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LEADER 00000cam  2200877Ii 4500 
001    1008962916 
003    OCoLC 
005    20200417040025.6 
006    m     o  d         
007    cr cnu---unuuu 
008    171102s2017    sz      ob    001 0 eng d 
019    1008977054|a1013490496|a1013908411|a1017895215|a1026954097
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020    9783319579856|q(electronic bk.) 
020    3319579851|q(electronic bk.) 
020    |z9783319579832 
020    |z3319579835 
024 7  10.1007/978-3-319-57985-6|2doi 
024 8  10.1007/978-3-319-57 
035    (OCoLC)1008962916|z(OCoLC)1008977054|z(OCoLC)1013490496
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       |z(OCoLC)1086452907|z(OCoLC)1090455920|z(OCoLC)1105169254 
037    com.springer.onix.9783319579856|bSpringer Nature 
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049    MAIN 
050  4 RC280.U8 
060  4 2018 C-249 
060  4 WP 458 
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072  7 MED|x022000|2bisacsh 
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082 04 616.99/466|223 
245 00 Precision molecular pathology of uterine cancer /|cMichael
       T. Deavers, Donna M. Coffey, editors. 
264  1 Cham :|bSpringer,|c2017. 
300    1 online resource. 
336    text|btxt|2rdacontent 
337    computer|bc|2rdamedia 
338    online resource|bcr|2rdacarrier 
340    |gpolychrome|2rdacc|0http://rdaregistry.info/termList/
       RDAColourContent/1003 
347    text file|bPDF|2rda 
490 1  Molecular pathology library. 
504    Includes bibliographical references and index. 
505 0  Contents -- Contributors -- Introduction -- 1 Endometrial 
       Carcinoma: Precursor Lesions and Molecular Profiles -- 
       Introduction -- Endometrioid Carcinoma (Type 1) -- 
       Precursor Lesions -- Uterine Serous Carcinoma (Type 2) -- 
       Precursor Lesions -- Molecular Signature -- Molecular 
       Alterations in Endometrioid Carcinoma -- Molecular 
       Alterations in Serous Carcinoma -- Genomic 
       Characterization of USC -- Conclusion -- References -- 
       Endometrial Carcinoma -- 2 Classification of Endometrial 
       Carcinoma -- A Putative Pathogenetic Model for Endometrial
       Carcinoma 
505 8  Histopathologic ClassificationEndometrioid Adenocarcinoma 
       -- Mucinous Carcinoma -- Serous Carcinoma -- Clear Cell 
       Carcinoma -- Mixed Carcinoma -- Undifferentiated Carcinoma
       -- Neuroendocrine Tumors -- Staging of Endometrial 
       Carcinoma -- Prognostic Factors -- Hereditary Endometrial 
       Carcinoma -- References -- 3 Immunohistochemical Markers 
       in Endometrial Carcinoma -- Endometrial Carcinoma Versus 
       ExtramAllerian Primaries -- Endometrial Carcinoma Versus 
       Other MAllerian Primaries -- Subtyping of Endometrial 
       Carcinoma 
505 8  Endometrial Carcinoma and Lynch SyndromeAcknowledgements -
       - References -- 4 Molecular Pathology of Endometrioid 
       Adenocarcinoma -- Introduction -- PI3K/AKT Pathway -- PTEN
       -- PIK3CA -- PIK3R1 and PIK3R2 -- ARID1A -- KRAS -- CTNNB1
       -- TP53 -- Microsatellite Instability -- POLE -- The 
       Cancer Genome Atlas -- Acknowledgement -- References -- 5 
       The Molecular Pathology of Serous Endometrial Cancer -- 
       Introduction -- Introduction to the Molecular Pathology of
       SEC -- TP53 Aberrations in SEC -- PI3K Pathway Aberrations
       in SEC 
505 8  PI3K Pathway Aberrations as Therapeutic Targets in SECHER2
       (ERBB2) Aberrations in SEC -- I#x97;I#x95;R2 as a 
       Therapeutic Target in SEC -- FBXW7 Aberrations in SEC -- 
       PPP2R1A Mutations in SEC -- CHD4 Mutations in SEC -- SPOP 
       Mutations in SEC -- TAF1 Mutations in SEC -- Novel 
       Clinical Trial Designs -- Summary and Conclusion -- 
