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Title Efficiency in natural product total synthesis / edited by Pei-Qiang Huang, Zhu-Jun Yao, Richard P. Hsung.
Imprint Hoboken, NJ : Wiley, 2018.
Edition First edition.

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Subject Natural products -- Synthesis.
Organic compounds -- Synthesis.
Alt Name Huang, Peiqiang, 1962-
Yao, Zhu-Jun,
Hsung, Richard P.,
Description 1 online resource
Edition First edition.
Bibliography Note Includes bibliographical references and index.
Note Print version record and CIP data provided by publisher.
Contents 1.2.4 The C-H Bond Functionalization Strategy1.2.5 The Building-Block Strategy; 1.2.6 The Collective Synthesis Strategy; 1.2.7 The Oligomerization Tactic; 1.3 The Expansion of the Field: Chemical Biology/Chemical Genetics; 1.3.1 Diversity-Oriented Synthesis (DOS); 1.3.2 Function-Oriented Synthesis (FOS); 1.3.3 Biology-Oriented Synthesis (BIOS); 1.3.4 Lead-Oriented Synthesis (LOS); 1.4 Addressing the Threats that Humans May Face in the Near Future; 1.4.1 A.G. Myers' Endeavor; 1.4.2 D.L. Boger's Endeavor; Acknowledgements; References.
Intro; Title Page; Copyright Page; Contents; Contributors; Foreword; Preface; Introduction; 1 The Golden Age of the Total Synthesis of Natural Products: The Era as a Dominant Field; 2 1991-2000: A Contrasting Decade; 3 Total Synthesis in the Twenty-First Century; 4 The Challenges of the Efficiency in the Total Synthesis of Natural Products; 5 The Renaissance of Natural Products as Drug Candidates; 6 Recent Recognition of the Contribution of Natural Product-Based Drugs to Society; Acknowledgements; References; Chapter 1 Principles for Synthetic Efficiency and Expansion of the Field.
1.1 Concepts for Efficiency in the Total Synthesis of Natural Products1.1.1 Ideal Synthesis; 1.1.2 Selectivity; 1.1.3 Green Synthesis; 1.1.4 Atom Economy; 1.1.5 E Factors; 1.1.6 Step Economy; 1.1.7 Pot Economy and PASE (Pot, Atom, and Step Economy); 1.1.8 Redox Economy; 1.1.9 Protecting-Group-Free Synthesis; 1.1.10 Multicomponent Reactions and One-Pot Reactions; 1.1.11 Scalability; 1.1.12 Convergent Synthesis; 1.2 Biomimetic Synthesis; 1.2.1 Basic Logic of Biosynthesis; 1.2.2 Tandem, Cascade, and Domino Reactions -- One-Pot Reactions; 1.2.3 Site and Stereoselective Reactions.
Chapter 2 Selected Procedure-Economical Enantioselective Total Syntheses of Natural Products2.1 One-Step/One-Pot Enantioselective Total Synthesis of Natural Products/Drugs; 2.1.1 Robinson's One-Step Synthesis of Tropinone; 2.1.2 Hayashi's One-Pot Synthesis of (+)-ABT-341; 2.2 Two-Step/Two-Pot Enantioselective Total Synthesis of Natural Products; 2.2.1 Hayashi's Two-Pot Synthesis of (−)-Oseltamivir; 2.2.2 Ma's Two-Pot Synthesis of (−)-Oseltamivir; 2.2.3 Li's Two-Step Chemoenzymatic Total Synthesis of Aszonalenin; 2.2.4 Ishikawa's Two-Step Total Syntheses of (+)-WIN 64821 and (+)-Naseseazine B
2.3 Three-Step/Three-Pot Enantioselective Total Synthesis of Natural Products2.3.1 Carreira's Three-Step Asymmetric Total Syntheses of (+)-Aszonalenin and (−)-Brevicompanine B; 2.3.2 Husson's Three-Step Asymmetric Total Synthesis of (−)-Sibirine; 2.3.3 MacMillan's Three-Step Asymmetric Total Synthesis of (+)-Frondosin B; 2.3.4 Hayashi's Three-Pot Total Synthesis of (−)-PGE1 Methyl Ester; 2.3.5 Porco's Three-Pot Total Synthesis of (−)-Hyperibone K; 2.4 Four-Step Enantioselective Total Synthesis of Natural Products; 2.4.1 Lawrence's Four-Step Total Synthesis of (−)-Angiopterlactone A
ISBN 9781118940211 (epub)
1118940210
9781118940204 (pdf)
9781118940228
1118940202
1118940229
9781118605400 (cloth)
1118605403
OCLC # 1037897235
Additional Format Print version: Efficiency in natural product total synthesis. First edition. Hoboken, NJ : John Wiley & Sons, 2018 9781118605400 (DLC) 2018008623


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