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LEADER 00000cam  2200589Ii 4500 
001    950459481 
003    OCoLC 
005    20181123054800.5 
006    m     o  d         
007    cr cnu|||unuuu 
008    160524s2016    sz a    ob    000 0 eng d 
019    951222113|a961851569|a964884852|a1005758104 
020    9783319305677|q(electronic bk.) 
020    3319305670|q(electronic bk.) 
020    3319305654 
020    9783319305653 
020    |z9783319305653|q(print) 
035    (OCoLC)950459481|z(OCoLC)951222113|z(OCoLC)961851569
040    N$T|beng|erda|epn|cN$T|dGW5XE|dYDXCP|dIDEBK|dOCLCF|dAZU
049    MAIN 
050  4 QL966 
060  4 W1|bAD433K v.220 2016 
060  4 WJ 834 
072  7 SCI|x056000|2bisacsh 
082 04 571.8/451|223 
245 00 Sperm acrosome biogenesis and function during 
       fertilization /|cMariano G. Buffone, editor. 
264  1 Switzerland :|bSpringer,|c2016. 
300    1 online resource (vii, 172 pages) :|billustrations (some 
336    text|btxt|2rdacontent 
337    computer|bc|2rdamedia 
338    online resource|bcr|2rdacarrier 
340    |gpolychrome|2rdacc|0
347    text file|2rdaft|0
490 1  Advances in anatomy, embryology and cell biology,|x0301-
       5556 ;|v220 
504    Includes bibliographical references at the end of each 
505 0  Preface -- The acrosome reaction: a historical perspective
       -- The acrosomal matrix -- Role of ion channels in the 
       sperm acrosome reaction -- The molecules of sperm 
       exocytosis -- Sperm capacitation and acrosome reaction in 
       mammalian sperm -- Lipid regulation of acrosome exocytosis
       -- Role of actin cytoskeleton during mammalian sperm 
       acrosomal exocytosis -- Site of mammalian sperm acrosome 
520    Over the last decades, acrosomal exocytosis (also called 
       the "acrosome reaction") has been recognized as playing an
       essential role in fertilization. Secretion of this granule
       is an absolute requirement for physiological 
       fertilization. In recent years, the study of mammalian 
       acrosomal exocytosis has yielded some major advances that 
       challenge the long-held, general paradigms in the field. 
       Principally, the idea that sperm must be acrosome-intact 
       to bind to the zona pellucida of unfertilized eggs, based 
       largely on in vitro fertilization studies of mouse oocytes
       denuded of the cumulus oophorus, has been overturned by 
       experiments using state-of-the-art imaging of cumulus-
       intact oocytes and fertilization experiments where eggs 
       were reinseminated by acrosome-reacted sperm recovered 
       from the perivitelline space of zygotes. From a molecular 
       point of view, acrosome exocytosis is a synchronized and 
       tightly regulated process mediated by molecular mechanisms
       that are homologous to those reported in neuroendocrinal 
       cell secretions. The authors provide a broader perspective,
       focusing on a limited number of important topics that are 
       essential for understanding the molecular mechanisms 
       governing this step in the fertilization process. They 
       also discuss molecular aspects such as the signaling 
       pathways leading to exocytosis, including the 
       participation of ion channels, lipids, the fusion 
       machinery proteins and the actin cytoskeleton as well as 
       cellular aspects such as the site of acrosomal exocytosis 
       and the use of gene-manipulated animals to study this 
588 0  Online resource; title from PDF title page (SpringerLink, 
       viewed May 26, 2016). 
650  0 Acrosome reaction.|0
650 12 Acrosome|xphysiology.|0
650 22 Exocytosis|xphysiology.|0
650 22 Fertilization|xphysiology.|0
655  4 Electronic books. 
700 1  Buffone, Mariano G.,|0
776 08 |iPrint version:|aBuffone, Mariano G.|tSperm Acrosome 
       Biogenesis and Function During Fertilization.|dCham : 
       Springer International Publishing, 2016|z9783319305653 
830  0 Advances in anatomy, embryology, and cell biology ;|0http:
       //|vv. 220. 
990    SpringerLink|bSpringer English/International eBooks 2016 -
       Full Set|c2018-11-23|yMaster record variable field(s) 
       change: 650, 776|5OH1 
990    SpringerLink|bSpringer English/International eBooks 2016 -
       Full Set|c2018-10-31|yNew collection 
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