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Title Eicosanoids, aspirin, and asthma / edited by Andrzej Szczeklik, Ryszard J. Gryglewski, John R. Vane.
Imprint New York, N.Y. : M. Dekker, [1998]
©1998

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Series Lung biology in health and disease ; v. 114
Lung biology in health and disease ; v. 114.
Subject Asthma -- Pathophysiology.
Asthma -- Etiology.
Eicosanoids -- Pathophysiology.
Aspirin -- Side effects.
Aspirin -- Immunology.
Asthma -- chemically induced.
Asthma -- metabolism.
Aspirin -- adverse effects.
Cyclooxygenase Inhibitors -- adverse effects.
Eicosanoids -- metabolism.
Alt Name Szczeklik, Andrzej.
Gryglewski, Ryszard.
Vane, John R.
NetLibrary, Inc.
Description xxvii, 605 pages : illustrations ; 24 cm.
Bibliography Note Includes bibliographical references and indexes.
Reproduction Electronic reproduction. Boulder, Colo. : NetLibrary, 2001. Available via World Wide Web. Access may be limited to NetLibrary affiliated libraries.
ISBN 058534504X (electronic bk.) : $195.00
0824701461 (alk. paper)
OCLC # 47011880
Additional Format Original (DLC) 98005319 (OCoLC)38312001.
Table of Contents
 Introduction / Claude Lenfant 
 Preface 
 Contributors 
1Mechanism of Action of Antiinflammatory Drugs / John R. Vane, Regina M. Botting1
2Pathways of Arachidonate Metabolism / John C. McGiff, Michael Balazy25
3Cytochromes P450 and Arachidonic Acid Metabolism / Michael Balazy, John C. McGiff45
4Mechanisms of Isoprostane Biosynthesis in Humans / Paola Patrignani, Roberto Padovano, Maria Gina Sciulli [et al.]77
5Intracellular Localization of Eicosanoid-Forming Enzymes / Thomas G. Brock, Marc Peters-Golden91
6Cyclooxygenase-2 Expression in Airway Cells / Peter J. Barnes, Maria G. Belvisi, Robert Newton [et al.]111
7Cyclooxygenase Gene Expression and Regulation / Kenneth Kun-yu Wu129
8NSAID-Induced Apoptosis: A New Therapeutic Activity of Competitive Cyclooxygenase Inhibitors? / Daniel L. Simmons145
9The Three-Dimensional Structure of Cyclooxygenases / Daniel Picot161
10The Role of 5-Lipoxygenase Products in a Mouse Model of Allergic Airway Inflammation Charles G. [et al.] / Colin D. Funk, Xin-Sheng Chen187
11Genetic Influences on Asthma / William O. C. M. Cookson201
12Intrinsic Asthma / Leonardo M. Fabbri, Gaetano Caramori, Bianca Beghe [et al.]215
13Viral Infection and Asthma: The Modulatory Role of Nitric Oxide on Prostaglandin H Synthase / Gert Folkerts, Frans P. Nijkamp231
14The Pharmacology of Prostaglandin E[subscript 2]: Actions in Human Diseases Involving the Mast Cell / John A. Oates, John J. Murray, David D. Hagaman [et al.]253
15Eicosanoids in the Pathogenesis of Exercise- and Allergen-Induced Asthma / Paul M. O'Byrne259
16Endotoxin-Induced Acute Respiratory Distress Syndrome in Nitric Oxide-Deficient Rats / Pawel P. Wolkow, Ewa Janowska, Joanna B. Bartus [et al.]273
17Eicosanoid Regulation by Glucocorticoids in Asthma / Ryszard Dworski283
18Mechanisms of Aspirin-Induced Asthma / Andrzej Szczeklik299
19Leukotrienes in Aspirin-Sensitive Asthma / S. M. Shuaib Nasser, Tak H. Lee317
20Mast Cell and Eosinophil Responses After Indomethacin in Asthmatics Tolerant and Intolerant to Aspirin / Esther L. Langmack, Sally E. Wenzel337
21Aspects of Mechanisms in Aspirin-Intolerant Asthma / Barbro Dahlen351
22Aspirin-Intolerant Asthma: New Insights from Bronchial Mucosal Biopsies / Anthony P. Sampson371
23Pharmacological Intervention in Generation of Leukotrienes by Eosinophils / Klaus F. Rabe, Gordon Dent391
24Airway Ion Transport Mechanisms and Aspirin in Asthma / Sebastiano Bianco, Maria Robuschi, Andriano Vaghi [et al.]419
25Role of Autoantibodies Against Endothelial Cells in Severe Asthma / Philippe Lassalle, Michel Joseph, Andre-Bernard Tonnel439
26Clinical Course of Aspirin-Induced Asthma: Results of AIANE / Ewa Nizankowska, Mariusz Duplaga, Grazyna Bochenek [et al.]451
27Nasal Polyposis / Niels Mygind, Ronald Dahl, Per L. Larsen [et al.]473
28The Nose in Aspirin-Sensitive Asthma / Cesar Picado, Joaquim Mullol493
29The Role of Glucocorticoids in the Modulation of Eicosanoid Metabolism in Asthma / Isabelle Vachier, Pascal Chanez, Claude Chavis [et al.]507
30Desensitization in Aspirin-Induced Asthma / Donald D. Stevenson523
 Author Index539
 Subject Index597