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Title Structural virology / Mavis Agbandje-McKenna [and others], editors.
Imprint Cambridge : Royal Society of Chemistry, [2010]
©2011

Series RSC Biomolecular Sciences ; 21
RSC biomolecular sciences ; 21.
Subject Viruses -- Morphology.
Molecular virology.
Organisms.
Viral Structural Proteins.
Microbiological Phenomena.
Phenomena and Processes.
Viral Proteins.
Proteins.
Amino Acids, Peptides, and Proteins.
Chemicals and Drugs.
Nucleocapsid Proteins.
Viruses.
Virus Physiological Phenomena.
Alt Name Agbandje-McKenna, Mavis.
Description 1 online resource (299 pages).
Contents Introduction: Principles of Virus Structure Section 1Methodologies for Structural Analysis of Viruses Production and Purification of Viruses for Structural Studies Microscopic (Confocal) Analysis of Viral Entry and Infection Cryo-electron Microscopy of Virus Infection -- Tomography and Asymmetric Structure Determination Cryo-electron Microscopy of Viruses -- 3D of Virus Capsids X-ray Crystallography of Virus Capsids Structural Studies of Viral Proteins Probing Viral Capsid Structures in Solution Section 2Structure to Function Correlation for Viruses Evolution of Viral Capsid Structures -- the Three Domains of Life Mechanisms of Virus Capsid Assembly Mechanisms of Genome Packaging Attachment and Viral entry -- Receptor Recognition in Viral Pathogenesis Attachment and Entry -- Viral Cell Fusion Virus Antibody Recognition Section 3Therapeutic Strategies Based on Viral Structures Development of anti-HIV drugs Design of Influenza Vaccines and Antiviral Agents Engineering Viral Capsids as Nano Tools Viral Vectors for Gene Delivery
Summary Over the last ten years, much effort has been devoted to improving the biophysical techniques used in the study of viruses. This has resulted in the visualization of these large macromolecular assemblages at atomic level, thus providing the platform for functional interpretation and therapeutic design. Structural Virology covers a wide range of topics and is split into three sections. The first discusses the vast biophysical methodologies used in structural virology, including sample production and purification, confocal microscopy, mass spectrometry, negative-stain and cryo-electron microscop.
Note Online resource; title from title screen (viewed on June 15, 2010).
ISBN 9781849732239 (electronic bk.)
184973223X (electronic bk.)
ISBN/ISSN 10.1039/9781849732239
OCLC # 642693299