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Title Therapeutic Fc Fusion Proteins / edited by Steven M. Chamow [and others].
Imprint Weinheim : Wiley-Blackwell, 2014.

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Subject Peptide drugs.
Proteins -- Synthesis.
Recombinant Fusion Proteins -- therapeutic use.
Immunoglobulin Fc Fragments -- therapeutic use.
Recombinant Fusion Proteins -- pharmacology.
Immunoglobulin Fc Fragments -- pharmacology.
Alt Name Chamow, Steven Mark.
Description 1 online resource
Contents Introduction: Antibody Structure and Function / Arvind Rajpal, Pavel Strop, Yik Andy Yeung, Javier Chaparro-Riggers, Jaume Pons -- Methods of Production for Fc-Fusion Proteins. Fc-Fusion Protein Expression Technology / Jody D Berry, Catherine Yang, Janean Fisher, Ella Mendoza, Shanique Young, Dwayne Stupack -- Cell Culture-Based Production / Yao-Ming Huang, Rashmi Kshirsagar, Barbara Woppmann, Thomas Ryll -- Downstream Processing of Fc-Fusion Proteins / Abhinav A Shukla, Uwe Gottschalk -- Formulation, Drug Product, and Delivery: Considerations for Fc-Fusion Proteins / Wenjin Cao, Deirdre Murphy Piedmonte, Margaret Speed Ricci, Ping Y Yeh -- Quality by Design Applied to a Fc-Fusion Protein: A Case Study / Alex Eon-Duval, Ralf Gleixner, Pascal Valax, Miroslav Soos, Benjamin Neunstoecklin, Massimo Morbidelli, Herve Broly -- Analytical Methods Used to Characterize Fc-Fusion Proteins / Esohe Idusogie, Michael Mulkerrin -- Case Studies of Therapeutic Fc-Fusion Proteins. Introduction to Therapeutic Fc-Fusion Proteins / Jody D Berry -- Alefacept / Deborah A Farson -- Etanercept / Johanna Grossman, Steven M Chamow -- Abatacept and Belatacept / Robert J Peach -- Aflibercept / Angela L Linderholm, Steven M Chamow -- Recombinant Factor VIII- and Factor IX-Fc Fusions / Robert T Peters, Judy R Berlfein.
Note Includes index.
Print version record.
Bibliography Note Includes bibliographical references and index.
Summary Annotation Edited by three pioneers in the field - each with longstanding experience in the biotech industry - and a skilled scientific writer, this is the first book to cover every step in the development and production of immunoglobulin Fc-fusion proteins as therapeutics for human disease: from choosing the right molecular design, to pre-clinical characterization of the purified product, through to batch optimization and quality control for large-scale cGMP production. The whole of the second part is devoted to case studies of Fc-fusion proteins that are now commercially successful products. In this section, the authors, several of whom were personally involved in clinical development of the products themselves, detail the product's background and give insight into issues that were faced and how these issues were overcome during clinical development. This section also includes a chapter on promising new developments for the future. An invaluable resource for professionals already working on Fc-fusion proteins and an excellent and thorough introduction for physicians, researchers, and students entering the field.
ISBN 9783527675272 (oBook)
3527675272 (oBook)
9783527675296 (ePDF)
3527675299 (ePDF)
1306256178 (electronic bk.)
9781306256179 (electronic bk.)
9783527333172 (print)
3527333177 (print)
9783527675289 (epub)
9783527675302 (mobi)
OCLC # 866839740
Additional Format Print version: 9781306256179

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