendritic cell and peptide-based vaccination in myeloma -- New Proteasome inhibitors -- Newer Imids -- New agents in myeloma -- Early Combination Studies in MM -- The effect of novel antimyeloma agents on bone metabolism -- Index.\
Summary Despite the advances in conventional, and novel agent and high dose chemotherapy, multiple myeloma remains incurable. In order to overcome resistance to current therapies and improve patient outcome, novel biologically-based treatment approaches are being developed. Current translational research in multiple myeloma focusing on the development of molecularly-based novel targeted single-agent and combination therapies has great promise to achieve high frequency and durable responses in the majority of patients. This volume will focus on biology of multiple myeloma, especially on oncogenomic changes, cell signaling pathways and intermediate molecules that are being investigated for development of novel therapies. The book will present newer developments, providing an emphasis on basic science, as well as its significant clinical impact.
Bibliography Note cludes bibliographical references.
Note Print version record.
ISBN 9781461452607 (electronic bk.)
1461452600 (electronic bk.)
1461452597 (print)
9781461452591 (print)
ISBN/ISSN 10.1007/978-1-4614-5260-7
OCLC # 821823520
Additional Format Print version: Advances in biology and therapy of multiple myeloma. Volume 2, Translational and clinical research. New York ; London : Springer, 2012 9781461452591 (OCoLC)817270653

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