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EBOOK
Title Fc mediated activity of antibodies : structural and functional diversity / Jeffrey V. Ravetch, Falk Nimmerjahn.
Imprint Cham : Springer, 2019.

LOCATION CALL # STATUS MESSAGE
 OHIOLINK SPRINGER EBOOKS    ONLINE  
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Series Current topics in microbiology and immunology, 2196-9965 ; v. 423.
Current topics in microbiology and immunology ; http://id.loc.gov/authorities/names/n42036058 423.
Subject Fc receptors.
Immunoglobulins.
Autoimmune diseases.
Alt Name Ravetch, J. V. (Jeffrey V.), 1951-
Nimmerjahn, Falk.
LOCATION CALL # STATUS MESSAGE
 OHIOLINK SPRINGER EBOOKS    ONLINE  
View online
Series Current topics in microbiology and immunology, 2196-9965 ; v. 423.
Current topics in microbiology and immunology ; http://id.loc.gov/authorities/names/n42036058 423.
Subject Fc receptors.
Immunoglobulins.
Autoimmune diseases.
Alt Name Ravetch, J. V. (Jeffrey V.), 1951-
Nimmerjahn, Falk.
Description 1 online resource (155 pages).
Bibliography Note Includes bibliographical references.
Note Online resource; title from PDF title page (SpringerLink, viewed September 20, 2019).
Contents IgG Fc receptors: evolutionary considerations -- Role of FcgRs in Antibody Based Cancer Therapy -- Anti-inflammatory Activity of IgG-Fc -- IgG Fc glycosylation in human immunity -- IgE Glycosylation in Health and Disease -- Immune Complex Vaccination -- Fc receptors in anti-microbial protection.
Summary This volume explores several aspects of how antibodies mediate their activity in vivo, ranging from cancer immunotherapy to autoimmunity, infection, and vaccination. Divided into seven chapters, it provides in-depth insights into how antibodies and especially the antibody fragment crystallizable (Fc) domain modulate immune responses and antibody activity. The book begins by discussing evolutionary aspects of how the family of Fc receptors that are the key molecules for antibody activity evolved. In turn, it addresses the molecular and cellular pathways underlying IgG activity in cancer immunotherapy, and focuses on how IgG glycosylation regulates IgG and IgE activity in autoimmunity, allergy and infection. In closing, it presents strategies for developing novel antibody-based vaccination approaches. The book is intended for a very broad readership, including graduate students, postdocs and principal investigators with a basic grasp of immunology.
ISBN 9783030310530 (electronic bk.)
3030310531 (electronic bk.)
ISBN/ISSN 10.1007/978-3-030-31
OCLC # 1119642459
Additional Format Print version: Ravetch, Jeffrey V. Fc Mediated Activity of Antibodies : Structural and Functional Diversity Cham : Springer,c2019 9783030310523.


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