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Title Inhalation delivery of therapeutic peptides and proteins / edited by Akwete Lex Adjei, Pramod K. Gupta.
Imprint New York : M. Dekker, 1997.

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Series Lung biology in health and disease ; v. 107
Lung biology in health and disease ; v. 107.
Subject Protein drugs -- Dosage forms.
Peptide drugs -- Dosage forms.
Aerosol therapy.
Administration, Inhalation.
Drug Delivery Systems.
Aerosols.
Peptides -- therapeutic use.
Proteins -- therapeutic use.
Alt Name Adjei, Akwete Lex, 1949-
Gupta, Pramod K., 1959-
Description 1 online resource (xxxii, 913 pages) : illustrations.
Bibliography Note Includes bibliographical references and indexes.
Note Print version record.
ISBN 0585158673 (electronic bk.)
9780585158679 (electronic bk.)
0824797809 (hardcover ; alk. paper)
OCLC # 44959924
Additional Format Print version: Inhalation delivery of therapeutic peptides and proteins. New York : M. Dekker, 1997 0824797809 (DLC) 97015722 (OCoLC)37030499
Table of Contents
 Introduction / Claude Lenfant 
 Foreword / Peter R. Byron 
 Foreword / David Ganderton 
 Foreword / Stephen P. Newman 
 Preface 
 Acknowledgments 
 Contributors 
Pt. 1The Human Respiratory Tract: Biophysical Issues in Peptide Drug Delivery / Pramod K. Gupta1
 1Physiological and Biomechanical Factors Relevant to Inhaled Drug Delivery / Chong S. Kim, Lawrence J. Folinsbee3
 2Biophysics of Inhaled Drug Particles / Ananth Annapragada, Paul Swanson, Fernando Muzzio27
 3Chemical and Physical Properties of Peptide and Protein Drugs / William R. Porter59
 4Absorption and Bioavailability of Inhaled Peptides and Proteins / Yihong Qiu, Pramod K. Gupta, Akwete Lex Adjei89
Pt. 2The Human Respiratory Tract: Pharmaceutical Issues in Peptide Drug Delivery / Akwete Lex Adjei133
 5Intranasal Delivery of Peptides and Proteins / Lisbeth Illum, Anthony Neil Fisher135
 6Therapeutic Inhalation Aerosols / Pramod K. Gupta, Akwete Lex Adjei185
 7Generation and Characterization of Aerosols for Drug Delivery to the Lungs / Cecily B. Lalor, Anthony J. Hickey235
Pt. 3Localized Delivery of Peptides and Proteins to the Lung: Case Studies / Akwete Lex Adjei277
 8Cyclosporine / Gilbert J. Burckart, Robert Keenam, Bartley P. Griffith [et al.]281
 9Inhalation Interferon / Nico van Zandwijk301
 10Alpha-1 Antitrypsin / Richard C. Hubbard315
 11Aerosol Delivery of Alpha, Proteinase Inhabitor: A Paradigm for Delivery of Therapeutic Proteins to the Lung / Robert M. Smith331
 12Deoxyribonuclease Inhalation / Igor Gonda355
Pt. 4Systemic Delivery of Peptides and Proteins by Inhalation: Case Studies / Akwete Lex Adjei, Pramod K. Gupta367
 13Insulin Inhalation: Its Potential as a Nonparenteral Method of Administration / Stephen J. Farr, Glyn Taylor371
 14LH-RH Analogs / Akwete Lex Adjei, Mou-ying Fu Lu389
 15Feasibility Studies with Recombinant Human Granulocyte Colony-Stimulating Factor / Ralph W. Niven413
 16Inhalation Therapy for Growth Hormone Deficiency / Doris A. Wall, Philip L. Smith453
Pt. 5Gene Delivery and Transfer via the Lung / Akwete Lex Adjei471
 17General Issues in Gene Delivery via the Lung / Marsha M. Thompson, Jeanine P. Wiener-Kronish475
 18Inhalation Delivery and Formulation Issues in Gene Therapy in the Respiratory Tract / Thomas W. Patapoff, Igor Gonda493
 19Gene Therapy for Lung Disease: Molecular and Clinical Therapeutic Issues / Larry G. Johnson, Richard C. Boucher515
 20The Cell Biology of Gene Therapy for Cystic Fibrosis / Kenneth Crook, David J. Porteous555
Pt. 6Alternate Technologies in Pulmonary Delivery / Akwete Lex Adjei, Pramod K. Gupta587
 21Non-Ozone-Depleting Propellants / Pramod K. Gupta, Akwete Lex Adjei591
 22Dry-Powder Inhalation Aerosols / Akwete Lex Adjei, Pramod K. Gupta625
 23Modulated-Release Aerosol / Pramod K. Gupta, Akwete Lex Adjei667
 24Novel Aerosol Peptide Drug Delivery Systems / Reid Rubsamen703
Pt. 7Guidelines for Development of Aerosolized Peptides / Akwete Lex Adjei733
 25Developmental Pharmaceutics of Inhaled Peptides and Proteins / Akwete Lex Adjei, Pramod K. Gupta735
 26Clinical Development of Inhaled Peptides and Proteins / Akwete Lex Adjei771
Pt. 8Key Worldwide Patents in Pulmonary Drug Delivery / Pramod K. Gupta815
 27Key Worldwide Patents in Pulmonary Drug Delivery / Pramod K. Gupta, Akwete Lex Adjei817
 Author Index861
 Subject Index903


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