       References -- 6 Uterine Clear Cell Carcinoma -- 
       Introduction -- Histopathologic Features -- 
       Immunophenotypic Features -- Genetic Features -- 
       Biological Function of Immunohistochemical and Genetic 
       Markers -- HNF-1I² -- Napsin A 
505 8  Bax and Bcl-2TP53/p53 -- ARID1A/BAF250a -- PPP2R1A -- 
       PIK3CA -- PTEN -- Precursor Lesion and Oncogenesis -- 
       Similarity and Differences of Molecular Features of 
       Endometrial and Ovarian Clear Cell Carcinoma -- Conclusion
       and Future Directions -- References -- 7 Mucinous 
       Adenocarcinoma of the Endometrium -- Clinical Features -- 
       Histopathologic Features -- Immunohistochemical Profile --
       Differential Diagnosis -- Papillary Mucinous Metaplasia, a
       Possible Precursor of Mucinous Endometrial Adenocarcinoma 
       -- Pyloric/Gastric Metaplasia of the Endometrium 
520    This text provides a comprehensive review for practicing 
       pathologists to understand the molecular biology, 
       diagnostics, and predictive markers and implications for 
       therapy of uterine cancer. While molecular based 
       therapeutic strategies for uterine cancer are not as well 
       developed as for some other organ sites, these are the 
       most common gynecologic malignancies and there have been 
       many important recent developments that are discussed in 
       this volume. Comprehensive chapters address essential 
       information about endometrial carcinoma, uterine 
       mesenchymal tumors, and cervical carcinoma and include the
       pathogenesis of carcinoma and discuss molecular based 
       classification, biomarkers, therapy, prevention, and 
       hereditary cancers of the uterus. Precision Molecular 
       Pathology of Uterine Cancer is a unique and one of a kind 
       resource for practicing pathologists, pathologists in 
       training and gynecologists. 
588 0  Online resource; title from PDF title page (EBSCO, viewed 
       November 3, 2017). 
650  0 Uterus|xCancer.|0http://id.loc.gov/authorities/subjects/
       sh85141610 
650 12 Uterine Neoplasms|xpathology.|0https://id.nlm.nih.gov/mesh
       /D014594Q000473 
650 22 Molecular Diagnostic Techniques.|0https://id.nlm.nih.gov/
       mesh/D025202 
650 22 Precision Medicine.|0https://id.nlm.nih.gov/mesh/D057285 
650 22 Uterine Neoplasms|xgenetics.|0https://id.nlm.nih.gov/mesh/
       D014594Q000235 
700 1  Deavers, Michael T.,|0http://id.loc.gov/authorities/names/
       n2009181762|eeditor. 
700 1  Coffey, Donna M.,|0http://id.loc.gov/authorities/names/
       n2012182829|eeditor. 
776 08 |iPrint version:|tPrecision molecular pathology of uterine
       cancer.|dCham : Springer, 2017|z9783319579832|z3319579835
       |w(OCoLC)982651633. 
830  0 Molecular pathology library series.|0http://id.loc.gov/
       authorities/names/n2008181238 
990    SpringerLink|bSpringer English/International eBooks 2017 -
       Full Set|c2020-04-17|yMaster record variable field(s) 
       change: 505|5OH1 
990    SpringerLink|bSpringer English/International eBooks 2017 -
       Full Set|c2020-01-24|yMaster record variable field(s) 
       change: 505|5OH1 
990    SpringerLink|bSpringer English/International eBooks 2017 -
       Full Set|c2020-01-17|yMaster record variable field(s) 
       change: 505|5OH1 
990    SpringerLink|bSpringer English/International eBooks 2017 -
       Full Set|c2018-11-30|yMaster record variable field(s) 
       change: 650|5OH1 
990    SpringerLink|bSpringer English/International eBooks 2017 -
       Full Set|c2018-10-31|yNew collection 
       springerlink.ebooks2017|5OH1 
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