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024 7  10.1007/978-3-319-41457-7|2doi 
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245 00 Epigenetics in cardiac disease /|cJohannes Backs, Timothy 
       A. McKinsey, editors. 
264  1 Cham :|bSpringer,|c[2016] 
300    1 online resource (321 pages). 
336    text|btxt|2rdacontent 
337    computer|bc|2rdamedia 
338    online resource|bcr|2rdacarrier 
340    |gpolychrome|2rdacc|0http://rdaregistry.info/termList/
       RDAColourContent/1003 
347    text file|bPDF|2rda 
490 1  Cardiac and Vascular Biology. 
504    Includes bibliographical references at the end of each 
       chapters. 
505 0  Preface; Contents; 1: Epigenetics: Chromatin Organization 
       and Function; 1.1 Basic and Higher-Order Levels of 
       Chromatin Structure; 1.2 Nucleosome Dynamics andGene 
       Regulation; 1.3 Histone PTMs; 1.3.1 Histone Acetylation; 
       1.3.2 Histone Phosphorylation; 1.3.3 Histone Methylation; 
       1.3.4 Other PTMs of Histones; 1.4 DNA Methylation; 1.4.1 
       CpG Methylation; 1.4.2 CpH Methylation; 1.4.3 DNA 
       Methylation-Related Regulatory Proteins; 1.5 Nucleosomes, 
       Transcription and RNA Splicing; 1.6 Enhancers; 1.7 
       Epigenetics and Metabolism; 1.8 ncRNA and Epigenetic 
       Modifiers; 1.9 Concluding Remarks. 
505 8  2.3.2 Active Histone Marks: Acetyl-Lysine Readers; 2.3.3 
       Active and Inactive Histone Marks: Methyl-Lysine Readers; 
       2.3.3.1 Recognition of H3K4me3; 2.3.3.2 Recognition of 
       H3K9me3; 2.3.3.3 Phosphoserine Readers; References; 3: 
       Epigenetic Regulations in Cardiac Development; 3.1 Heart 
       Development; 3.1.1 Transcriptional Regulation of Cardiac 
       Development; 3.1.1.1 Nkx2-5; 3.1.1.2 GATA; 3.1.1.3 MEF2; 
       3.1.1.4 Tbx; 3.1.1.5 Hand; 3.2 Epigenetic Modifications; 
       3.2.1 DNA Methylation; 3.2.2 Histone Modifications; 
       3.2.2.1 H3K4me3; 3.2.2.2 H3K9me3; 3.2.2.3 H3K27me3. 
505 8  3.2.2.4 ATP-Dependent Chromatin Remodeling; 3.3 Epigenetic
       Regulators in Cardiac Development and Disease; 3.3.1 H3K4 
       Methyltransferase; 3.3.2 H3K9 Methyltransferase; 3.3.3 
       H3K27 Demethylases; 3.3.4 ATP-Dependent Chromatin 
       Remodeling Complexes; 3.4 Perspective; References; 4: DNA 
       Methylation in Heart Failure; 4.1 Preface; 4.2 Mechanisms 
       of DNA Methylation and Demethylation; 4.3 Regulation of 
       DNA Methylation and Demethylation; 4.4 The DNA Methylation
       Landscape; 4.5 The Advent of DNA Methylation Research in 
       Heart Disease; 4.6 The DNA Methylation Landscape in 
       Healthy Heart. 
505 8  4.7 DNA Methylation in Heart Failure; 4.7.1 Evidence from 
       Studies in Humans; 4.7.2 Evidence from Animal Studies; 4.8
       Therapeutic Considerations; 4.9 Biomarker Considerations; 
       4.10 Future Directions; References; 5: Chromatin 
       Remodeling in Heart Failure; 5.1 Introduction; 5.2 ATP-
       Dependent Chromatin Remodeler and Cardiomyopathy: Lessons 
       from Brg1; 5.2.1 Brg1 and Myocardial Morphogenesis; 5.2.2 
       Brg1 Function in Fetal and Adult Cardiomyocytes; 5.3 Other
       BAF Subunits and Heart Function; 5.4 Other ATP-Dependent 
       Chromatin-Remodeling Factors and Heart Function. 
520    This book describes important advances in our 
       understanding of how environmental conditions affect 
       cardiac gene expression through epigenetic mechanisms. 
       Further, it discusses the roles of chromatin modifications
       (in particular DNA methylation and histone modifications) 
       and of chromatin regulators in the context of cardiac 
       diseases. The book provides readers with an overview of 
       our current understanding of epigenetic regulation in the 
       heart, and will stimulate further research in this 
       exciting field. Edited and written by internationally 
       respected experts, it addresses the needs of professors, 
       students and researchers working in the fields of cardiac 
       biology and epigenetics. 
588 0  Print version record. 
650  0 Heart|xDiseases|xGenetic aspects.|0http://id.loc.gov/
       authorities/subjects/sh85059659 
650  0 Heart|xDiseases|xPathogenesis.|0http://id.loc.gov/
       authorities/subjects/sh88002812 
650  0 Epigenetics.|0http://id.loc.gov/authorities/subjects/
       sh2011005133 
650 12 Heart Diseases|xgenetics.|0https://id.nlm.nih.gov/mesh/
       D006331Q000235 
650 12 Heart Diseases|xpathology.|0https://id.nlm.nih.gov/mesh/
       D006331Q000473 
650 22 Epigenesis, Genetic.|0https://id.nlm.nih.gov/mesh/D044127 
655  4 Electronic books. 
700 1  Backs, Johannes,|0http://id.loc.gov/authorities/names/
       n2017183470|eeditor. 
700 1  McKinsey, Timothy A.,|0http://id.loc.gov/authorities/names
       /n2017183471|eeditor. 
776 08 |iPrint version:|tEpigenetics in Cardiac Disease.|dCham : 
       Springer International Publishing, 2016|z9783319414553. 
830  0 Cardiac and vascular biology.|0http://id.loc.gov/
       authorities/names/n2017183472 
990    SpringerLink|bSpringer English/International eBooks 2016 -
       Full Set|c2019-07-05|yMaster record variable field(s) 
       change: 505|5OH1 
990    SpringerLink|bSpringer English/International eBooks 2016 -
       Full Set|c2019-06-28|yMaster record 040 $e RDA change - 
       Master record variable field(s) change: 505|5OH1 
990    SpringerLink|bSpringer English/International eBooks 2016 -
       Full Set|c2018-11-30|yMaster record variable field(s) 
       change: 650|5OH1 
990    SpringerLink|bSpringer English/International eBooks 2016 -
       Full Set|c2018-11-23|yMaster record variable field(s) 
       change: 650|5OH1 
990    SpringerLink|bSpringer English/International eBooks 2016 -
       Full Set|c2018-10-31|yNew collection 
       springerlink.ebooks2016|5OH1 
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