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Title Replicating vaccines : a new generation / Philip R. Dormitzer, Christian W. Mandl, Rino Rappuoli, (editors).
Imprint Basel : Springer, 2011.

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Series Birkhauser advances in infectious diseases
Birkhäuser advances in infectious diseases.
Subject Vaccines -- Research.
Communicable diseases -- Prevention.
Vaccines, Attenuated.
Vaccination -- methods.
Vaccination -- trends.
Alt Name Dormitzer, Philip R.
Mandl, Christian W.
Rappuoli, Rino.
Description 1 online resource (xiii, 447 pages) : illustrations.
polychrome rdacc
Bibliography Note Includes bibliographical references and index.
Contents pt. 1. Today's live attenuated vaccines -- pt. 2. Genetically attenuated micro-organisms as vaccines -- pt. 3. Manipulating host-pathogen interactions to make vaccines -- pt. 4. New types of replicating vaccines.
Summary Technological advances, together with a better understanding of the molecular biology of infectious microorganisms, are creating exciting possibilities for a new generation of replicating vaccines. Historically, live vaccines have been either directly derived from a natural source or attenuated by empirical approaches using serial passages and host cell adaptation. Currently, we are witnessing a quantum leap in our technological capabilities to specifically modify the genetic make-up of viruses and bacteria, making it possible to generate improved live vaccines and to develop completely new types of replicating vaccines, such as vectored vaccines, single-round infectious vaccines and replicon vaccines. This book highlights some of the most exciting recent developments towards a new generation of replicating vaccines.
Note Print version record.
ISBN 9783034602778 (electronic bk.)
3034602774 (electronic bk.)
9783034602761 (hardcover ; alk. paper)
OCLC # 694146689
Additional Format Print version: Replicating vaccines. Basel : Springer, 2011 (DLC) 2010938606

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