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Title Microarrays in diagnostics and biomarker development : current and future applications / Bertrand Jordan, editor.
Imprint Heidelberg ; New York : Springer, 2012.

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Subject DNA microarrays.
Protein microarrays.
Alt Name Jordan, Bertrand.
Description 1 online resource (viii, 240 pages)
polychrome rdacc http://rdaregistry.info/termList/RDAColourContent/1003
Bibliography Note Includes bibliographical references and index.
Contents Part 1. DNA Arrays -- DNA Arrays in Many Guises / Bertrand Jordan -- Expression Profiling for Diagnostics / Bertrand Jordan -- Genotype Characterisation for Diagnostics / Bertrand Jordan -- Array-CGH and SNP-Arrays, the New Karyotype / Karoly Szuhai -- The Microarray Paradigm and Its Various Implementations / Bertrand Jordan -- Part 2. Protein (Antigen & Antibody) and Peptide Arrays -- Protein Microarrays and Their Potential Clinical Applications in the Era of Personalized Medicine / Hong Zhang and Steven Pelech -- Peptide Arrays / Hong Zhang, Steven Pelech, Rob Ruijtenbeek, Thomas Felgenhauer and Ralf Bischoff, et al. -- Slow Off-Rate Modified Aptamer Arrays for Biomarker Discovery and Diagnostic Applications / Jeffrey J. Walker, Edward N. Brody and Larry Gold -- Part 3. Other types of arrays -- Tissue Microarrays for Translational Research / Ronald Simon and Martina Mirlacher -- Recent and Future Developments of Microarrays: Miniaturization and Lab-on-Chip Approaches / Inbal Tsarfati-BarAd and Levi A. Gheber -- Part 4. Data analysis, commercial and regulatory aspects -- Analysis of Array Data and Clinical Validation of Array-Based Assays / Benjamin Haibe-Kains and John Quackenbush -- Challenges in the Commercialization of Array-Based Tests / Justin Petrone -- Genes, Microarrays, and Patents / Justin Petrone.
Summary Microarray technology has made strong progress over the past decade, and there have also been significant changes in application areas, from nucleic acids to proteomics and from research to clinical applications. This book provides a comprehensive overview of microarrays in diagnostics and biomarker development, covering DNA, peptide, protein and tissue arrays. The focus is on entities that are in actual clinical use, or quite close, and on recent developments, such as peptide and aptamer arrays. A further topic is the miniaturisation towards nanoarrays, which is expected to have great potential in clinical applications. Relevant issues of bioinformatics and statistical analysis of array data are discussed in detail, as well as the barriers to the commercialisation of array-based tests and the vexing IP issues involved. Thus, the book should be very useful tor active array users as well as to newcomers seeking to make the best choice between different technologies.
ISBN 9783642282034 (electronic bk.)
3642282032 (electronic bk.)
9783642282027 (alk. paper)
3642282024 (alk. paper)
OCLC # 792930407
Additional Format Print version: Microarrays in diagnostics and biomarker development. Heidelberg ; New York : Springer, 2012 9783642282027 (DLC) 2012936972 (OCoLC)773670836


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