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Title Near infrared-emitting nanoparticles for biomedical applications / Antonio Benayas, Eva Hemmer, Guosong Hong, Daniel Jaque, editors.
Imprint Cham : Springer, 2020.

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Subject Biomedical engineering.
Alt Name Benayas, Antonio.
Hemmer, Eva.
Hong, Guosong.
Jaque, D. (Daniel)
Description 1 online resource (391 pages)
Note Description based upon print version of record.
6.3.3 Photoluminescence Modulation by Environment
Contents Intro -- Preface and Summary -- Acknowledgements -- Contents -- 1 Optical Properties of Tissues in the Near Infrared: Their Relevance for Optical Bioimaging -- 1.1 Optical Properties of Tissues: Physical Origin and Statistical Approach -- 1.1.1 Basic Interactions Between Light and Matter -- 1.2 Light Propagation in Biological Tissues -- 1.3 Properties of Light in the Near Infrared -- 1.3.1 Blood -- 1.3.2 Water -- 1.3.3 Skin -- 1.3.4 Tissue Autofluorescence -- 1.4 Imaging in the II Near Infrared Window -- 1.5 Consequences of Near Infrared Light Propagation in Image Quality and Resolution
2.4.3 Intra-Operative Parathyroid Gland Identification -- 2.4.4 Imaging Atherosclerotic Plaque in Coronary Artery Disease -- 2.5 Conclusion and Future Perspectives -- References -- 3 Surface Modification of Near Infrared-Emitting Nanoparticles for Biomedical Applications -- 3.1 Introduction -- 3.2 Strategies for Surface Modification -- 3.3 Conclusion and Challenges in Surface Modification -- References -- 4 Rare Earth-Doped Nanoparticles for Advanced In Vivo Near Infrared Imaging -- 4.1 Introduction -- 4.2 NIR Emissions from RENPs -- 4.2.1 NIR Upconversion Luminescence
4.2.2 NIR Downshifting Luminescence -- 4.3 In Vivo NIR Imaging Using RENPs -- 4.3.1 Bioimaging Using NIR UCL -- 4.3.2 Bioimaging Using NIR-II Downshifting Luminescence -- 4.4 Time-Gated Luminescence Imaging -- 4.4.1 Principle of Time-Gated Imaging -- 4.4.2 Time-Gated Imaging in NIR-II Window -- 4.4.3 Multiplexing Imaging with Tunable Lifetimes -- 4.5 Conclusions -- References -- 5 Recent Advances in Development of NIR-II Fluorescent Agents -- 5.1 NIR-II Fluorophores with High Fluorescence Quantum Yields -- 5.2 NIR-II Fluorophores with Long Emission Wavelengths
5.3 Favorable Pharmacokinetics and Biocompatibility -- 5.4 Outlook -- References -- 6 Near Infrared Spectral Imaging of Carbon Nanotubesfor Biomedicine -- 6.1 Introduction -- 6.2 Optophysical Properties of Single-Walled Carbon Nanotubes -- 6.2.1 Intrinsic Bandgap Photoluminescence -- 6.2.2 Isolation of Single-Nanotube Chiralities -- 6.2.3 Inherent Multiplicity of Nanotube Structures -- 6.2.4 Biocompatibility -- 6.3 Photoluminescent SWCNTs as Imaging and Sensing Agents -- 6.3.1 Structural Properties of Linear SWCNTs -- 6.3.2 Advantageous Optical Properties
Bibliography Note References -- 2 NIR Autofluorescence: Molecular Origins and Emerging Clinical Applications -- 2.1 Introduction -- 2.2 NIR Autofluorescence as a Problem -- 2.3 NIR Autofluorescence Sources -- 2.3.1 Autofluorescence in the Visible -- 2.3.2 In Vivo Autofluorescence in the NIR: Plant Sources -- 2.3.3 In Vivo Skin Autofluorescence in the NIR -- 2.3.4 Other Sources of In Vivo NIR Autofluorescence -- 2.4 NIR Autofluorescence as a Solution: Applications -- 2.4.1 Surgical Guidance and Diagnostics in Cancer -- 2.4.2 Monitoring Ophthalmological Diseases
Summary This book analyzes and evaluates the growing field of light-emitting nanoprobes as contrast agents for in vivo imaging and sensing. It is a comprehensive resource that critically analyzes the state of the art in an interdisciplinary manner, with a special focus on the shift of emission wavelengths into the near-infrared (NIR) spectral region (ranging from 0.7 to 2 microns), which has greatly contributed to the latest advances in biomedical imaging and sensing. This book discusses merits of different contrast agents at nanoscale, and how their unique chemical and structural properties lead to the emission and interaction of light within the NIR window. Both the NIR-emitting materials and various surface modification strategies governing their interactions with the biological system at the "nano" level are discussed. Furthermore, different experimental techniques and protocols for NIR-light-based in vivo imaging and sensing are addressed to shed light on further understanding of the advantages and limitations of each category of these nanoprobes. Assembles the state of the art heretofore appearing in scientific literature into a comprehensive, multi-perspective guidebook on near infrared-emitting nanomaterials in an assortment of biomedical applications; Explains the physical, chemical, and biological phenomena underlying near infrared-emitting nanomaterials for biomedical applications; Presents conceptual and experimental approaches surrounding a unique spectral range of light emission from nanosized contrast agents, while offering a clear explanation of basic and general phenomena regarding the interaction between light and biological tissues, such as absorption, scattering and autofluorescence.
ISBN 9783030320362 (electronic bk.)
3030320367 (electronic bk.)
9783030320355 (print)
ISBN/ISSN 10.1007/978-3-030-32
OCLC # 1152060507
Additional Format Print version: Benayas, Antonio Near Infrared-Emitting Nanoparticles for Biomedical Applications Cham : Springer International Publishing AG,c2020 9783030320355.

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