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Title International textbook of diabetes mellitus / editors-in-chief Ralph A. DeFronzo, Ele Ferrannini, Paul Zimmet, K. George M.M. Alberti.
Imprint Chichester, West Sussex : John Wiley & Sons Ltd., 2015.
Edition Fourth edition.

View online
View online
Subject Diabetes.
Diabetes Mellitus.
Alt Name DeFronzo, Ralph A.,
Ferrannini, Eleuterio,
Alberti, K. G. M. M. (Kurt George Matthew Mayer),
Zimmet, Paul,
Alternate Title Preceded by: International textbook of diabetes mellitus. 3rd ed.
Description 1 online resource
Edition Fourth edition.
Note Revised edition of: International textbook of diabetes mellitus / editors-in-chief, Ralph A. DeFronzo [and others]. 3rd ed. 2004.
Bibliography Note Includes bibliographical references and index.
Contents Section I. Epidemiology . Classification of diabetes mellitus and other categories of glucose intolerance -- Epidemiology and risk factors for type 1 diabetes mellitus -- Epidemiology and geography of type 2 diabetes mellitus -- Section II. Physiology of pancreatic function. Development and maintenance of the islet [beta] cell -- Pancreatic morphology in normal and diabetic states -- Insulin gene expression and biosynthesis -- [beta]-Cell biology of insulin secretion -- Normal [beta]-cell function -- Neuropeptides and islet hormone secretion -- Biosynthesis, secretion, and action of glucagon -- Incretin physiology in health and disease -- Section III. Normal physiology of insulin action. Mechanisms of insulin signal transduction -- Regulation of glucose metabolism in liver -- Insulin actions in vivo: glucose metabolism -- Measuring insulin action in vivo -- Protein metabolism in health and diabetes -- Lipid and lipoprotein metabolism, hypolipidemic agents, and therapeutic goals -- Metabolomics: applications in type 2 diabetes mellitus and insulin resistance -- Section IV. NAFLD, NASH and non-traditional associations with diabetes. Pathogenesis of nonalcoholic fatty liver disease (NAFLD) -- Treatment of nonalcoholic fatty liver disease (NAFLD) and nonalcoholic steatohepatitis (NASH) -- Type 2 diabetes and cancer -- Diabetes and sleep apnea -- Section V. Pathogenesis. The insulin resistance syndrome -- [beta]-Cell mass and function in human type 2 diabetes -- Pathogenesis of type 2 diabetes mellitus -- The genetics of type 2 diabetes -- Glucose toxicity -- Monogenic disorders of the [beta] cell -- Immunopathogenesis of type 1 diabetes in Western society -- Molecular genetics of type 1 diabetes -- Section VI. Obesity. The relationship between obesity and type 2 diabetes -- the role of gut factors. The role of energy metabolism in the regulation of energy balance -- Treatment of obesity: lifestyle and pharmacotherapy -- Treatment of obesity: bariatric surgery -- Animal models of obesity and type 2 diabetes -- The role of the hypothalamus in the maintenance of energy balance and peripheral glucose control -- Section VII. Clinical trial evidence in diabetes. Prevention of type 1 diabetes -- Prevention of type 2 diabetes -- Prevention of diabetic microvascular complications -- Section VIII. Management of diabetes: diet, exercise and drugs. Dietary management of diabetes mellitus in Europe and North America -- Exercise -- Sulfonylureas and meglitinides: insights into physiology and translational clinical utility -- Metformin and other biguanides: pharmacology and therapeutic usage -- PPAR agonists in the treatment of diabetes -- [alpha]-Glucosidase inhibitors -- Combination therapy in type 2 diabetes mellitus -- New drugs for the treatment of diabetes mellitus -- Incretin-based therapies -- Insulin pumps -- Innovative therapies in diabetes: colesevelam and bromocriptine -- Section IX. Management of diabetes: monitoring and other interventions. Implantable pumps and artificial and bio-artificial pancreas system -- Pancreas and islet transplantation -- Hypoglycemia and other complications of insulin therapy -- Diabetic ketoacidosis and hyperosmolar state -- Section X. Management of diabetes: glucose and lipid monitoring, specific subgroups. Type 2 diabetes in obese adolescents: pathophysiology and treatment -- Diabetes in pregnancy -- Aging and diabetes mellitus -- Psychological problems and management of patients with diabetes mellitus -- Glycated hemoglobin, serum proteins, and other markers as tools for monitoring -- Section XI. Complications of diabetes: general and microvasular. Pathogenesis of diabetic microvascular complications -- Diabetic retinopathy and other ocular complications -- Diabetic nephropathy -- Pathology of human diabetic neuropathy -- Autonomic neuropathy -- Connective tissue disorders in diabetes -- The diabetic foot -- Erectile dysfunction in diabetes mellitus -- Periodontal disease and diabetes mellitus -- Section XII. Complications of diabetes: macrovascular -- Epidemiology of macrovascular disease and hypertension in diabetes mellitus -- Atherogenesis, coronary heart disease and insulin resistance syndrome in diabetes -- Endothelial function and metabolic syndrome -- Hemostatic abnormalities in diabetes mellitus -- Clinical features and treatment of coronary heart disease in diabetes -- Arterial hypertension in diabetes: etiology and treatment -- Peripheral vascular and cerebrovascular disease in diabetes mellitus -- Section XIII. Diabetes and public health. The diabetes challenge: from human and social rights to the empowerment of people with diabetes -- The economics of diabetes care: a global perspective.
Summary "The International Textbook of Diabetes Mellitus has been a successful, well-respected medical textbook for almost 20 years, over 3 editions. Encyclopaedic and international in scope, the textbook covers all aspects of diabetes ensuring a truly multidisciplinary and global approach. Sections covered include epidemiology, diagnosis, pathogenesis, management and complications of diabetes and public health issues worldwide. It incorporates a vast amount of new data regarding the scientific understanding and clinical management of this disease, with each new edition always reflecting the substantial advances in the field. Whereas other diabetes textbooks are primarily clinical with less focus on the basic science behind diabetes, ITDM's primary philosophy has always been to comprehensively cover the basic science of metabolism, linking this closely to the pathophysiology and clinical aspects of the disease. Edited by four world-famous diabetes specialists, the book is divided into 13 sections, each section edited by a section editor of major international prominence. As well as covering all aspects of diabetes, from epidemiology and pathophysiology to the management of the condition and the complications that arise, this fourth edition also includes two new sections on NAFLD, NASH and non-traditional associations with diabetes, and clinical trial evidence in diabetes. This fourth edition of an internationally recognised textbook will once again provide all those involved in diabetes research and development, as well as diabetes specialists with the most comprehensive scientific reference book on diabetes available"--Publisher's description.
Note Online resource; title from electronic title page (Wiley Online Library, viewed September 7, 2017).
ISBN 9781118387658 (electronic book)
1118387651 (electronic book)
9781118387672 (ePub)
1118387678 (ePub)
9781118387689 (Adobe PDF)
1118387686 (Adobe PDF)
9780470658611 (cloth)
0470658614 (cloth)
ISBN/ISSN 10.1002/9781118387658
Publisher # EB00607353 Recorded Books
OCLC # 891427845
Additional Format Print version: International textbook of diabetes mellitus. Fourth edition. Chichester, West Sussex ; Hoboken, NJ : John Wiley & Sons Inc., 2015 9780470658611 (DLC) 2014037412 (OCoLC)891354125

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