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Title Epigenetics in cardiac disease / Johannes Backs, Timothy A. McKinsey, editors.
Imprint Cham : Springer, [2016]

View online
View online
Series Cardiac and Vascular Biology.
Cardiac and vascular biology.
Subject Heart -- Diseases -- Genetic aspects.
Heart -- Diseases -- Pathogenesis.
Heart Diseases -- genetics.
Heart Diseases -- pathology.
Epigenesis, Genetic.
Alt Name Backs, Johannes,
McKinsey, Timothy A.,
Description 1 online resource (321 pages).
polychrome rdacc
Note Print version record.
Summary This book describes important advances in our understanding of how environmental conditions affect cardiac gene expression through epigenetic mechanisms. Further, it discusses the roles of chromatin modifications (in particular DNA methylation and histone modifications) and of chromatin regulators in the context of cardiac diseases. The book provides readers with an overview of our current understanding of epigenetic regulation in the heart, and will stimulate further research in this exciting field. Edited and written by internationally respected experts, it addresses the needs of professors, students and researchers working in the fields of cardiac biology and epigenetics.
Bibliography Note Includes bibliographical references at the end of each chapters.
Contents Preface; Contents; 1: Epigenetics: Chromatin Organization and Function; 1.1 Basic and Higher-Order Levels of Chromatin Structure; 1.2 Nucleosome Dynamics andGene Regulation; 1.3 Histone PTMs; 1.3.1 Histone Acetylation; 1.3.2 Histone Phosphorylation; 1.3.3 Histone Methylation; 1.3.4 Other PTMs of Histones; 1.4 DNA Methylation; 1.4.1 CpG Methylation; 1.4.2 CpH Methylation; 1.4.3 DNA Methylation-Related Regulatory Proteins; 1.5 Nucleosomes, Transcription and RNA Splicing; 1.6 Enhancers; 1.7 Epigenetics and Metabolism; 1.8 ncRNA and Epigenetic Modifiers; 1.9 Concluding Remarks.
2.3.2 Active Histone Marks: Acetyl-Lysine Readers; 2.3.3 Active and Inactive Histone Marks: Methyl-Lysine Readers; Recognition of H3K4me3; Recognition of H3K9me3; Phosphoserine Readers; References; 3: Epigenetic Regulations in Cardiac Development; 3.1 Heart Development; 3.1.1 Transcriptional Regulation of Cardiac Development; Nkx2-5; GATA; MEF2; Tbx; Hand; 3.2 Epigenetic Modifications; 3.2.1 DNA Methylation; 3.2.2 Histone Modifications; H3K4me3; H3K9me3; H3K27me3. ATP-Dependent Chromatin Remodeling; 3.3 Epigenetic Regulators in Cardiac Development and Disease; 3.3.1 H3K4 Methyltransferase; 3.3.2 H3K9 Methyltransferase; 3.3.3 H3K27 Demethylases; 3.3.4 ATP-Dependent Chromatin Remodeling Complexes; 3.4 Perspective; References; 4: DNA Methylation in Heart Failure; 4.1 Preface; 4.2 Mechanisms of DNA Methylation and Demethylation; 4.3 Regulation of DNA Methylation and Demethylation; 4.4 The DNA Methylation Landscape; 4.5 The Advent of DNA Methylation Research in Heart Disease; 4.6 The DNA Methylation Landscape in Healthy Heart.
4.7 DNA Methylation in Heart Failure; 4.7.1 Evidence from Studies in Humans; 4.7.2 Evidence from Animal Studies; 4.8 Therapeutic Considerations; 4.9 Biomarker Considerations; 4.10 Future Directions; References; 5: Chromatin Remodeling in Heart Failure; 5.1 Introduction; 5.2 ATP-Dependent Chromatin Remodeler and Cardiomyopathy: Lessons from Brg1; 5.2.1 Brg1 and Myocardial Morphogenesis; 5.2.2 Brg1 Function in Fetal and Adult Cardiomyocytes; 5.3 Other BAF Subunits and Heart Function; 5.4 Other ATP-Dependent Chromatin-Remodeling Factors and Heart Function.
ISBN 9783319414577 (electronic bk.)
3319414577 (electronic bk.)
ISBN/ISSN 10.1007/978-3-319-41457-7
OCLC # 964412425
Additional Format Print version: Epigenetics in Cardiac Disease. Cham : Springer International Publishing, 2016 9783319414553.