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Author Reichenbach, Andreas, 1950-
Title Muller cells in the healthy and diseased retina / by Andreas Reichenbach, Andreas Bringmann.
Imprint New York ; London : Springer, 2010.

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Author Reichenbach, Andreas, 1950-
Subject Retina -- Cytology.
Retina -- cytology.
Neuroglia -- pathology.
Neuroglia -- physiology.
Retinal Diseases -- physiopathology.
Alt Name Bringmann, Andreas.
Description 1 online resource (xiv, 417 pages) : illustrations (some color)
Bibliography Note Includes bibliographical references and index.
Contents Introduction -- Basic properties of Muller cells -- Muller cell gliosis -- Muller cells in the healthy retina -- Retinal Development -- Muller cells as 'light cables' -- Soft Muller cells as shock absorbers and axon paths -- 'Metabolic symbiosis' -- Neurotransmitter recycling -- Retinal K+ homeostasis -- Retinal water homeostasis -- Other interactions -- Muller cells in the diseased retina -- Retinal detachment -- Diabetic retinopathy -- Macular edema -- Proliferative retinopathies -- Ischemia-reperfusion -- Hepatic retinopathy -- Retinoschisis -- Retinitis pigmentosa and support of neuronal survival -- Future directions -- Index.
Summary Muller cells make up just 0.005% of the cells in our central nervous system. They do not belong to the more esteemed family of neuronal cells but to the glia, a family of cells that until recently were seen as mere filling material between the neurons. Now, however, all that has changed. Sharing the insights of more than a quarter century of research into Muller cells, Drs. Andreas Reichenbach and Andreas Bringmann of Leipzig University make a compelling case for the central role Muller cells play. Everyone agrees that the eye is a very special and versatile sense organ, yet it has turned out in recent years that Muller cells are peculiar and multipotent glial cells. In the retina of most vertebrates and even of many mammals, Muller cells are the only type of (macro- ) glial cells; thus, they are responsible for a wealth of neuron-supportive functions that, in the brain, rely upon a division of labour among astrocytes, oligodendrocytes, and ependymal cells. Even beyond such a role in the central nervous system as "model glia", Muller cells are adapted to several exciting roles in support of vision. They deliver the light stimuli to the photoreceptor cells in the inverted vertebrate retina, aid the processing of visual information, and are responsible for the homeostatic maintenance of the retinal extracellular milieu. In Muller Cells in the Healthy and Diseased Retina, aimed not just at neurobiologists but at anyone concerned with retinal degeneration, every angle of Muller cells is covered, from an introduction to their basic properties, through their roles as 'light cables' and 'shock absorbers', to the part they play in diseases and disorders of the eye. Once these have all been covered in detail, the authors move on to discuss the future direction of research into these small but potent cellular phenomena. About the Authors Dr. Andreas Reichenbach was born in 1950 in Leipzig, Germany. He studied medicine and specialized as a physiologist, working on the mammalian retina. Since 1984, he has focused his efforts - and those of a growing number of fellows in his team - on Muller cell research. He has held a professorship at Leipzig University since 1994. After studying biology, Dr. Andreas Bringmann (* 1960) worked in the field of systemic neurophysiology until he was inspired in 1996 by Andreas Reichenbach to research the most interesting cell, the Muller cell. He is now in the Department of Ophthalmology of the University of Leipzig where he is the head of the Basic Research Laboratory.
Note English.
Print version record.
ISBN 9781441916723
9781441916716 (hbk.)
1441916717 (hbk.)
ISBN/ISSN 10.1007/978-1-4419-1672-3
OCLC # 663096718
Additional Format Print version: Reichenbach, Andreas, 1950- Muller cells in the healthy and diseased retina. New York ; London : Springer, 2010 9781441916716 1441916717 (DLC) 2009943587 (OCoLC)449852922

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